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AB120736

Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist

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MW 312.43 g/mol, Purity >99%. 5-HT and D2 antagonist (Ki values are 4 (5-HT2A), 11 (5-HT2C) and 57 (5-HT3), 31 (D1), 11 (D2) and 27 nM (D4)). Additionally, displays activity at: M1, M2, M3, M4, H1, α1 and α2 receptors (Ki are 1.9 at (M1), 18 (M2), 25 (M3), 13 (M4), 19 (α1) and 7 nM (α2)). Atypical antipsychotic. Displays anxiolytic activity.
2 Images
Immunocytochemistry/ Immunofluorescence - Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (AB120736)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (AB120736)

ab32572 staining β catenin in SKNSH cells treated with olanzapine (ab120736), by ICC/IF. Increase in expression of β catenin correlates with increased concentration of olanzapine, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120736 (olanzapine) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32572 (1/200 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (AB120736)
  • Chemical Structure

Lab

Chemical Structure - Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (AB120736)

2D chemical structure image of ab120736, Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist

Key facts

CAS number

132539-06-1

Purity

>99%

Form

Solid

form

Molecular weight

312.43 g/mol

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>2</sub><sub>0</sub>N<sub>4</sub>S

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

5-HT and D2 antagonist (Ki values are 4 (5-HT2A), 11 (5-HT2C) and 57 (5-HT3), 31 (D1), 11 (D2) and 27 nM (D4)). Additionally, displays activity at: M1, M2, M3, M4, H1, α1 and α2 receptors (Ki are 1.9 at (M1), 18 (M2), 25 (M3), 13 (M4), 19 (α1) and 7 nM (α2)). Atypical antipsychotic. Displays anxiolytic activity.

IUPAC Name

2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Biochemicals

AB120528

Serotonin hydrochloride (5-HT/5-Hydroxytryptamine), 5-HT receptor agonist

Chemical Structure - Serotonin hydrochloride (5-HT/5-Hydroxytryptamine), 5-HT receptor agonist (AB120528)

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Biochemicals

AB120565

Dopamine hydrochloride, Endogenous neurotransmitter

Functional Studies - Dopamine hydrochloride, Endogenous neurotransmitter (AB120565)

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Biochemicals

AB120764

Aripiprazole, Partial dopamine D2 agonist

Chemical Structure - Aripiprazole, Partial dopamine D2 agonist (AB120764)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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