MW 734.7 Da, Purity >98%. Potent and selective κ opioid receptor antagonist. Achieve your results faster with highly validated, pure and trusted compounds.
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- Journal of molecular neuroscience : MN 74:32024The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChi Xu,Jiayu Ye,Yanting Sun,Xiujian Sun,Jing-Gen LiuPubMed 38183534
- Nature communications 14:79032023The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYu-Jun Wang,Gui-Ying Zan,Cenglin Xu,Xue-Ping Li,Xuelian Shu,Song-Yu Yao,Xiao-Shan Xu,Xiaoyun Qiu,Yexiang Chen,Kai Jin,Qi-Xin Zhou,Jia-Yu Ye,Yi Wang,Lin Xu,Zhong Chen,Jing-Gen LiuPubMed 38036497
- Molecules (Basel, Switzerland) 28:2023Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFumika Karaki,Taro Takamori,Koumei Kawakami,Sae Sakurai,Kyoko Hidaka,Kei Ishii,Tomoya Oki,Noriko Sato,Nao Atsumi,Karin Ashizawa,Ai Taguchi,Asuka Ura,Toko Naruse,Shigeto Hirayama,Miki Nonaka,Kanako Miyano,Yasuhito Uezono,Hideaki FujiiPubMed 37836768
- Journal of leukocyte biology 112:1317-13282022Morphine disrupts macrophage functions even during HIV infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJohn M Barbaro,Matias Jaureguiberry-Bravo,Simone Sidoli,Joan W BermanPubMed 36205434
- Pain research & management 2022:48199102022Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHuiying Huang,Xiaohui Bai,Kun Zhang,Jin Guo,Shaoyong Wu,Handong OuyangPubMed 35646201
- Neuroscience bulletin 38:403-4162022Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFu-Jun Zhai,Song-Ping Han,Tian-Jia Song,Ran Huo,Xing-Yu Lan,Rong Zhang,Ji-Sheng HanPubMed 35397112
- Communications biology 5:2992022Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuki Makino,Yuki Kamiyama,J B Brown,Toshiya Tanaka,Ryusuke Murakami,Yuki Teramoto,Takayuki Goto,Shusuke Akamatsu,Naoki Terada,Takahiro Inoue,Tatsuhiko Kodama,Osamu Ogawa,Takashi KobayashiPubMed 35365763
- Acta pharmacologica Sinica 43:1372-13822021Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuan-Yuan Wei,Yan Ma,Song-Yu Yao,Ling-Hui Kong,Xiao Liu,Jing-Rui Chai,Jing Chen,Wei Li,Yu-Jun Wang,Li-Ming Shao,Jing-Gen LiuPubMed 34493813
- Brain research 1719:64-702019Salvinorin A attenuates early brain injury through PI3K/Akt pathway after subarachnoid hemorrhage in rat.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJuan Sun et. al.PubMed 31125530
- Journal of medical virology 91:1158-11672019Transgenic increase in the β-endorphin concentration in cerebrospinal fluid alleviates morphine-primed relapse behavior through the μ opioid receptor in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan He et. al.PubMed 30701563
Key facts
- CAS number
113158-34-2
- Purity
> 98%
- Form
Solid
- Molecular weight
734.7 Da
- Molecular formula
C40H45Cl2N3O6
- PubChem identifier
11957626
- Nature
Synthetic
Recommended products
MW 734.7 Da, Purity >98%. Potent and selective κ opioid receptor antagonist. Achieve your results faster with highly validated, pure and trusted compounds.
Key facts
- CAS number
113158-34-2
- Purity
> 98%
- Form
Solid
- Molecular weight
734.7 Da
- Molecular formula
C40H45Cl2N3O6
- PubChem identifier
11957626
- Nature
Synthetic
- Solubility
Soluble in water to 50 mM.
- Biochemical name
nor-Binaltorphimine dihydrochloride
- Biological description
Potent and selective κ opioid receptor antagonist
- Canonical SMILES
C1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)C9C12CCN(C(C1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1.Cl.Cl
- Isomeric SMILES
C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1.Cl.Cl
- InChI
InChI=1S/C40H43N3O6.2ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;2*1H/t27-,28-,35+,36+,37+,38+,39-,40-;;/m1../s1
- InChIKey
JOJPJLHRMGPDPV-LZQROVCBSA-N
- IUPAC name
(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol;dihydrochloride
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (ab120078)
2D chemical structure image of ab120078, nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist
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