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AB142927

Nobiletin, Matrix metalloprotease (MMP) inhibitor

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MW 402.4 Da, Purity >97%. Polymethoxylated flavone. Potent MMP inhibitor. Inhibits proMMP-1, 3, and 9 production. Shows anti-inflammatory and antitumor effects in vivo. Orally active.

View Alternative Names

2700049B16Rik, 3110031N04Rik, BK channel, BK channel beta subunit, BK channel subunit beta-1, BK channel subunit beta-2, BK channel subunit beta-4, BKCA alpha, BKCA alpha subunit, BKTM, BKbeta, BKbeta1, BKbeta2, BKbeta4, CAPC, Calcium activated potassium channel beta 4 subunit, Calcium activated potassium channel subfamily M subunit beta 1, Calcium activated potassium channel subfamily M subunit beta 2, Calcium activated potassium channel subfamily M subunit beta 4, Calcium-activated potassium channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel subunit beta, Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel subunit beta-2, Calcium-activated potassium channel subunit beta-4, Charybdotoxin receptor subunit beta-1, Charybdotoxin receptor subunit beta-2, Charybdotoxin receptor subunit beta-4, Cytokeratin-associated protein in cancer, Drosophila slowpoke like, Hbeta1, Hbeta2, Hbeta3, Hbeta4, K(VCA)alpha, K(VCA)beta, K(VCA)beta-1, K(VCA)beta-2, K(VCA)beta-4, KCMA1_HUMAN, KCMB1_HUMAN, KCMB2_HUMAN, KCMB4_HUMAN, KCNMA, KCNMA1, KCNMB 1, KCNMB 2, KCa1.1, LRC26_HUMAN, Large conductance Ca2+ activated K+ channel beta 1 subunit, Large conductance Ca2+ activated K+ channel beta2 subunit, Large conductance calcium activated potassium channel beta 2 subunit, Large conductance calcium dependent potassium ion channel beta 4 subunit, Leucine-rich repeat-containing protein 26, Lrrc26, MGC22431, MGC57945, Maxi K channel, Maxi K channel beta subunit, Maxi K channel subunit beta-1, Maxi K channel subunit beta-2, Maxi K channel subunit beta-4, Maxi Potassium channel alpha, MaxiK, MaxiK channel beta 2 subunit, Potassium large conductance calcium activated channel subfamily M beta member 1, Potassium large conductance calcium activated channel subfamily M beta member 2, Potassium large conductance calcium activated channel subfamily M beta member 4, SAKCA, SLO, Slo homolog, Slo-alpha, Slo-beta, Slo-beta-1, Slo-beta-2, Slo-beta-4, Slo1, Slowpoke homolog, bA350O14.10, cytokeratin-associated protein, hSlo, hslo beta, subfamily M subunit alpha-1, subfamily M subunit beta-1, subfamily M subunit beta-2, subfamily M subunit beta-4

1 Images
Chemical Structure - Nobiletin, Matrix metalloprotease (MMP) inhibitor (AB142927)
  • Chemical Structure

Lab

Chemical Structure - Nobiletin, Matrix metalloprotease (MMP) inhibitor (AB142927)

2D chemical structure image of ab142927, Nobiletin, Matrix metalloprotease (MMP) inhibitor

Key facts

CAS number

478-01-3

Purity

>97%

Molecular weight

402.4 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>2</sub>O<sub>8</sub>

PubChem

72344

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Nobiletin

Biological description

Polymethoxylated flavone. Potent MMP inhibitor. Inhibits proMMP-1, 3, and 9 production. Shows anti-inflammatory and antitumor effects in vivo. Orally active.

Canonical smiles

COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC

InChi

InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3

InChiKey

MRIAQLRQZPPODS-UHFFFAOYSA-N

IUPAC Name

2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product protocols

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