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AB145050

NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist

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(3 Publications)

MW 445.4 Da, Purity >99%. Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects *in vivo.* Orally active.
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Chemical Structure - NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist (AB145050)
  • Chemical Structure

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Chemical Structure - NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist (AB145050)

2D chemical structure image of ab145050, NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist

Key facts

CAS number

324523-20-8

Purity

>99%

Form

Solid

form

Molecular weight

445.4 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>6</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

9868131

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 100 mM

Biochemical name

NPS 2143 hydrochloride

Biological description

Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects *in vivo.* Orally active.

Canonical smiles

CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O.Cl

Isomeric smiles

CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O.Cl

InChi

InChI=1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1

InChiKey

ZEBNDUQLNGYBNL-VEIFNGETSA-N

IUPAC Name

2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 15: PubMed40305220

2025

Calcium-Sensing Receptor as a Novel Target for the Treatment of Idiopathic Pulmonary Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Kasope Wolffs,Renjiao Li,Bethan Mansfield,Daniel A Pass,Richard T Bruce,Ping Huang,Rachel Paes de Araújo,Bahareh Sadat Haddadi,Luis A J Mur,Jordanna Dally,Ryan Moseley,Rupert Ecker,Harry Karmouty-Quintana,Keir E Lewis,A John Simpson,Jeremy P T Ward,Christopher J Corrigan,Renata Z Jurkowska,Benjamin D Hope-Gill,Daniela Riccardi,Polina L Yarova

Communications biology 7:501 PubMed38664468

2024

Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges.

Applications

Unspecified application

Species

Unspecified reactive species

Shumin Ma,Xueliang Yin,Jean-Philippe Pin,Philippe Rondard,Ping Yi,Jianfeng Liu

Science signaling 11: PubMed29463778

2018

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Caroline M Gorvin,Valerie N Babinsky,Tomas Malinauskas,Peter H Nissen,Anders J Schou,Aylin C Hanyaloglu,Christian Siebold,E Yvonne Jones,Fadil M Hannan,Rajesh V Thakker
View all publications
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