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AB142195

NSC-687852, USP14 and UCHL5 inhibitor

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MW 419.4 Da, Purity >98%. Cell-permeable USP14 and UCHL5 inhibitor. Apoptotic agent. Induces mitochondrial apoptosis via cathepsin D-dependent caspase-cleavage. Shows antitumor effects in vivo..

Key facts

CAS number

1009817-63-3

Purity

>98%

Form

Solid

form

Molecular weight

419.4 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>1</sub><sub>7</sub>N<sub>3</sub>O<sub>6</sub>

PubChem

5351435

Nature

Synthetic

Solubility

Soluble in DMSO to 75 mM

Biochemical name

(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one

Biological description

Cell-permeable USP14 and UCHL5 inhibitor. Apoptotic agent. Induces mitochondrial apoptosis via cathepsin D-dependent caspase-cleavage. Shows antitumor effects in vivo.

Canonical smiles

C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1

Isomeric smiles

C=CC(=O)N1C/C(=C\C2=CC=C(C=C2)[N+](=O)[O-])/C(=O)/C(=C/C3=CC=C(C=C3)[N+](=O)[O-])/C1

InChi

InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+

InChiKey

GFARQYQBWJLZMW-JYFOCSDGSA-N

IUPAC Name

(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one

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Biochemicals

AB120596

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2021 NSC-687852. 2021-25 is the same size as the 25 mg size of ab142195.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Product promise

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