NU6102, CDK1/cyclin B and CDK2/cyclin A3 inhibitor

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MW 402.5 Da, Purity >98%. Potent CDK1/cyclin B and CDK2/cyclin A3 inhibitor (IC50 values are 9.5 and 5.4 nM for CDK1/cyclin B and CDK2/cyclin A3 respectively). Antiproliferative agent. Inhibits CDK4/D1, DYRK1A, PDK1 ROCKII (IC50 values are 1.6, 0.9, 0.8 and 0.6 μM respectively). Induces G2/M cell cycle arrest. Shows antitumor effects *in vivo.*.

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C-2K, C85740, CCNA, CCNA1_HUMAN, CCNA2_HUMAN, CCNB, CCNB1_HUMAN, CCNB2_HUMAN, CCNE, CCNE1_HUMAN, CDC28, CDC28A, CDC2A, CDC2L4, CDK1_HUMAN, CDK2_HUMAN, CDK4 protein, CDK4_HUMAN, CDK5_HUMAN, CDK9_HUMAN, CDKN1, CDKN2, CELL CYCLE CONTROLLER CDC2, CHEK 1, CHK1 checkpoint homolog (S. pombe), CHK1_HUMAN, CMM 3, Cdc 2, Cdc2-related kinase, Cell Divsion Cycle 2 Protein, Cell cycle checkpoint kinase, Cell devision kinase 2, Cell division control protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2 to M, Cell division cycle 2-like protein kinase 4, Cell division kinase 4, Cell division protein kinase 1, Cell division protein kinase 2, Cell division protein kinase 4, Cell division protein kinase 5, Cell division protein kinase 9, Checkpoint , S. pombe, homolog of, 1, Checkpoint kinase 1, Checkpoint kinase 1 homolog (S. pombe), Crk3, Crk6, CycB2, Cyclin B1, Cyclin B2, Cyclin E1, Cyclin Es, Cyclin Et, Cyclin-A, Cyclin-A1, Cyclin-A2, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4, Cyclin-dependent kinase 5, Cyclin-dependent kinase 9, CyclinE, DKFZp686L20222, DYR1A_HUMAN, DYRK, DYRK 1, DYRKA, Dual specificity YAK 1 related kinase, Dual specificity YAK1-related kinase, Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A, Dual specificity tyrosine phosphorylation regulated kinase, Dual specificity tyrosine phosphorylation regulated kinase 1, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, EC 2.7.11.1, G1/S specific cyclin E, G1/S-specific cyclin-E1, G2 mitotic specific cyclin B1, G2 mitotic specific cyclin B2, G2/mitotic specific cyclin A1, G2/mitotic specific cyclin B3, G2/mitotic-specific cyclin-B1, G2/mitotic-specific cyclin-B2, GSK-3 beta, GSK3B_HUMAN, GSK3beta isoform, Glycogen synthase kinase-3 beta, HGNC:8809, HP 86, HsT17299, KIAA0619, MGC108931, MGC111195, MGC132235, MGC140694, MGC14458, MGC159139, MNB, MNB protein kinase, MNB protein kinase, Serine/threonine-specific, MNB/DYRK protein kinase, MNBH, MPF, MRD7, Melanoma cutaneous malignant 3, Minibrain (Drosophila) homolog, Minibrain homolog, Minibrain, Drosophila, homolog of, Mitochondrial pyruvate dehydrogenase kinase isoenzyme 1, Mnb protein kinase homolog hp86, OTTHUMP00000109090, OTTHUMP00000109091, OTTHUMP00000109094, OTTHUMP00000174799, P34CDC2, PDH kinase 1, PDK1_HUMAN, PITALRE, PSK-J3, PSSALRE, Protein kinase CDK5 splicing, Protein kinase minibrain homolog, Pyruvate dehydrogenase kinase isoform 1, Pyruvate dehydrogenase kinase, isoenzyme 1, ROCK2_HUMAN, ROK alpha, RP11 805H4.3, Rho associated coiled coil containing protein kinase 2, Rho associated, coiled coil containing protein kinase II, Rho kinase 2, Rho-associated, Rho-associated protein kinase 2, Rock II, Rock2m, STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae), Serine threonine protein kinase PSSALRE, Serine/threonine kinase MNB, Serine/threonine-protein kinase CHK1, Serine/threonine-protein kinase GSK3B, Serine/threonine-protein kinase PITALRE, Serine/threonine-protein kinase PSSALRE, TAK, TPKII catalytic subunit, Tat associated kinase complex catalytic subunit, Tau protein kinase II catalytic subunit, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial, cdc2-related protein kinase, coiled-coil-containing protein kinase 2, cyclin E variant ex5del, cyclin E variant ex7del, cyclin dependent kinase 2-alpha, hMNB, kinase Cdc2, p164 ROCK-2, p33 protein kinase, p33(CDK2), p34 Cdk1, p34 cdk4, p34 protein kinase, rad27