NNGH, Matrix metalloprotease (MMP) inhibitor
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(1 Publication)
MW 316.38 Da, Purity >98%. MMP3 (Stromelysin-1) inhibitor. Additionally shows broad spectrum inhibition activity at other MMPs. Cell permeable.
View Alternative Names
27 kDa interstitial collagenase, 72 kDa gelatinase, 72kD type IV collagenase, 82 kDa matrix metalloproteinase-9, 92 kDa gelatinase, 92 kDa type IV collagenase, A disintegrin and metalloproteinase domain 17, A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), ADA17_HUMAN, ADAM 17, ADAM metallopeptidase domain 17, ADAM17 protein, CD 156b, CD156b antigen, CHDS6, CLG, CLG 1, CLG 3, CLG 4, CLG 4A, CLG 4B, CSVP, Collagenase 1, Collagenase 1 neutrophil, Collagenase 3, Collagenase Type 4 alpha, Collagenase Type 4 beta, Collagenase type IV 92 KD, Collagenase type IV A, Disintegrin and metalloproteinase domain-containing protein 17, EC 3.4.24.35, EC 3.4.24.65, Fibroblast collagenase, GELB, Gelatinase 92 KD, Gelatinase A, Gelatinase B, Gelatinase alpha, Gelatinase beta, Gelatinase neutrophil, HME, HNC, Interstitial collagenase, MANDP1, MANDP2, ME, MGC126102, MGC126103, MGC126104, MGC138506, MGC71942, MME, MMP II, MMP-X1, MMP12_HUMAN, MMP13_HUMAN, MMP14_HUMAN, MMP1_HUMAN, MMP2_HUMAN, MMP3_HUMAN, MMP7_HUMAN, MMP8_HUMAN, MMP9_HUMAN, MONA, MPSL1, MT-MMP 1, MT1-MMP, Macrophage elastase, Macrophage gelatinase, Macrophage metalloelastase, Macrophage metaloelastase, Matrilysin, Matrin, Matrix Metalloproteinase 9, Matrix metallopeptidase 1 (interstitial collagenase), Matrix metallopeptidase 12 (macrophage elastase), Matrix metallopeptidase 13 (collagenase 3), Matrix metallopeptidase 14 (membrane inserted), Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase, Matrix metallopeptidase 8 (neutrophil collagenase), Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), Matrix metalloprotease 1, Matrix metalloprotease 12, Matrix metalloprotease 8, Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), Matrix metalloproteinase 3 preproprotein, Matrix metalloproteinase II, Matrix metalloproteinase-1, Matrix metalloproteinase-12, Matrix metalloproteinase-13, Matrix metalloproteinase-14, Matrix metalloproteinase-2, Matrix metalloproteinase-3, Matrix metalloproteinase-7, Matrix metalloproteinase-8, Membrane type 1 metalloprotease, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase, NISBD, NISBD1, Neutrophil collagenase, Neutrophil gelatinase, OTTHUMP00000045866, PEX, PMNL collagenase, PMNL-CL, PUMP 1, Proteoglycanase, Pump-1 protease, SL-1, STMY, STMY1, Snake venom-like protease, Stromelisin 1, Stromelysin 1 progelatinase, Stromelysin-1, TACE, TBE-1, TNF-alpha convertase, TNF-alpha-converting enzyme, Transin-1, Tumor Necrosis Factor Alpha Converting Enzyme, Type V collagenase, Uterine matrilysin, Uterine metalloproteinase, collagenase, fibroblast, collagenase, interstitial
- Chemical Structure
Lab
Chemical Structure - NNGH, Matrix metalloprotease (MMP) inhibitor (AB141259)
2D chemical structure image of ab141259, NNGH, Matrix metalloprotease (MMP) inhibitor
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Matrix metalloproteases play a role in tissue remodeling wound healing and the inflammatory response. These enzymes collaborate in complexes that manage extracellular matrix degradation ensuring proper tissue repair and remodeling. MMP7 also called matrilysin has a role in processing bioactive molecules. ADAM17 known as TACE (Tumor Necrosis Factor-Alpha-Converting Enzyme) regulates the shedding of cell surface proteins that affect cell signaling and communication. Inhibiting specific MMPs helps control excessive matrix degradation representing an important function in maintaining cellular environments.
Pathways
The functions of matrix metalloproteases extend into processes like the cytokine signaling pathway and the cell-matrix adhesion pathway. MMP9 and other MMPs facilitate the release of cytokines growth factors and cell surface receptors which are central to immune responses and cell migration. Links between these proteases and proteins such as tissue inhibitors of metalloproteinases (TIMPs) balance matrix degradation and synthesis. This regulation is critical for maintaining homeostasis and proper tissue architecture.
Publications (1)
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Translational oncology 14:101221 PubMed34530193
2021
Applications
Unspecified application
Species
Unspecified reactive species
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