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MW 419.4 Da, Purity >98%. Cell-permeable USP14 and UCHL5 inhibitor. Apoptotic agent. Induces mitochondrial apoptosis via cathepsin D-dependent caspase-cleavage. Shows antitumor effects in vivo..
- CAS number
1009817-63-3
- Purity
> 98%
- Form
Solid
- Molecular weight
419.4 Da
- Molecular formula
C22H17N3O6
- PubChem identifier
5351435
- Nature
Synthetic
Recommended products
MW 419.4 Da, Purity >98%. Cell-permeable USP14 and UCHL5 inhibitor. Apoptotic agent. Induces mitochondrial apoptosis via cathepsin D-dependent caspase-cleavage. Shows antitumor effects in vivo..
Key facts
- CAS number
1009817-63-3
- Purity
> 98%
- Form
Solid
- Molecular weight
419.4 Da
- Molecular formula
C22H17N3O6
- PubChem identifier
5351435
- Nature
Synthetic
- Biochemical name
(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one
- Biological description
Cell-permeable USP14 and UCHL5 inhibitor. Apoptotic agent. Induces mitochondrial apoptosis via cathepsin D-dependent caspase-cleavage. Shows antitumor effects in vivo.
- Canonical SMILES
C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1
- Isomeric SMILES
C=CC(=O)N1C/C(=C\C2=CC=C(C=C2)[N+](=O)[O-])/C(=O)/C(=C/C3=CC=C(C=C3)[N+](=O)[O-])/C1
- InChI
InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+
- InChIKey
GFARQYQBWJLZMW-JYFOCSDGSA-N
- IUPAC name
(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 2021 NSC-687852. 2021-25 is the same size as the 25 mg size of ab142195.
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