Nomega-Nitro-L-arginine (L-NNA), Nitric oxide synthase inhibitor
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(4 Publications)
MW 219.2 Da, Purity >99%. Nitric oxide synthase inhibitor (Ki = 4.4 μM). Cardiovascular effects. Active in vivo.
View Alternative Names
BNOS, Constitutive NOS, EC-NOS, EP2, Endothelial NOS, Endothelial nitric oxidase synthase, Endothelial nitric oxide synthase, Endothelial nitric oxide synthase 3, HEP-NOS, Hepatocyte NOS, IHPS 1, Inducible NO synthase, Inducible NOS, Inducible nitric oxide synthase, MAC NOS, Macrophage NOS, N-NOS, NC-NOS, NOS, NOS III, NOS type I, NOS type II, NOS type III, NOS2A, NOS2A, Inducible, Hepatocyte, NOS2_HUMAN, NOS3_HUMAN, Neuronal NOS, Nitric oxide synthase, Nitric oxide synthase 1, Nitric oxide synthase 1 neuronal, Nitric oxide synthase 2 inducible, Nitric oxide synthase 2 inducible macrophage, Nitric oxide synthase 3, Nitric oxide synthase 3 (endothelial cell), Nitric oxide synthase 3 endothelial cell, Nitric oxide synthase brain, Nitric oxide synthase endothelial, Nitric oxide synthase inducible, Nos II, PE2R2_HUMAN, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, PTGER 2, Peptidyl-cysteine S-nitrosylase NOS2, Prostaglandin E receptor 2 EP2 subtype, Prostaglandin E receptor 2 subtype EP2, Prostaglandin E receptor 2 subtype EP2 53kDa, Prostaglandin E2 receptor, Prostaglandin E2 receptor EP2 subtype, Prostanoid EP2 receptor, cNOS, eNOS, iNOS, inducible, neuronal Nitric Oxide Synthase, nitric oxide synthase 2A (inducible, hepatocytes), nitric oxide synthase, macrophage
- Chemical Structure
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Chemical Structure - Nomega-Nitro-L-arginine (L-NNA), Nitric oxide synthase inhibitor (AB141312)
2D chemical structure image of ab141312, Nomega-Nitro-L-arginine (L-NNA), Nitric oxide synthase inhibitor
Properties and storage information
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These proteins and receptors influence various cellular functions and behavior. eNOS produces NO which acts as a signaling molecule facilitating vasodilation and influencing vascular tone. iNOS becomes activated during inflammatory responses and contributes to immune defense by producing NO. PTGER2 a G-protein-coupled receptor mediates the actions of prostaglandin E2 influencing processes like inflammation and vasodilation. While these proteins and receptors do not form a single complex they function collaboratively or independently within the cellular environment.
Pathways
The roles played by eNOS iNOS and PTGER2 integrate into broader biological networks. eNOS and iNOS are integral parts of the nitric oxide signaling pathway where NO interacts with guanylate cyclase to influence vascular smooth muscle relaxation. PTGER2 connects to the prostaglandin signaling pathway regulating complex physiological responses. These pathways often intersect sharing links with proteins such as cyclooxygenase-2 (COX-2) and guanylate cyclase important in modulating inflammation and vascular homeostasis.
Publications (4)
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Antioxidants (Basel, Switzerland) 12: PubMed36671022
2023
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Journal of pregnancy 2019:4302309 PubMed31080672
2019
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Biomedical reports 9:511-516 PubMed30546879
2018
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Experimental and therapeutic medicine 16:1685-1692 PubMed30186388
2018
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