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AB144316

NSC697923, UBE2N inhibitor

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MW 267.26 Da, Purity >98%. Selective, cell-permeable UBE2N inhibitor. Inhibits E2 complex Ubc13-Uev1A. Inhibits NF-κB activation. Induces nuclear accumulation of p53 and apoptosis. Shows potent cytotoxic effects to neuroblastoma cell lines. Shows antitumor effects in vivo. .
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Chemical Structure - NSC697923, UBE2N inhibitor (AB144316)
  • Chemical Structure

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Chemical Structure - NSC697923, UBE2N inhibitor (AB144316)

2D chemical structure image of ab144316, NSC697923, UBE2N inhibitor

Key facts

CAS number

343351-67-7

Purity

>98%

Form

Solid

form

Molecular weight

267.26 Da

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>9</sub>NO<sub>5</sub>S

PubChem

394449

Nature

Synthetic

Solubility

Soluble in ethanol to 25 mM (with gentle warming)

Soluble in DMSO to 100 mM

Biochemical name

2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran

Biological description

Selective, cell-permeable UBE2N inhibitor. Inhibits E2 complex Ubc13-Uev1A. Inhibits NF-κB activation. Induces nuclear accumulation of p53 and apoptosis. Shows potent cytotoxic effects to neuroblastoma cell lines. Shows antitumor effects in vivo.

Canonical smiles

CC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(O2)[N+](=O)[O-]

InChi

InChI=1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3

InChiKey

GAUHIPWCDXOLCZ-UHFFFAOYSA-N

IUPAC Name

2-(4-methylphenyl)sulfonyl-5-nitrofuran

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Biochemicals

AB145522

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Chemical Structure - TPCA 1, IkappaB kinase inhibitor (AB145522)

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Biochemicals

AB142825

Amlexanox, TBK1 and IKKepsilon inhibitor

Chemical Structure - Amlexanox, TBK1 and IKKepsilon inhibitor (AB142825)

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Proteins & Peptides

AB51426

Recombinant human PLK1 protein

Functional Studies - Recombinant human PLK1 protein (AB51426)

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Primary Antibodies

AB17056

Anti-PLK1 antibody [35-206]

Trial Size

Flow Cytometry (Intracellular) - Anti-PLK1 antibody [35-206] (AB17056)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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