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MW 451 Da, Purity >99%. GABA uptake inhibitor, selective for the BGT-1 transporter (Ki values are 1.4 (BGT-1), 19 (GAT-1), 41 (GAT-2) and 15 μM (GAT-3)). Also active at α1- and D2-receptors (IC50 values are 266 and 1632 nM, respectively). Anticonvulsant in vivo.

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Images

Chemical Structure - NNC 05-2090, GABA uptake inhibitor (AB120317), expandable thumbnail

Key facts

CAS number
184845-43-0
Purity
> 99%
Form
Solid
Molecular weight
451 Da
Molecular formula
C27H31ClN2O2
PubChem identifier
18782760
Nature
Synthetic

Target data

Recommended products

MW 451 Da, Purity >99%. GABA uptake inhibitor, selective for the BGT-1 transporter (Ki values are 1.4 (BGT-1), 19 (GAT-1), 41 (GAT-2) and 15 μM (GAT-3)). Also active at α1- and D2-receptors (IC50 values are 266 and 1632 nM, respectively). Anticonvulsant in vivo.

Key facts

Purity
> 99%
PubChem identifier
18782760
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
1-[3-(9H-Carbazol-9-YL)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
Biological description

GABA uptake inhibitor, selective for the BGT-1 transporter (Ki values are 1.4 (BGT-1), 19 (GAT-1), 41 (GAT-2) and 15 μM (GAT-3)). Also active at α1- and D2-receptors (IC50 values are 266 and 1632 nM, respectively). Anticonvulsant in vivo.

Canonical SMILES
COC1=CC=CC=C1C2(CCN(CC2)CCCN3C4=CC=CC=C4C5=CC=CC=C53)O.Cl
InChI
InChI=1S/C27H30N2O2.ClH/c1-31-26-14-7-4-11-23(26)27(30)15-19-28(20-16-27)17-8-18-29-24-12-5-2-9-21(24)22-10-3-6-13-25(22)29;/h2-7,9-14,30H,8,15-20H2,1H3;1H
InChIKey
WDFXPKKFSNMGOO-UHFFFAOYSA-N
IUPAC name
1-(3-carbazol-9-ylpropyl)-4-(2-methoxyphenyl)piperidin-4-ol;hydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - NNC 05-2090, GABA uptake inhibitor (ab120317), expandable thumbnail

    Chemical Structure - NNC 05-2090, GABA uptake inhibitor (ab120317)

    2D chemical structure image of ab120317, NNC 05-2090, GABA uptake inhibitor

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Product protocols

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