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AB120317

NNC 05-2090, GABA uptake inhibitor

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MW 451 Da, Purity >99%. GABA uptake inhibitor, selective for the BGT-1 transporter (Ki values are 1.4 (BGT-1), 19 (GAT-1), 41 (GAT-2) and 15 μM (GAT-3)). Also active at α1- and D2-receptors (IC50 values are 266 and 1632 nM, respectively). Anticonvulsant in vivo.
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Chemical Structure - NNC 05-2090, GABA uptake inhibitor (AB120317)
  • Chemical Structure

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Chemical Structure - NNC 05-2090, GABA uptake inhibitor (AB120317)

2D chemical structure image of ab120317, NNC 05-2090, GABA uptake inhibitor

Key facts

CAS number

184845-43-0

Purity

>99%

Form

Solid

form

Molecular weight

451 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>3</sub><sub>1</sub>ClN<sub>2</sub>O<sub>2</sub>

PubChem

18782760

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

1-[3-(9H-Carbazol-9-YL)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride

Biological description

GABA uptake inhibitor, selective for the BGT-1 transporter (Ki values are 1.4 (BGT-1), 19 (GAT-1), 41 (GAT-2) and 15 μM (GAT-3)). Also active at α1- and D2-receptors (IC50 values are 266 and 1632 nM, respectively). Anticonvulsant in vivo.

Canonical smiles

COC1=CC=CC=C1C2(CCN(CC2)CCCN3C4=CC=CC=C4C5=CC=CC=C53)O.Cl

InChi

InChI=1S/C27H30N2O2.ClH/c1-31-26-14-7-4-11-23(26)27(30)15-19-28(20-16-27)17-8-18-29-24-12-5-2-9-21(24)22-10-3-6-13-25(22)29;/h2-7,9-14,30H,8,15-20H2,1H3;1H

InChiKey

WDFXPKKFSNMGOO-UHFFFAOYSA-N

IUPAC Name

1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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