MW 219.2 Da, Purity >99%. Nitric oxide synthase inhibitor (Ki = 4.4 μM). Cardiovascular effects. Active in vivo.
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- Antioxidants (Basel, Switzerland) 12:2023Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesModar Kassan,Youngin Kwon,Undral Munkhsaikhan,Amal M Sahyoun,Tauheed Ishrat,María Galán,Alexis A Gonzalez,Ammaar H Abidi,Adam Kassan,Karima Ait-AissaPubMed 36671022
- Journal of pregnancy 2019:43023092019Changes in Gastric Smooth Muscle Cell Contraction during Pregnancy: Effect of Estrogen.Applications:Unspecified applicationReactive species:Unspecified reactive speciesOthman A Al-Shboul et. al.PubMed 31080672
- Biomedical reports 9:511-5162018Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesOthman A Al-Shboul et. al.PubMed 30546879
- Experimental and therapeutic medicine 16:1685-16922018Estrogen relaxes gastric muscle cells via a nitric oxide- and cyclic guanosine monophosphate-dependent mechanism: A sex-associated differential effect.Applications:Unspecified applicationReactive species:Unspecified reactive speciesOthman A Al-Shboul et. al.PubMed 30186388
Key facts
- CAS number
- 2149-70-4
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 219.2 Da
- Molecular formula
- C6H13N5O4
- PubChem identifier
- 440005
- Nature
- Synthetic
Target data
Alternative names
BNOS, Constitutive NOS, EC-NOS, EP2, Endothelial NOS, Endothelial nitric oxidase synthase, Endothelial nitric oxide synthase, Endothelial nitric oxide synthase 3, HEP-NOS, Hepatocyte NOS, IHPS 1, Inducible NO synthase, Inducible NOS, Inducible nitric oxide synthase, MAC NOS, Macrophage NOS, N-NOS, NC-NOS, NOS, NOS III, NOS type I, NOS type II, NOS type III, NOS2A, NOS2A, Inducible, Hepatocyte, NOS2_HUMAN, NOS3_HUMAN, Neuronal NOS, Nitric oxide synthase, Nitric oxide synthase 1, Nitric oxide synthase 1 neuronal, Nitric oxide synthase 2 inducible, Nitric oxide synthase 2 inducible macrophage, Nitric oxide synthase 3, Nitric oxide synthase 3 (endothelial cell), Nitric oxide synthase 3 endothelial cell, Nitric oxide synthase brain, Nitric oxide synthase endothelial, Nitric oxide synthase inducible, Nos II, PE2R2_HUMAN, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, PTGER 2, Peptidyl-cysteine S-nitrosylase NOS2, Prostaglandin E receptor 2 EP2 subtype, Prostaglandin E receptor 2 subtype EP2, Prostaglandin E receptor 2 subtype EP2 53kDa, Prostaglandin E2 receptor, Prostaglandin E2 receptor EP2 subtype, Prostanoid EP2 receptor, cNOS, eNOS, iNOS, inducible, neuronal Nitric Oxide Synthase, nitric oxide synthase 2A (inducible, hepatocytes), nitric oxide synthase, macrophage
Recommended products
MW 219.2 Da, Purity >99%. Nitric oxide synthase inhibitor (Ki = 4.4 μM). Cardiovascular effects. Active in vivo.
Key facts
- CAS number
- 2149-70-4
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 219.2 Da
- Molecular formula
- C6H13N5O4
- PubChem identifier
- 440005
- Nature
- Synthetic
- Solubility
Soluble in water to 5 mM.
- Biochemical name
- Nitroarginine
- Biological description
Nitric oxide synthase inhibitor (Ki = 4.4 μM). Cardiovascular effects. Active in vivo.
- Canonical SMILES
- C(CC(C(=O)O)N)CN=C(N)N[N+](=O)[O-]
- Isomeric SMILES
- C(C[C@@H](C(=O)O)N)CN=C(N)N[N+](=O)[O-]
- InChI
- InChI=1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1
- InChIKey
- MRAUNPAHJZDYCK-BYPYZUCNSA-N
- IUPAC name
- (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoic acid
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Endothelial nitric oxide synthase (eNOS) inducible nitric oxide synthase (iNOS) and the Prostaglandin E Receptor EP2 (PTGER2) represent a diverse group of proteins with significant roles in various physiological processes. eNOS also known under the names NOS3 is primarily localized in endothelial cells and weighs approximately 133 kDa. It catalyzes the production of nitric oxide (NO) from L-arginine. Meanwhile iNOS is expressed in macrophages and some vascular cells and plays a role in immune responses. PTGER2 on the other hand is a receptor for prostaglandin E2 expressed in numerous tissues including the brain and kidneys. Each entity has a distinct function but shares interrelated pathways.
- Biological function summary
These proteins and receptors influence various cellular functions and behavior. eNOS produces NO which acts as a signaling molecule facilitating vasodilation and influencing vascular tone. iNOS becomes activated during inflammatory responses and contributes to immune defense by producing NO. PTGER2 a G-protein-coupled receptor mediates the actions of prostaglandin E2 influencing processes like inflammation and vasodilation. While these proteins and receptors do not form a single complex they function collaboratively or independently within the cellular environment.
- Pathways
The roles played by eNOS iNOS and PTGER2 integrate into broader biological networks. eNOS and iNOS are integral parts of the nitric oxide signaling pathway where NO interacts with guanylate cyclase to influence vascular smooth muscle relaxation. PTGER2 connects to the prostaglandin signaling pathway regulating complex physiological responses. These pathways often intersect sharing links with proteins such as cyclooxygenase-2 (COX-2) and guanylate cyclase important in modulating inflammation and vascular homeostasis.
- Associated diseases and disorders
The functions of eNOS iNOS and PTGER2 contribute to various pathological conditions. Dysfunction of eNOS often related to reduced NO availability associates with cardiovascular disorders including hypertension and atherosclerosis. Dysregulation of iNOS expression links to chronic inflammatory states such as rheumatoid arthritis. PTGER2's role in inflammation and vascular regulation connects it to disorders including inflammatory bowel disease interacting with proteins like COX-2 potentiating chronic inflammation. These interactions highlight both potential therapeutic targets and areas for further research.
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Chemical Structure - Nomega-Nitro-L-arginine (L-NNA), Nitric oxide synthase inhibitor (ab141312)
2D chemical structure image of ab141312, Nomega-Nitro-L-arginine (L-NNA), Nitric oxide synthase inhibitor
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