MW 386.9 Da, Purity >99%. Potent and selective GAT-1 GABA uptake inhibitor. (IC50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro. Potent anticonvulsant, neuroprotectant and cognitive enhancer in vivo.
Also available in simple stock solutions (ab146719) - add 1 ml of water to get an exact, ready-to-use concentration.
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- Journal of neurophysiology 113:3421-312015Neurosteroids increase tonic GABAergic inhibition in the lateral section of the central amygdala in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesH Romo-Parra et. al.PubMed 25787948
Key facts
- CAS number
- 145645-62-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 386.9 Da
- Molecular formula
- C21H23ClN2O3
- PubChem identifier
- 123738
- Nature
- Synthetic
Target data
Alternative names
GABATHG, GABATR, GABT 1, GAT-1, SC6A1_HUMAN, Slc6a1, Sodium- and chloride-dependent GABA transporter 1, Solute carrier family 6 (neurotransmitter transporter GABA) member 1, Solute carrier family 6 member 1
Recommended products
MW 386.9 Da, Purity >99%. Potent and selective GAT-1 GABA uptake inhibitor. (IC50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro. Potent anticonvulsant, neuroprotectant and cognitive enhancer in vivo.
Also available in simple stock solutions (ab146719) - add 1 ml of water to get an exact, ready-to-use concentration.
Key facts
- CAS number
- 145645-62-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 386.9 Da
- Molecular formula
- C21H23ClN2O3
- PubChem identifier
- 123738
- Nature
- Synthetic
- Solubility
Soluble in water to 10 mM.
- Biochemical name
- 1-(2-(((Diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid
- Biological description
Potent and selective GAT-1 GABA uptake inhibitor. (IC50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro. Potent anticonvulsant, neuroprotectant and cognitive enhancer in vivo.
Also available in simple stock solutions (ab146719) - add 1 ml of water to get an exact, ready-to-use concentration.- Canonical SMILES
- C1CN(CC(=C1)C(=O)O)CCON=C(C2=CC=CC=C2)C3=CC=CC=C3.Cl
- InChI
- InChI=1S/C21H22N2O3.ClH/c24-21(25)19-12-7-13-23(16-19)14-15-26-22-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18;/h1-6,8-12H,7,13-16H2,(H,24,25);1H
- InChIKey
- YZYRTEYMUTWJPL-UHFFFAOYSA-N
- IUPAC name
- 1-[2-(benzhydrylideneamino)oxyethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - NNC 711, GAT-1 inhibitor (ab120364)
2D chemical structure image of ab120364, NNC 711, GAT-1 inhibitor
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