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AB120646

(±)-Nutlin-3, MDM2 antagonist

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(3 Publications)

MW 581.5 Da, Purity >98%. Achieve your results faster with highly validated, pure and trusted compounds.
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Chemical Structure - (±)-Nutlin-3, MDM2 antagonist (AB120646)
  • Chemical Structure

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Chemical Structure - (±)-Nutlin-3, MDM2 antagonist (AB120646)

2D chemical structure image of ab120646, Nutlin-3, MDM2 antagonist

Key facts

CAS number

548472-68-0

Purity

>98%

Form

Solid

form

Molecular weight

581.5 Da

Molecular formula

C<sub>3</sub><sub>0</sub>H<sub>3</sub><sub>0</sub>Cl<sub>2</sub>N<sub>4</sub>O<sub>4</sub>

PubChem

216345

Nature

Synthetic

Solubility

100 mM

Biochemical name

4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

InChi

InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)

IUPAC Name

4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Medical science monitor : international medical journal of experimental and clinical research 27:e928375 PubMed34050122

2021

Silencing Ribosomal Protein L22 Promotes Proliferation and Migration, and Inhibits Apoptosis of Gastric Cancer Cells by Regulating the Murine Double Minute 2-Protein 53 (MDM2-p53) Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenqing Sun,Zhigang Qiu,Zhengkun Wang,Honghui Chi,Peipei Shan

Neuroscience letters 513:106-10 PubMed22343310

2012

MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Ghassemifar,Susan M Mendrysa

Annual review of pharmacology and toxicology 49:223-41 PubMed18834305

2008

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Sanjeev Shangary,Shaomeng Wang
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