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AB120371

NS309, K+ channel activator

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(2 Publications)

MW 231.03 Da, Purity >98%. Potent activator of human Ca2+ -activated K+ channels of SK and IK types, selective over BK type channels (EC50 = 10 nM for increasing hIK current). At least 1000 times more potent than 1-EBIO (ab120258). Can be used in conjunction with CyPPA (ab120829) to distinguish SK1 and SK3 subtypes.
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Chemical Structure - NS309, K+ channel activator (AB120371)
  • Chemical Structure

Lab

Chemical Structure - NS309, K+ channel activator (AB120371)

2D chemical structure image of ab120371, NS309, K+ channel activator

Key facts

Purity

>98%

Form

Solid

form

Molecular weight

231.03 Da

Molecular formula

C<sub>8</sub>H<sub>4</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

11637204

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

CID 11637204

Biological description

Potent activator of human Ca2+ -activated K+ channels of SK and IK types, selective over BK type channels (EC50 = 10 nM for increasing hIK current). At least 1000 times more potent than 1-EBIO (ab120258). Can be used in conjunction with CyPPA (ab120829) to distinguish SK1 and SK3 subtypes.

Canonical smiles

C1=CC(=C(C2=NC(=O)C(=C21)NO)Cl)Cl

Isomeric smiles

C1=CC(=C(C2=NC(=O)C(=C21)NO)Cl)Cl

InChi

InChI=1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)

InChiKey

CVOUSAVHMDXCKG-UHFFFAOYSA-N

IUPAC Name

6,7-dichloro-3-(hydroxyamino)indol-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Open life sciences 17:1043-1052 PubMed36118166

2022

Effects of KCa channels on biological behavior of trophoblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaolei Zhang,Meitao Yang,Dan Lv,Yin Xie,Yanan Sun,Yanling Zhang,Mengzhou He,Haiyi Liu,Fanfan Li,Dongrui Deng

BioMed research international 2018:2925985 PubMed29511675

2018

Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide.

Applications

Unspecified application

Species

Unspecified reactive species

Mingshuai Wang,Nianzeng Xing,Liyang Wu,Wen-Chu Huang,Zhenqun Xu,Guiming Liu
View all publications
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