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MW 445.4 Da, Purity >99%. Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects *in vivo.* Orally active.

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Images

Chemical Structure - NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist (AB145050), expandable thumbnail

Publications

Key facts

CAS number
324523-20-8
Purity
> 99%
Form
Solid
Molecular weight
445.4 Da
Molecular formula
C24H26Cl2N2O2
PubChem identifier
9868131
Nature
Synthetic

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MW 445.4 Da, Purity >99%. Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects *in vivo.* Orally active.

Key facts

Purity
> 99%
PubChem identifier
9868131
Solubility

Soluble in ethanol to 10 mM.

Soluble in DMSO to 100 mM.

Biochemical name
NPS 2143 hydrochloride
Biological description

Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects *in vivo.* Orally active.

Canonical SMILES
CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O.Cl
Isomeric SMILES
CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O.Cl
InChI
InChI=1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
InChIKey
ZEBNDUQLNGYBNL-VEIFNGETSA-N
IUPAC name
2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist (ab145050), expandable thumbnail

    Chemical Structure - NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist (ab145050)

    2D chemical structure image of ab145050, NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist

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Product protocols

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