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AB120022

ODQ, NO-sensitive guanylyl cyclase inhibitor

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(10 Publications)

MW 187.15 Da, Purity >99%. Selective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase. Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

1,8-cineole 2-exo-monooxygenase, AAD20, AI838772, AW493413, Albendazole monooxygenase, Albendazole sulfoxidase, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, DKFZp686O15119, DNA-binding factor KBF1, FLJ10358, FLJ11090, GAC, GAM, GLS, GLS1, GLSK_HUMAN, Glucocorticoid inducible P450, Glutaminase C, Glutaminase kidney isoform, Glutaminase phosphate activated, HLP, K-glutaminase, KGA, KIAA0838, L-glutamine amidohydrolase, MGC104252, MGC112732, MGC126680, NF 25, NFKB-p105, Nifedipine oxidase, Nuclear factor NF kappa B, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, Quinine 3-monooxygenase, RP24-311F12.2, SCAN1, TYDP, TYDP1_HUMAN, Taurochenodeoxycholate 6-alpha-hydroxylase, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, mitochondrial

1 Images
Chemical Structure - ODQ, NO-sensitive guanylyl cyclase inhibitor (AB120022)
  • Chemical Structure

Lab

Chemical Structure - ODQ, NO-sensitive guanylyl cyclase inhibitor (AB120022)

2D chemical structure image of ab120022, ODQ, NO-sensitive guanylyl cyclase inhibitor

Key facts

CAS number

41443-28-1

Purity

>99%

Form

Solid

form

Molecular weight

187.15 Da

Molecular formula

C<sub>9</sub>H<sub>5</sub>N<sub>3</sub>O<sub>2</sub>

PubChem

1456

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 25 mM

Biochemical name

1h-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

Biological description

Selective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase.

Canonical smiles

C1=CC=C2C(=C1)N=CC3=NOC(=O)N23

InChi

InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H

InChiKey

LZMHWZHOZLVYDL-UHFFFAOYSA-N

IUPAC Name

[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one

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Complementary Products

Biochemicals

AB145197

DEA NONOate (Diethylamine nonoate), Nitric oxide (NO) donor

Chemical Structure - DEA NONOate (Diethylamine nonoate), Nitric oxide (NO) donor (AB145197)

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  • 0
Biochemicals

AB120423

KT5823, inhibitor of PKG

Chemical Structure - KT5823, inhibitor of PKG (AB120423)

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  • 0
Secondary Antibodies

AB205719

Goat Anti-Mouse IgG H&L (HRP)

Western blot - Goat Anti-Mouse IgG H&L (HRP) (AB205719)

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  • 4
Proteins & Peptides

AB259382

Recombinant human IL-7 protein (Active)

Premium Bioactive

Mass Spectrometry - Recombinant human IL-7 protein (Active) (AB259382)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cytochrome P450 3A4 (CYP3A4) also known as TDP1 and Glutaminase is an important enzyme involved in drug metabolism. Its molecular weight is approximately 57 kDa. This enzyme is highly expressed in the liver and small intestine playing an important role in the oxidative metabolism of a wide range of substrates including steroids and pharmaceuticals. CYP3A4 contains a heme group which is essential for its catalytic activity allowing it to add oxygen into organic substances.
Biological function summary

Cytochrome P450 3A4 facilitates the metabolism of endogenous compounds and xenobiotics. It is not part of a stable complex but often works in conjunction with NADPH-cytochrome P450 reductase to carry out its functions. This activity helps in maintaining the balance of hormones and processing compounds for elimination from the body. By metabolizing toxins CYP3A4 protects cells from damage and aids in the detoxification process.

Pathways

The enzyme plays a critical role in the drug metabolism and pharmacokinetics pathways. It interacts with the cytochrome P450 system which includes other enzymes like CYP1A2 and CYP2D6 contributing to the metabolic clearance of drugs. This pathway is essential in determining the half-life of medications within the system and impacts the efficacy and toxicity of therapeutic agents in humans.

CYP3A4 influences conditions such as cancer and liver disease. Impaired or altered CYP3A4 activity can lead to drug-induced liver injury or affect the treatment outcomes in chemotherapy where drug metabolism is vital. In liver disease such as hepatitis changes in CYP3A4 expression or function can affect drug response. It connects with proteins such as tumor suppressor protein p53 which is often modulated by enzymatic changes in cancer progression.
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Product protocols

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 11:663778 PubMed34235078

2021

PDE2 Inhibits PKA-Mediated Phosphorylation of TFAM to Promote Mitochondrial Ca-Induced Colorectal Cancer Growth.

Applications

Unspecified application

Species

Unspecified reactive species

Yilin Zhao,Yaya Wang,Jing Zhao,Zhaohui Zhang,Mingpeng Jin,Feng Zhou,Chao Jin,Jing Zhang,Jinliang Xing,Nan Wang,Xianli He,Tingting Ren

Journal of pregnancy 2019:4302309 PubMed31080672

2019

Changes in Gastric Smooth Muscle Cell Contraction during Pregnancy: Effect of Estrogen.

Applications

Unspecified application

Species

Unspecified reactive species

Othman A Al-Shboul,Hanan J Al-Rshoud,Ahmed N Al-Dwairi,Mohammad A Alqudah,Mahmoud A Alfaqih,Ayman G Mustafa,Mohammad Jaafar

Biomedical reports 9:511-516 PubMed30546879

2018

Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Othman A Al-Shboul,Ayman G Mustafa,Amal Abu Omar,Ahmed N Al-Dwairi,Mohammad A Alqudah,Mona S Nazzal,Mahmoud A Alfaqih,Rami A Al-Hader

Experimental and therapeutic medicine 16:1685-1692 PubMed30186388

2018

Estrogen relaxes gastric muscle cells via a nitric oxide- and cyclic guanosine monophosphate-dependent mechanism: A sex-associated differential effect.

Applications

Unspecified application

Species

Unspecified reactive species

Othman A Al-Shboul,Mona S Nazzal,Ayman G Mustafa,Ahmed N Al-Dwairi,Mohammad A Alqudah,Amal Abu Omar,Mahmoud A Alfaqih,Mohammad I Alsalem

Journal of neurophysiology 111:659-74 PubMed24259545

2013

Nitric oxide-mediated modulation of the murine locomotor network.

Applications

Unspecified application

Species

Unspecified reactive species

Joshua D Foster,Catherine Dunford,Keith T Sillar,Gareth B Miles

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:15675-85 PubMed24089475

2013

Non-Hebbian long-term potentiation of inhibitory synapses in the thalamus.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Rahel Sieber,Rogier Min,Thomas Nevian

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:3390-401 PubMed23426667

2013

Locus coeruleus stimulation recruits a broad cortical neuronal network and increases cortical perfusion.

Applications

Unspecified application

Species

Unspecified reactive species

Xavier Toussay,Kaustuv Basu,Baptiste Lacoste,Edith Hamel

The Journal of biological chemistry 287:20187-96 PubMed22474320

2012

Intracellular nitric oxide mediates neuroproliferative effect of neuropeptide y on postnatal hippocampal precursor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Angela Cheung,Philip L Newland,Malik Zaben,George S Attard,William P Gray

The Journal of biological chemistry 286:33190-202 PubMed21813646

2011

Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Gao Jin,Shao-Rui Chen,Xue-Hong Cao,Li Li,Hui-Lin Pan

Neuropsychopharmacology : official publication of 36:1811-22 PubMed21508928

2011

Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens.

Applications

Unspecified application

Species

Unspecified reactive species

Henrike Hartung,Sarah Threlfell,Stephanie J Cragg
View all publications
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