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AB141066

Oleanolic acid, Natural triterpenoid

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MW 456.7 Da, Purity >96%. Natural triterpenoid. Various pharmacological attributes. Antiviral, anti-inflammatory, antiangiogenic, antiapoptotic and antitumor activities in vitro and in vivo.

View Alternative Names

70Z-SHP, ACP1, AI604853, AI838772, AW493413, Acid phosphatase 1 soluble, Acid phosphatase of erythrocyte, Adipocyte acid phosphatase, Avian reticuloendotheliosis viral (v rel) oncogene homolog A, B220, BG 37, BPTP3, CD 45, CD142, CD142 antigen, CD45 antigen, CD45R, CDC25HU2, Cdc 25B, Cdc25m2, Cell division cycle 25 homolog B, Cell division cycle 25B, Cell division cycle 25B isoform 1, Cell division cycle 25B isoform 2, Cell division cycle 25B isoform 3, Cell division cycle 25B isoform 4, Cell division cycle 25B isoform 5, Coagulation factor III, Coagulation factor III (thromboplastin tissue factor), Cytoplasmic phosphotyrosyl protein phosphatase, DNA directed DNA polymerase beta, DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit, DPOLB_HUMAN, DUS3_HUMAN, Dual specificity phosphatase 3, Dual specificity phosphatase Cdc25B, Dual specificity protein phosphatase 3, Dual specificity protein phosphatase VHR, EC 3.1.3.48, F3, FLJ11090, FLJ17960, FLJ43335, FLJ45062, FLJ45567, G protein coupled bile acid receptor BG 37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GP180, GPBAR 1, GPBAR_HUMAN, GPCR, GPCR 19, GPR 131, Group IB phospholipase A2, Group IB secretory phospholipase A2, HAAP, HCP, HCPH, HPTP1C, Hematopoietic cell phosphatase, Hematopoietic cell protein-tyrosine phosphatase, JMML, L-CA, LAR protein, LARFN5C, LARS, LCA homolog, LMW-PTP, LMW-PTPase, Leukocyte antigen related, Leukocyte antigen related (LAR) PTP receptor, Leukocyte antigen related PTP receptor, Leukocyte antigen related tyrosine phosphatase, Leukocyte common antigen, Leukocyte common antigen related, Low molecular weight cytosolic acid phosphatase, Low molecular weight phosphotyrosine protein phosphatase, Ly-5, M-BAR, M-phase inducer phosphatase 2, METCDS, MGC104252, MGC112732, MGC119834, MGC119835, MGC125976, MGC131774, MGC14433, MGC40597, MPIP2_HUMAN, Membrane bile acid receptor, Membrane-type receptor for bile acids, NF kappa B p65delta3, NFKB3, NFkB p65, Non receptor tyrosine phosphatase 1, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor kappa-B, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, OTTHUMP00000166107, OTTHUMP00000166108, OTTHUMP00000233473, OTTHUMP00000233474, OTTHUMP00000233475, OTTHUMP00000233476, OTTHUMP00000233900, PA21B_HUMAN, PAP1, PAP2, PLA 2, PLA2A, PPAC_HUMAN, PPLA 2, PTN11_HUMAN, PTN1_HUMAN, PTN2_HUMAN, PTN6_HUMAN, PTP-1B, PTP-1C, PTP-1D, PTP-2C, PTPN 1, PTPN 2, PTPN11, PTPRC_HUMAN, PTPRF protein, PTPRF_HUMAN, PTPT, PTPase, Phosphatidylcholine 2-acylhydrolase, Phosphatidylcholine 2-acylhydrolase 1B, Phospholipase A2, Phospholipase A2 group IB, Phospholipase A2 group IB (pancreas), Pol B, Pol beta, Polymerase (DNA directed) beta, Protein Tyrosine Phosphatase Receptor Type F, Protein phosphotyrosylphosphatase 1B, Protein tyrosine phosphatase, Protein tyrosine phosphatase 2, Protein tyrosine phosphatase non receptor type 1, Protein tyrosine phosphatase non receptor type 11, Protein tyrosine phosphatase non receptor type 2, Protein tyrosine phosphatase non receptor type 6, Protein tyrosine phosphatase placental, Protein tyrosine phosphatase receptor type F polypeptide, Protein tyrosine phosphatase, receptor type, C, Protein tyrosine phosphatase, receptor type, c polypeptide, Protein-tyrosine phosphatase 1B, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase 1D, Protein-tyrosine phosphatase 2C, Protein-tyrosine phosphatase SHP-1, Ptpn6, Purple acid phosphatase, RP24-311F12.2, Receptor linked protein tyrosine phosphatase LAR, Receptor type tyrosine protein phosphatase F precursor, Receptor-type tyrosine-protein phosphatase C, Receptor-type tyrosine-protein phosphatase F, Red cell acid phosphatase 1, SAP-2, SCAN1, SH-PTP1, SH-PTP2, SH-PTP3, SH2 domain containing protein tyrosine phosphatase 2, SHP 1L, SHP-2, Serine/threonine specific protein phosphatase, T-cell protein-tyrosine phosphatase, T200, T200 Glycoprotein, T200 leukocyte common antigen, TCELLPTP, TF65_HUMAN, TFA, TF_HUMAN, TGR 5, TYDP, TYDP1_HUMAN, Thromboplastin, Tissue factor, Transcription factor NFKB3, Transcription factor p65, Tyr-DNA phosphodiesterase 1, Tyrosine-protein phosphatase non-receptor type 1, Tyrosine-protein phosphatase non-receptor type 11, Tyrosine-protein phosphatase non-receptor type 2, Tyrosine-protein phosphatase non-receptor type 6, Tyrosyl-DNA phosphodiesterase 1, V rel avian reticuloendotheliosis viral oncogene homolog A, V rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B cells 3, p65, VHR, Vaccinia H1-related phosphatase, Vaccinia virus phosphatase VH1 related, hBG 37, hGPCR 19, nfkappabp65, p65, p65 NF kappaB, p65 NFkB, phosphatase, acid, of erythrocyte, relA, sPLA2IB, testicular secretory protein Li 37, v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)), v rel reticuloendotheliosis viral oncogene homolog A (avian)

1 Images
Chemical Structure - Oleanolic acid, Natural triterpenoid (AB141066)
  • Chemical Structure

Lab

Chemical Structure - Oleanolic acid, Natural triterpenoid (AB141066)

2D chemical structure image of ab141066, Oleanolic acid, Natural triterpenoid

Key facts

CAS number

508-02-1

Purity

>96%

Form

Solid

form

Source

Olea Europaea

Molecular weight

456.7 Da

Molecular formula

C<sub>3</sub><sub>0</sub>H<sub>4</sub><sub>8</sub>O<sub>3</sub>

PubChem

10494

Nature

Native

Solubility

Soluble in DMSO to 10 mM

Soluble in ethanol to 10 mM

Biochemical name

Oleanolic acid

Biological description

Natural triterpenoid. Various pharmacological attributes. Antiviral, anti-inflammatory, antiangiogenic, antiapoptotic and antitumor activities in vitro and in vivo.

Canonical smiles

CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1)C)C(=O)O)C

Isomeric smiles

C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)C)O

InChi

InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1

InChiKey

MIJYXULNPSFWEK-GTOFXWBISA-N

IUPAC Name

(4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CD45RO also known as PTPRC functions as a protein tyrosine phosphatase involved in lymphocyte signaling. This protein exists on the surface of mature T-cells and memory T-cells and has a molecular mass of approximately 200 kDa. CD45RO influences T-cell receptor signaling through dephosphorylation of specific substrates affecting the immune response. It is expressed mostly in hematopoietic cells. Additionally other targets like NF-kB p65 and DNA Polymerase beta interact with cell signaling and DNA repair processes respectively and have distinct expression and functions in different cell types. Targets like acid phosphatase (ACP1) have broader enzymatic roles impacting cellular metabolism and growth.
Biological function summary

Proteins such as CD45RO play roles in signal transduction within immune cells. This phosphatase does not function alone; it is part of larger complexes that regulate immune responses. Targets like NF-kB p65 form transcription complexes that manage inflammation and cell survival. Furthermore Acid phosphatase/ACP1 facilitates cellular phosphate metabolism supporting various cellular processes. DNA Polymerase beta functions importantly in the base excision repair complex addressing DNA damage efficiently. These targets act synergistically with natural immunomodulators to maintain cellular and systemic homeostasis.

Pathways

Proteins like CD45RO and GPCR TGR5 participate in the immune and metabolic signaling pathways. CD45RO influences pathways involving kinases such as Lck and Fyn which are critical to T-cell receptor mediated signal transduction. In parallel GPCR TGR5 modulates metabolic pathways influencing energy expenditure and bile acid signaling. The nuclear factor NF-kB p65 is a significant player in pathways controlling immune and inflammatory responses interacting with ather at a molecular level. Proper regulation of these pathways ensures balanced cellular physiology and immune responses.

Proteins such as CD45RO and NF-kB p65 have implications in conditions like autoimmune disorders and cancer. Aberrant CD45RO expression or function associates with autoimmune diseases such as rheumatoid arthritis where it interacts abnormally with other phosphatases like SHP1 and SHP2. Meanwhile NF-kB p65's dysregulation relates to cancer development as it affects the transcriptional response to inflammatory signals involving partners like DNA Polymerase beta. These connections highlight the importance of these targets in disease mechanisms and potential therapeutic strategies.

Product protocols

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