NSC 663284 (DA3003-1), Cdc25 inhibitor (CAS 383907-43-5) (ab144408)

MW 321.76 Da, Purity >98%. Potent, cell-permeable, irreversible non-selective Cdc25 inhibitor. Induces cell cycle arrest at both G1 and G2/M phase. Shows antiproliferative effects against tumor cell lines (IC₅₀ = 0.2-35 μM). Shows antitumor effects in vivo. .

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Alternative names=AI604853, CDC25A, CDC25A2, CDC25A2 CAG isoform, CDC25HU2, Cdc 25B, Cdc 25C, Cdc25m2, Cell division cycle 25 homolog A (S. pombe), Cell division cycle 25 homolog B, Cell division cycle 25 homolog C, Cell division cycle 25A, Cell division cycle 25A isoform a, Cell division cycle 25A isoform b, Cell division cycle 25B, Cell division cycle 25B isoform 1, Cell division cycle 25B isoform 2, Cell division cycle 25B isoform 3, Cell division cycle 25B isoform 4, Cell division cycle 25B isoform 5, Cell division cycle 25C, Cell division cycle 25C protein, D9Ertd393e, Dual specificity phosphatase Cdc25A, Dual specificity phosphatase Cdc25B, Dual specificity phosphatase Cdc25C, EC 3.1.3.48, H4 K20 specific histone methyltransferase, H4-K20-HMTase, H4-K20-HMTase SETD8, Histone H4 K20 methyltransferase, Histone lysine N methyltransferase H4 lysine 20 specific, Histone-lysine N-methyltransferase SETD8, Lysine N-methyltransferase 5A, M-phase inducer phosphatase 1, M-phase inducer phosphatase 2, M-phase inducer phosphatase 3, MGC115549, MPIP1_HUMAN, MPIP2_HUMAN, MPIP3_HUMAN, Mitosis inducer CDC25, N-lysine methyltransferase SETD8, PPP1R60, PR-Set7, PR/SET domain containing protein 8, PR/SET domain-containing protein 07, PR/SET07, Phosphotyrosine phosphatase, Pr SET 7, PrSET7, SET 07, SET 8, SET domain containing (lysine methyltransferase) 8, SET domain containing 8, SET domain containing lysine methyltransferase 8, SET domain-containing protein 8, SETD 8, SETD8_HUMAN, protein phosphatase 1, regulatory subunit 60

CAS number: 383907-43-5
Purity: > 98%
Form: Solid
Molecular weight: 321.76 Da
Molecular formula: C₁₅H₁₆ClN₃O₃
PubChem identifier: 379077
Nature: Synthetic

Target data

6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione

Key facts

CAS number: 383907-43-5
Purity: > 98%
Form: Solid
Molecular weight: 321.76 Da
Molecular formula: C₁₅H₁₆ClN₃O₃
PubChem identifier: 379077
Nature: Synthetic
Biochemical name: 6-Chloro-7-{[2-(morpholin-4-yl)ethyl]amino}quinoline-5,8-dione
Biological description: Potent, cell-permeable, irreversible non-selective Cdc25 inhibitor. Induces cell cycle arrest at both G1 and G2/M phase. Shows antiproliferative effects against tumor cell lines (IC₅₀ = 0.2-35 μM). Shows antitumor effects in vivo.
Canonical SMILES: C1COCCN1CCNC2=C(C(=O)C3=C(C2=O)N=CC=C3)Cl
InChI: InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
InChIKey: BMKPVDQDJQWBPD-UHFFFAOYSA-N
IUPAC name: 6-chloro-7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione

Storage

Shipped at conditions: Ambient - Can Ship with Ice
Appropriate long-term storage conditions: -20°C
Storage information: Store under desiccating conditions, The product can be stored for up to 12 months

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NSC 663284 (DA3003-1), Cdc25 inhibitor

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