NVP-TAE684, ALK inhibitor

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MW 614.2 Da, Purity >98%. Highly potent, selective ALK inhibitor in vitro (IC₅₀ = 2 nM). Suppresses lymphomagenesis in vivo. Down-regulates CD30 expression. Antitumor agent. Potent LRRK2 kinase inhibitor (IC₅₀ = 7.8 nM).

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ALK tyrosine kinase receptor, ALK/EML4 fusion gene, included, ALK/NPM1 fusion gene, included, ALK_HUMAN, Alpha-PAK, Anaplastic lymphoma kinase, Anaplastic lymphoma kinase Ki1, B55, Beta PAK, CAM kinase II delta, CAMK 2, CAMK 2B, CAMK 2d, CAMK2G, CAMKA, CD 246, CD246 antigen, CDKN1A, CaM kinase II, CaM kinase II alpha, CaM kinase II beta, CaM kinase II gamma, CaM kinase II subunit alpha, CaMK-II subunit alpha, Calcium / calmodulin dependent protein kinase II delta, Calcium/calmodulin dependent protein kinase II gamma, Calcium/calmodulin-dependent protein kinase II-alpha, Calcium/calmodulin-dependent protein kinase type II subunit alpha, Camk2a, EC 2.7.10.1, EC 2.7.11.1, GCK family kinase MiNK, GSD9C, Gamma-PAK, Germinal center kinase like kinase, Germinal center kinase-related protein kinase, KCC2A_HUMAN, KHS, KI 1, Kinase homologous to SPS1/STE20, MAP4K3, MAPK/ERK kinase kinase kinase 3, MAPK/ERK kinase kinase kinase 5, MAPK/ERK kinase kinase kinase 6, MAPKKKK3, MEK (MAP/ERK) kinase kinase 6, MEK kinase kinase 3, MEK kinase kinase 5, MEK kinase kinase 6, MEKKK 3, MEKKK 5, MEKKK6, MGC21111, MINK, MRX30, MRX47, Misshapen NIKs Related kinase, Misshapen like kinase 1, Misshapen/NIK related kinase, Mitogen activated protein kinase kinase kinase kinase 6, NBLST 3, OPHN3, Oligophrenin 3, P21 (CDKN1A) activated kinase 2, P21 (CDKN1A) activated kinase 3, P21 protein (Cdc42/Rac) activated kinase 1, P21 protein (Cdc42/Rac) activated kinase 3, P21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related), P58, PAK alpha, PAK3beta, PAK65, PAKgamma, PHK gamma LT, PHK gamma T, PSK C3, Phosphorylase b kinase gamma catalytic chain testis/liver isoform, Phosphorylase b kinase gamma catalytic chain, liver/testis isoform, Phosphorylase kinase catalytic subunit gamma 2, Phosphorylase kinase gamma subunit 2, Phosphorylase kinase subunit gamma 2, Phosphorylase kinase, gamma 2 (testis), Phosphorylase kinase, gamma 2 (testis/liver), RAB8IPL1, RP23-122P1.6, S6/H4 kinase, STE20 homolog, yeast, Serine/threonine protein kinase PAK 2, Serine/threonine protein kinase PAK 3, Serine/threonine protein kinase PHKG2, Serine/threonine-protein kinase PAK 1, TCRZ, TFG/ALK, Ysk2, ZC3, anaplastic lymphoma kinase (Ki-1), anaplastic lymphoma receptor tyrosine kinase, bPAK, calcium/calmodulin-dependent protein kinase II beta, hMINK, hPAK3, mitogen-activated protein kinase kinase kinase kinase 3, mutant anaplastic lymphoma kinase, p21 activated kinase 3, p21 protein (Cdc42/Rac)-activated kinase 2, p21-activated kinase 1, p21-activated kinase 2, p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast), p65-PAK