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AB142161

NSC 23766 trihydrochloride, Rac-1 inhibitor

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(5 Publications)

MW 531 Da, Purity >98%. Selective Rac-1 inhibitor. Blocks Rac-specific guanine nucleotide exchange factors TrioN and Tiam1 (IC50 = 50 μM) without affecting Cdc42 or RhoA activation. Apoptotic and causes G1 cell cycle arrest in vitro. Cell-permeable. Active in vivo and centrally active.
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Chemical Structure - NSC 23766 trihydrochloride, Rac-1 inhibitor (AB142161)
  • Chemical Structure

Lab

Chemical Structure - NSC 23766 trihydrochloride, Rac-1 inhibitor (AB142161)

2D chemical structure image of ab142161, NSC 23766 trihydrochloride, Rac-1 inhibitor

Key facts

CAS number

733767-34-5

Purity

>98%

Form

Solid

form

Molecular weight

531 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>3</sub><sub>8</sub>Cl<sub>3</sub>N<sub>7</sub>

PubChem

16759159

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

NSC 23766 trihydrochloride

Biological description

Selective Rac-1 inhibitor. Blocks Rac-specific guanine nucleotide exchange factors TrioN and Tiam1 (IC50 = 50 μM) without affecting Cdc42 or RhoA activation. Apoptotic and causes G1 cell cycle arrest in vitro. Cell-permeable. Active in vivo and centrally active.

Canonical smiles

CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C(N=C3C=C2)C)N)C.Cl.Cl.Cl

InChi

InChI=1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H

InChiKey

CPUHORIUXPQCHW-UHFFFAOYSA-N

IUPAC Name

6-N-[2-[5-(diethylamino)pentan-2-ylamino]-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine;trihydrochloride

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Biochemicals

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Assay Kits

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Science advances 8:eabq0866 PubMed36129975

2022

Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery.

Applications

Unspecified application

Species

Unspecified reactive species

Ken Hiratsuka,Tomoya Miyoshi,Katharina T Kroll,Navin R Gupta,M Todd Valerius,Thomas Ferrante,Michifumi Yamashita,Jennifer A Lewis,Ryuji Morizane

Development (Cambridge, England) 149: PubMed35420656

2022

Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaorei Sai,Yayoi Ikawa,Hiromi Nishimura,Katsutoshi Mizuno,Eriko Kajikawa,Takanobu A Katoh,Toshiya Kimura,Hidetaka Shiratori,Katsuyoshi Takaoka,Hiroshi Hamada,Katsura Minegishi

Pain 163:2138-2153 PubMed35384934

2022

Altered pain sensitivity in 5×familial Alzheimer disease mice is associated with dendritic spine loss in anterior cingulate cortex pyramidal neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengyu Cui,Zhongzhao Guo,Luyao Wei,Xiang Zou,Zilu Zhu,Yuchen Liu,Jie Wang,Liang Chen,Deheng Wang,Zunji Ke

Molecular medicine reports 24: PubMed34109430

2021

MicroRNA‑142‑3p suppresses cell proliferation, invasion and epithelial‑to‑mesenchymal transition via RAC1‑ERK1/2 signaling in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Na Xie,Qiuping Meng,Yixin Zhang,Zhifei Luo,Fenggui Xue,Sisi Liu,Ying Li,Yousheng Huang

Microorganisms 8: PubMed32645930

2020

Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport.

Applications

Unspecified application

Species

Unspecified reactive species

Oleksandr Kolyvushko,Maximilian A Kelch,Nikolaus Osterrieder,Walid Azab
View all publications
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