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MW 386.9 Da, Purity >99%. Potent and selective GAT-1 GABA uptake inhibitor. (IC50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro. Potent anticonvulsant, neuroprotectant and cognitive enhancer in vivo.

Also available in simple stock solutions (ab146719) - add 1 ml of water to get an exact, ready-to-use concentration.

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Key facts

CAS number

145645-62-1

Purity

> 99%

Form

Solid

Molecular weight

386.9 Da

Molecular formula

C21H23ClN2O3

PubChem identifier

123738

Nature

Synthetic

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Alternative names

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MW 386.9 Da, Purity >99%. Potent and selective GAT-1 GABA uptake inhibitor. (IC50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro. Potent anticonvulsant, neuroprotectant and cognitive enhancer in vivo.

Also available in simple stock solutions (ab146719) - add 1 ml of water to get an exact, ready-to-use concentration.

Alternative names

Key facts

Purity

> 99%

PubChem identifier

123738

Biochemical name

1-(2-(((Diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid

Biological description

Potent and selective GAT-1 GABA uptake inhibitor. (IC50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro. Potent anticonvulsant, neuroprotectant and cognitive enhancer in vivo.

Also available in simple stock solutions (ab146719) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical SMILES

C1CN(CC(=C1)C(=O)O)CCON=C(C2=CC=CC=C2)C3=CC=CC=C3.Cl

InChI

InChI=1S/C21H22N2O3.ClH/c24-21(25)19-12-7-13-23(16-19)14-15-26-22-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18;/h1-6,8-12H,7,13-16H2,(H,24,25);1H

InChIKey

YZYRTEYMUTWJPL-UHFFFAOYSA-N

IUPAC name

1-[2-(benzhydrylideneamino)oxyethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid;hydrochloride

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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1 product image

  • Chemical Structure - NNC 711, GAT-1 inhibitor (ab120364), expandable thumbnail

    Chemical Structure - NNC 711, GAT-1 inhibitor (ab120364)

    2D chemical structure image of ab120364, NNC 711, GAT-1 inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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