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AB144428

(-)-Nutlin-3, p53-MDM2 binding inhibitor

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MW 581.5 Da, Purity >98%. Potent p53-MDM2 binding inhibitor (IC50 = 90 nM). Enantiomer of (+)-Nutlin-3 (ab144426). Shows antiproliferative effects (IC50 values are 2.2 and 1.3 µM for human skin and murine fibroblasts respectively). Shows antitumor effects *in vivo.* Orally active.

View Alternative Names

ACTFS, Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, FLJ92943, HDMX, Hdm 2, LFS1, MDM2 oncogene E3 ubiquitin protein ligase, MDM2BP, MDM2_HUMAN, Mdm2 p53 E3 ubiquitin protein ligase homolog, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa, Mouse Double Minute 2, Murine Double Minute Chromosome 2, Mutant tumor protein 53, Oncoprotein Mdm2, P53_HUMAN, Phosphoprotein p53, TRP53, Tp53, Transformation related protein 53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Ubiquitin protein ligase E3 Mdm2, p53 tumor suppressor, p53-binding protein Mdm2, tumor antigen p55

1 Images
Chemical Structure - (-)-Nutlin-3, p53-MDM2 binding inhibitor (AB144428)
  • Chemical Structure

Lab

Chemical Structure - (-)-Nutlin-3, p53-MDM2 binding inhibitor (AB144428)

2D chemical structure image of ab144428, (-)-Nutlin-3, p53-MDM2 binding inhibitor

Key facts

CAS number

675576-98-4

Purity

>98%

Form

Solid

form

Molecular weight

581.5 Da

Molecular formula

C<sub>3</sub><sub>0</sub>H<sub>3</sub><sub>0</sub>Cl<sub>2</sub>N<sub>4</sub>O<sub>4</sub>

PubChem

11433190

Nature

Synthetic

Solubility

Soluble in DMSO

Biochemical name

nutlin-3A

Biological description

Potent p53-MDM2 binding inhibitor (IC50 = 90 nM). Enantiomer of (+)-Nutlin-3 (ab144426). Shows antiproliferative effects (IC50 values are 2.2 and 1.3 µM for human skin and murine fibroblasts respectively). Shows antitumor effects *in vivo.* Orally active.

Canonical smiles

CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Isomeric smiles

CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChi

InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1

InChiKey

BDUHCSBCVGXTJM-WUFINQPMSA-N

IUPAC Name

4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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