MW 281.3 Da, Purity >99%. Novel, specific, reversible DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 = 0.23 μM). Increases G2/M arrest and inhibits double-strand break repair.
Images
Publications
Filter by
- Cancer discovery 13:880-9092023Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPrashanthi Dharanipragada,Xiao Zhang,Sixue Liu,Shirley H Lomeli,Aayoung Hong,Yan Wang,Zhentao Yang,Kara Z Lo,Agustin Vega-Crespo,Antoni Ribas,Stergios J Moschos,Gatien Moriceau,Roger S LoPubMed 36700848
- Scientific reports 8:38502018Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJulien Brustel et. al.PubMed 29497062
- The Journal of biological chemistry 289:28730-72014Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMitsuo Wakasugi et. al.PubMed 25164823
Key facts
- CAS number
- 154447-35-5
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 281.3 Da
- Molecular formula
- C17H15NO3
- PubChem identifier
- 9860529
- Nature
- Synthetic
Alternative names
DNA PK, DNA-PK catalytic subunit, DNA-PKcs, DNA-dependent protein kinase catalytic subunit, DNPK 1, HYRC, HYRC 1, Hyper radiosensitivity of murine scid mutation, complementing 1, Hyperradiosensitivity complementing 1, mouse, homolog of 1, IMD26, PKRDC, PRKDC_HUMAN, Protein Kinase DNA Activated Catalytic Polypeptide, XRCC 7, p350, p460
Recommended products
MW 281.3 Da, Purity >99%. Novel, specific, reversible DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 = 0.23 μM). Increases G2/M arrest and inhibits double-strand break repair.
Key facts
- CAS number
- 154447-35-5
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 281.3 Da
- Molecular formula
- C17H15NO3
- PubChem identifier
- 9860529
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 10 mM.
- Biochemical name
- 2-(Morpholin-4-yl)-benzo[h]chromen-4-one
- Biological description
Novel, specific, reversible DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 = 0.23 μM). Increases G2/M arrest and inhibits double-strand break repair.
- Canonical SMILES
- C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
- InChI
- InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
- InChIKey
- KKTZALUTXUZPSN-UHFFFAOYSA-N
- IUPAC name
- 2-morpholin-4-ylbenzo[h]chromen-4-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
DNA-dependent protein kinase catalytic subunit often abbreviated as DNA-PKcs or PKcs is an important component in the cellular machinery responsible for DNA repair. This protein weighs approximately 470 kDa and is predominantly expressed in various tissue types with higher levels found in lymphoid tissues. The DNA-PKcs functions as a serine/threonine protein kinase and becomes active upon binding to DNA contributing to its role in maintaining genome integrity.
- Biological function summary
DNA-PKcs plays an essential role in the non-homologous end joining (NHEJ) repair pathway which repairs double-strand breaks in DNA. DNA-PKcs forms a complex with the Ku70/80 heterodimer serving as a critical component of the DNA repair mechanism. This complex recognizes DNA ends facilitates their synapsis and activates other enzymes involved in ligating the broken DNA strands therefore promoting cellular survival following DNA damage.
- Pathways
DNA-PKcs deeply integrates into the DNA damage response pathway. It collaborates closely with proteins such as ATM (ataxia-telangiectasia mutated) to sense DNA damage and initiate repair. DNA-PKcs is involved in V(D)J recombination vital for the generation of diverse antibodies in immune cells. Its activity is essential for coordinating with other proteins including XRCC4 and Ligase IV to ensure efficient DNA repair processes are executed.
- Associated diseases and disorders
Defects in DNA-PKcs are linked to severe combined immunodeficiency (SCID) due to its central role in V(D)J recombination. Dysfunction in its pathway also relates to cancer where impaired DNA repair mechanisms substantially increase genomic instability leading to tumorigenesis. DNA-PKcs interacts with other proteins like BRCA1 and p53 in tumors where its overexpression or mutations can contribute to resistance against radiation and chemotherapeutic agents. These interactions highlight the importance of DNA-PK inhibitors as potential therapeutic strategies in oncology.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Chemical Structure - NU 7026, DNA-PK inhibitor (ab120970)
2D chemical structure image of ab120970, NU 7026, DNA-PK inhibitor
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com