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AB142171

NVP DPP 728, DPP-IV inhibitor

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(1 Publication)

MW 371.3 Da, Purity >98%. Potent, selective, reversible dipeptidyl peptidase-IV (DPP-IV) inhibitor (Ki = 11 nM). Antidiabetic agent in vivo. Orally active.
1 Images
Chemical Structure - NVP DPP 728, DPP-IV inhibitor (AB142171)
  • Chemical Structure

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Chemical Structure - NVP DPP 728, DPP-IV inhibitor (AB142171)

2D chemical structure image of ab142171, NVP DPP 728, DPP-IV inhibitor

Key facts

CAS number

207556-62-5

Purity

>98%

Form

Solid

form

Molecular weight

371.3 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>0</sub>Cl<sub>2</sub>N<sub>6</sub>O

PubChem

9799555

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

Nvp dpp 728 dihydrochloride

Biological description

Potent, selective, reversible dipeptidyl peptidase-IV (DPP-IV) inhibitor (Ki = 11 nM). Antidiabetic agent in vivo. Orally active.

Canonical smiles

C1CC(N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N.Cl.Cl

Isomeric smiles

C1C[C@H](N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N.Cl.Cl

InChi

InChI=1S/C15H18N6O.2ClH/c16-8-12-3-4-14(20-10-12)19-6-5-18-11-15(22)21-7-1-2-13(21)9-17;;/h3-4,10,13,18H,1-2,5-7,11H2,(H,19,20);2*1H/t13-;;/m0../s1

InChiKey

VNACOBVZDCLAEV-GXKRWWSZSA-N

IUPAC Name

6-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile;dihydrochloride

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1964 DPP IV Inhibitor, NVP DPP 728. 1964-5 is the same size as the 5 mg size of ab142171.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

FEBS letters 594:2840-2866 PubMed32506501

2020

A proopiomelanocortin-derived peptide sequence enhances plasma stability of peptide drugs.

Applications

Unspecified application

Species

Unspecified reactive species

Karin Löw,Alexandre Roulin,Stefan Kunz
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