MW 293.4 Da, Purity >98%. TRPV1 agonist. Less potent Capsaicin (ab141000) analog. Induces Ca2+ release from ER. Blood-brain barrier permeable. Active in vivo.
View Alternative Names
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, 1,8-cineole 2-exo-monooxygenase, 15 LIPOXYGENASE RETICULOCYTE ARACHIDONATE, 15 LOX 1, 15 lipoxygenase 1, 15-LOX, ACLS, AIS, ALOX15, ANDR_HUMAN, AR, AR8, Albendazole monooxygenase, Albendazole sulfoxidase, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Arachidonate 15-lipoxygenase, Arachidonate omega-6 lipoxygenase, BCYM3, BXR, CMT2C, CP2C9_HUMAN, CP33, CP34, CP3A4_HUMAN, CPC9, CYP2C, CYP2C10, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIC9, CYPIIIA3, CYPIIIA4, Capsaicin receptor, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 NF-25, Cytochrome P450 PB-1, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-PCN1, DHTR, DKFZp434K0220, DNA binding protein, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), GCCR, GCPS, GCRST, GCR_HUMAN, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, GR, Glioma associated oncogene family zinc finger 3, Glucocorticoid inducible P450, Glucocorticoid receptor, Grl1, HLP, HMSN2C, HUMARA, HYSP1, KD, Kennedy disease (KD), LOG15, LOX15_HUMAN, MGC12549, MGC126680, MGC149605, MGC88320, Microsomal monooxygenase, NF 25, NR1I2_HUMAN, NR3C3, NR3C4, Nifedipine oxidase, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 3, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), ONR 1, OSM9 like transient receptor potential channel 4, OTRPC 4, OTRPC1, OTRPC2, OTTHUMP00000020135, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene GLI3, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, Osm-9-like TRP channel 1, Osm-9-like TRP channel 2, Osm-9-like TRP channel 4, Osmosensitive transient receptor potential channel 4, P450 III steroid inducible, P450 MP, P450 PB 1, P450 PCN1, P450, family III, P450C3, P450IIC9, PAP A, PAPB, PAR, PAR q, PGR, PPD IV, PR, PRA, PRB, PRGR_HUMAN, PRR, Pregnane X receptor, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, Quinine 3-monooxygenase, S-mephenytoin 4-hydroxylase, SBMA, SMAL, SMAX1, SPSMA, SSQTL1, SXR, Sac2b, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid and xenobiotic receptor, Stretch activated channel 2B, TFM, TRP 12, TRPV1_HUMAN, TRPV2_HUMAN, TRPV4_HUMAN, Taurochenodeoxycholate 6-alpha-hydroxylase, Testicular Feminization (TFM), Transcriptional activator GLI3, Transcriptional repressor GLI3R, Transient receptor potential cation channel subfamily V member 1, Transient receptor potential cation channel subfamily V member 2, Transient receptor potential cation channel subfamily V member 4, Transient receptor potential protein 12, VR 1, VR 4, VR-OAC, VRL, VRL-1, VRL-2, Vanilloid receptor 1, Vanilloid receptor subtype 1, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 1, Vanilloid receptor-like protein 2, Vanilloid receptor-related osmotically-activated channel, Xenobiotic monooxygenase, Zinc finger protein GLI 3, androgen receptor splice variant 4b, cytochrome P-450 S-mephenytoin 4-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, flavoprotein-linked monooxygenase, glucocorticoid nuclear receptor variant 1, nr3c1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), pregnane X nuclear receptor variant 2
- Chemical Structure
Lab
Chemical Structure - Nonivamide, TRPV1 agonist (AB144652)
2D chemical structure image of ab144652, Nonivamide, TRPV1 agonist
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Expression and interaction of these proteins participate in various cellular mechanisms. TRPV1 detects heat and pH changes integrating pain and heat sensations while TRPV2 responds to mechanical stimuli possibly interacting in immune cells. The Glucocorticoid Receptor mediates stress responses by regulating gene expression usually forming a receptor-ligand complex. Progesterone and Androgen receptors regulate reproductive system development and function through gene regulation. Gli3 acts in developing tissue particularly influencing organismal growth via transcriptional regulation. Cytochromes CYP3A4 and CYP2C9 metabolize pharmaceuticals and are part of a group of enzymes that facilitate detoxification processes. The PXR receptor supports the transcription of metabolizing genes. It often complexes with CYP3A4 affecting drug clearance rates. TRPV4 influences cellular volume and ion homeostasis while 15-LOX1 contributes to the inflammatory response by oxidizing fatty acids.
Pathways
These proteins form key components in multiple signaling routes. TRPV1 and TRPV4 for instance contribute significantly to the transduction of sensory signaling pathways pertinent to pain and temperature regulation. The Glucocorticoid Receptor plays a part in the stress-adaptive HPA axis pathway linking with various other receptors. CYP3A4 and CYP2C9 are integral to the xenobiotic metabolism pathway where they relate closely to detoxification proteins like PXR. The Androgen Receptor significantly impacts the androgen signaling pathway directly influencing reproductive system development and maintenance. Gli3 occupies a space in the Hedgehog signaling pathway collaborating closely with other transcription factors.
Product promise
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