MW 316.8 Da, Purity >98%. Cell-permeable p53 activator. Genotype-selective antitumor agent. Active in vitro.
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Key facts
- CAS number
- 59474-01-0
- Purity
- > 98%
- Molecular weight
- 316.8 Da
- Molecular formula
- C17H17ClN2S
- PubChem identifier
- 16759161
- Nature
- Synthetic
Recommended products
MW 316.8 Da, Purity >98%. Cell-permeable p53 activator. Genotype-selective antitumor agent. Active in vitro.
Key facts
- CAS number
- 59474-01-0
- Purity
- > 98%
- Molecular weight
- 316.8 Da
- Molecular formula
- C17H17ClN2S
- PubChem identifier
- 16759161
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 10 mM.
- Biochemical name
- (10-Methylanthracen-9-yl)methyl carbamimidothioate hydrochloride
- Biological description
Cell-permeable p53 activator. Genotype-selective antitumor agent. Active in vitro.
- Canonical SMILES
- CC1=C2C=CC=CC2=C(C3=CC=CC=C13)CSC(=N)N.Cl
- InChI
- InChI=1S/C17H16N2S.ClH/c1-11-12-6-2-4-8-14(12)16(10-20-17(18)19)15-9-5-3-7-13(11)15;/h2-9H,10H2,1H3,(H3,18,19);1H
- InChIKey
- VIBMUYOXJUCEMA-UHFFFAOYSA-N
- IUPAC name
- (10-methylanthracen-9-yl)methyl carbamimidothioate;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 1907 NSC 146109 hydrochloride. 1907-5 is the same size as the 5 mg size of ab142144.
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2 product images
Chemical Structure - NSC 146109 hydrochloride, Cell-permeable p53 activator (ab142144)
2D chemical structure image of ab142144, NSC 146109 hydrochloride, Cell-permeable p53 activator
Functional Studies - NSC 146109 hydrochloride, Cell-permeable p53 activator (ab142144)
Anti-p53 antibody [PAb 240] ab26 staining p53 in U20S cells treated with NSC 146109 hydrochloride (ab142144), by ICC/IF. Increase in p53 expression correlates with increased concentration of NSC 146109 hydrochloride, as described in literature.
The cells were incubated at 37°C for 5 hour in media containing different concentrations of ab142144 (NSC 146109 hydrochloride) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-p53 antibody [PAb 240] ab26 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (Goat Anti-Mouse IgG H&L (DyLight® 488) preadsorbed ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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