Skip to main content

MW 445.4 Da, Purity >99%. Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects *in vivo.* Orally active.

Be the first to review this product! Submit a review

Images

Chemical Structure - NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist (AB145050), expandable thumbnail

Publications

Key facts

CAS number
324523-20-8
Purity
> 99%
Form
Solid
Molecular weight
445.4 Da
Molecular formula
C24H26Cl2N2O2
PubChem identifier
9868131
Nature
Synthetic

Target data

Recommended products

MW 445.4 Da, Purity >99%. Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects *in vivo.* Orally active.

Key facts

Purity
> 99%
PubChem identifier
9868131
Solubility

Soluble in ethanol to 10 mM.

Soluble in DMSO to 100 mM.

Biochemical name
NPS 2143 hydrochloride
Biological description

Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects *in vivo.* Orally active.

Canonical SMILES
CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O.Cl
Isomeric SMILES
CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O.Cl
InChI
InChI=1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
InChIKey
ZEBNDUQLNGYBNL-VEIFNGETSA-N
IUPAC name
2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist (ab145050), expandable thumbnail

    Chemical Structure - NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist (ab145050)

    2D chemical structure image of ab145050, NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com