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MW 419.4 Da, Purity >98%. Cell-permeable USP14 and UCHL5 inhibitor. Apoptotic agent. Induces mitochondrial apoptosis via cathepsin D-dependent caspase-cleavage. Shows antitumor effects in vivo..

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Key facts

CAS number
1009817-63-3
Purity
> 98%
Form
Solid
Molecular weight
419.4 Da
Molecular formula
C22H17N3O6
PubChem identifier
5351435
Nature
Synthetic

Target data

Recommended products

MW 419.4 Da, Purity >98%. Cell-permeable USP14 and UCHL5 inhibitor. Apoptotic agent. Induces mitochondrial apoptosis via cathepsin D-dependent caspase-cleavage. Shows antitumor effects in vivo..

Key facts

Purity
> 98%
PubChem identifier
5351435
Solubility

Soluble in DMSO to 75 mM.

Biochemical name
(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one
Biological description

Cell-permeable USP14 and UCHL5 inhibitor. Apoptotic agent. Induces mitochondrial apoptosis via cathepsin D-dependent caspase-cleavage. Shows antitumor effects in vivo.

Canonical SMILES
C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1
Isomeric SMILES
C=CC(=O)N1C/C(=C\C2=CC=C(C=C2)[N+](=O)[O-])/C(=O)/C(=C/C3=CC=C(C=C3)[N+](=O)[O-])/C1
InChI
InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+
InChIKey
GFARQYQBWJLZMW-JYFOCSDGSA-N
IUPAC name
(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 2021 NSC-687852. 2021-25 is the same size as the 25 mg size of ab142195.

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