NVP-BEZ235, PI3K and mTOR inhibitor

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MW 469.5 Da, Purity >98%. Potent, ATP-competitive Phosphatidylinositol 3-​kinase (PI3K) inhibitor (IC₅₀ = 4, 5, 7 and 75 nM for PI3Kα, -γ, -δ, and -β respectively) and mTOR inhibitor. Able to directly induce G₁ arrest and inhibit angiogenesis in vitro and potentiate the efficacy of other anticancer agents in vivo.

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1-phosphatidylinositol 3-kinase, 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, 5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, 5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, 5-bisphosphate 3-kinase catalytic subunit alpha isoform, 5-bisphosphate 3-kinase catalytic subunit beta isoform, 5-bisphosphate 3-kinase catalytic subunit delta isoform, 5-bisphosphate 3-kinase catalytic subunit gamma isoform, AI838772, APDS, AW493413, CLOVE, CWS5, DKFZp779K1237, FK506 binding protein 12 rapamycin associated protein 1, FK506 binding protein 12 rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP rapamycin associated protein, FKBP12-rapamycin complex-associated protein, FKBP12-rapamycin complex-associated protein 1, FLJ11090, FLJ44809, FRAP, FRAP1, FRAP2, GRB 1, IMD14, MCAP, MCM, MCMTC, MGC104252, MGC112732, MGC133043, MGC142161, MGC142163, MTOR_HUMAN, Mammalian target of rapamycin, Mechanistic target of rapamycin, NF-E2-related factor 2, NF2L2_HUMAN, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, OTTHUMP00000001983, OTTHUMP00000216901, OTTHUMP00000216904, PI 3 Kinase catalytic subunit alpha, PI 3 Kinase catalytic subunit gamma, PI3 kinase p110 subunit alpha, PI3 kinase p110 subunit beta, PI3 kinase p110 subunit delta, PI3 kinase p110 subunit gamma, PI3-kinase subunit alpha, PI3-kinase subunit beta, PI3-kinase subunit delta, PI3-kinase subunit gamma, PI3CG, PI3K, PI3K-alpha, PI3K-beta, PI3K-delta, PI3K-gamma, PI3KC A, PI3KCB, PIK3, PIK3C A, PIK3C1, PIK3R1, PK3CA_HUMAN, PK3CB_HUMAN, PK3CD_HUMAN, PK3CG_HUMAN, Phosphatidylinositol 3 kinase catalytic alpha polypeptide, Phosphatidylinositol 3 kinase catalytic 110 KD alpha, Phosphatidylinositol 3 kinase catalytic 110 kD gamma, Phosphatidylinositol 3 kinase catalytic beta polypeptide, Phosphatidylinositol 3 kinase catalytic delta polypeptide, Phosphatidylinositol 3 kinase gamma, p110 gamma, Phosphatidylinositol 3 kinase, catalytic, gamma polypeptide, Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta, Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit gamma, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit gamma, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit gamma isoform, Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha, Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit delta, Phosphatidylinositol 4,5 bisphosphate 3 kinase, catalytic subunit delta, Phosphatidylinositol-4, Phosphoinositide 3 kinase B, Phosphoinositide 3 kinase C, Phosphoinositide 3 kinase catalytic alpha polypeptide, Phosphoinositide 3 kinase catalytic beta polypeptide, Phosphoinositide 3 kinase catalytic delta polypeptide, Phosphoinositide 3 kinase gamma catalytic subunit, Phosphoinositide 3 kinase, catalytic, delta polypeptide variant p37delta, Phosphoinositide-3-kinase catalytic gamma polypeptide, Pik3cb, Pik3cd, Pik3cg, PtdIns 3 kinase p110, PtdIns-3-kinase subunit alpha, PtdIns-3-kinase subunit beta, PtdIns-3-kinase subunit delta, PtdIns-3-kinase subunit gamma, PtdIns-3-kinase subunit p110-alpha, PtdIns-3-kinase subunit p110-beta, PtdIns-3-kinase subunit p110-delta, PtdIns-3-kinase subunit p110-gamma, RAFT1, RAPT1, RP24-311F12.2, Rapamycin and FKBP12 target 1, Rapamycin associated protein FRAP2, Rapamycin target protein, Rapamycin target protein 1, SCAN1, Serine/threonine protein kinase PIK3CA, Serine/threonine protein kinase PIK3CG, Serine/threonine-protein kinase mTOR, TYDP, TYDP1_HUMAN, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, caPI3K, dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1), erythroid derived 2, like 2, nuclear factor erythroid 2 like 2, p110 BETA, p110 alpha, p110 gamma, p110D, p110delta, p110dp85a, p120-PI3K, p85-ALPHA