JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB120078

nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist

Be the first to review this product! Submit a review

|

(14 Publications)

Norbinaltorphimine dihydrochloride/nor-Binaltorphimine(CAS:113158-34-2)(ab120078) is a potent and selective kappa opioid receptor antagonist. MW 734.7, Purity >98%.

- Available in different sizes to fit your experimental needs. Larger volume format available upon request
1 Images
Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (AB120078)
  • Chemical Structure

Lab

Chemical Structure - nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist (AB120078)

2D chemical structure image of ab120078, nor-Binaltorphimine (nor-BNI), kappa opioid receptor antagonist

Key facts

CAS number

113158-34-2

Purity

>98%

Form

Solid

form

Molecular weight

734.7 Da

Molecular formula

C<sub>4</sub><sub>0</sub>H<sub>4</sub><sub>5</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>6</sub>

PubChem

11957626

Nature

Synthetic

Solubility

Soluble in water to 50 mM

Biochemical name

nor-Binaltorphimine dihydrochloride

Biological description

Potent and selective κ opioid receptor antagonist

Canonical smiles

C1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)C9C12CCN(C(C1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1.Cl.Cl

Isomeric smiles

C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=C(N6)[C@H]9[C@@]12CCN([C@@H]([C@@]1(C8)O)CC1=C2C(=C(C=C1)O)O9)CC1CC1.Cl.Cl

InChi

InChI=1S/C40H43N3O6.2ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;2*1H/t27-,28-,35+,36+,37+,38+,39-,40-;;/m1../s1

InChiKey

JOJPJLHRMGPDPV-LZQROVCBSA-N

IUPAC Name

(1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol;dihydrochloride

style
left-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Biochemicals

AB120084

Salvinorin A (Divinorin A), kappa agonist

Chemical Structure - Salvinorin A (Divinorin A), kappa agonist (AB120084)

  • 0
  • 0
Biochemicals

AB120669

BRL 52537 hydrochloride, kappa-opioid agonist

Chemical Structure - BRL 52537 hydrochloride, kappa-opioid agonist (AB120669)

  • 0
  • 0
Primary Antibodies

AB62341

Anti-RFP antibody

Lab Essentials

Western blot - Anti-RFP antibody (AB62341)

  • 4
  • 23
style
left-column

Product details

Check out our range of opioid antagonist biochemicals here
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

|

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (14)

Recent publications for all applications. Explore the full list and refine your search

BMC nephrology 26:307 PubMed40596915

2025

Anti-inflammatory and renoprotective effects of difelikefalin, a kappa opioid receptor agonist, in a rat model of renal ischemia-reperfusion-induced acute kidney injury.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroto Takeuchi,Satoshi Tatemichi,Yuji Okuhara

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 21:e00377 PubMed38777742

2024

A synthetic peptide exerts nontolerance-forming antihyperalgesic and antidepressant effects in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yongjiang Wu,Xiaofei Song,YanZhe Ji,Gang Chen,Long Zhao

Journal of molecular neuroscience : MN 74:3 PubMed38183534

2024

The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chi Xu,Jiayu Ye,Yanting Sun,Xiujian Sun,Jing-Gen Liu

Nature communications 14:7903 PubMed38036497

2023

The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Jun Wang,Gui-Ying Zan,Cenglin Xu,Xue-Ping Li,Xuelian Shu,Song-Yu Yao,Xiao-Shan Xu,Xiaoyun Qiu,Yexiang Chen,Kai Jin,Qi-Xin Zhou,Jia-Yu Ye,Yi Wang,Lin Xu,Zhong Chen,Jing-Gen Liu

Molecules (Basel, Switzerland) 28: PubMed37836768

2023

Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol.

Applications

Unspecified application

Species

Unspecified reactive species

Fumika Karaki,Taro Takamori,Koumei Kawakami,Sae Sakurai,Kyoko Hidaka,Kei Ishii,Tomoya Oki,Noriko Sato,Nao Atsumi,Karin Ashizawa,Ai Taguchi,Asuka Ura,Toko Naruse,Shigeto Hirayama,Miki Nonaka,Kanako Miyano,Yasuhito Uezono,Hideaki Fujii

Journal of leukocyte biology 112:1317-1328 PubMed36205434

2022

Morphine disrupts macrophage functions even during HIV infection.

Applications

Unspecified application

Species

Unspecified reactive species

John M Barbaro,Matias Jaureguiberry-Bravo,Simone Sidoli,Joan W Berman

Pain research & management 2022:4819910 PubMed35646201

2022

Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Huiying Huang,Xiaohui Bai,Kun Zhang,Jin Guo,Shaoyong Wu,Handong Ouyang

Neuroscience bulletin 38:403-416 PubMed35397112

2022

Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain.

Applications

Unspecified application

Species

Unspecified reactive species

Fu-Jun Zhai,Song-Ping Han,Tian-Jia Song,Ran Huo,Xing-Yu Lan,Rong Zhang,Ji-Sheng Han

Communications biology 5:299 PubMed35365763

2022

Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1.

Applications

Unspecified application

Species

Unspecified reactive species

Yuki Makino,Yuki Kamiyama,J B Brown,Toshiya Tanaka,Ryusuke Murakami,Yuki Teramoto,Takayuki Goto,Shusuke Akamatsu,Naoki Terada,Takahiro Inoue,Tatsuhiko Kodama,Osamu Ogawa,Takashi Kobayashi

Acta pharmacologica Sinica 43:1372-1382 PubMed34493813

2021

Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan-Yuan Wei,Yan Ma,Song-Yu Yao,Ling-Hui Kong,Xiao Liu,Jing-Rui Chai,Jing Chen,Wei Li,Yu-Jun Wang,Li-Ming Shao,Jing-Gen Liu
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com