JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB144317

NU6102, CDK1/cyclin B and CDK2/cyclin A3 inhibitor

Be the first to review this product! Submit a review

|

(0 Publication)

MW 402.5 Da, Purity >98%. Potent CDK1/cyclin B and CDK2/cyclin A3 inhibitor (IC50 values are 9.5 and 5.4 nM for CDK1/cyclin B and CDK2/cyclin A3 respectively). Antiproliferative agent. Inhibits CDK4/D1, DYRK1A, PDK1 ROCKII (IC50 values are 1.6, 0.9, 0.8 and 0.6 μM respectively). Induces G2/M cell cycle arrest. Shows antitumor effects *in vivo.*.
1 Images
Chemical Structure - NU6102, CDK1/cyclin B and CDK2/cyclin A3 inhibitor (AB144317)
  • Chemical Structure

Lab

Chemical Structure - NU6102, CDK1/cyclin B and CDK2/cyclin A3 inhibitor (AB144317)

2D chemical structure image of ab144317, NU6102, CDK1/cyclin B and CDK2/cyclin A3inhibitor

Key facts

CAS number

444722-95-6

Purity

>98%

Form

Solid

form

Molecular weight

402.5 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>2</sub><sub>2</sub>N<sub>6</sub>O<sub>3</sub>S

PubChem

4566

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine

Biological description

Potent CDK1/cyclin B and CDK2/cyclin A3 inhibitor (IC50 values are 9.5 and 5.4 nM for CDK1/cyclin B and CDK2/cyclin A3 respectively). Antiproliferative agent. Inhibits CDK4/D1, DYRK1A, PDK1 ROCKII (IC50 values are 1.6, 0.9, 0.8 and 0.6 μM respectively). Induces G2/M cell cycle arrest. Shows antitumor effects *in vivo.*

Canonical smiles

C1CCC(CC1)COC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)S(=O)(=O)N

InChi

InChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)22-18-23-16-15(20-11-21-16)17(24-18)27-10-12-4-2-1-3-5-12/h6-9,11-12H,1-5,10H2,(H2,19,25,26)(H2,20,21,22,23,24)

InChiKey

OWXORKPNCHJYOF-UHFFFAOYSA-N

IUPAC Name

4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]benzenesulfonamide

style
left-column

Complementary Products

Biochemicals

AB141453

Puromycin dihydrochloride, Protein biosynthesis inhibitor

Chemical Structure - Puromycin dihydrochloride, Protein biosynthesis inhibitor (AB141453)

  • 0
  • 0
Biochemicals

AB141003

MG-132, proteasome inhibitor

Immunocytochemistry/ Immunofluorescence - MG-132, proteasome inhibitor (AB141003)

  • 5
  • 1
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 16
Biochemicals

AB144598

Epoxomicin, 20S proteasome inhibitor

Chemical Structure - Epoxomicin, 20S proteasome inhibitor (AB144598)

  • 0
  • 0
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com