JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141829

Oligomycin, ATP synthase inhibitor

Be the first to review this product! Submit a review

|

(26 Publications)

MW 791.06 Da, Purity >95%. ATP synthase inhibitor. Blocks the proton channel (Fo subunit). Macrolide antibiotic.
2 Images
Functional Studies - Oligomycin, ATP synthase inhibitor (AB141829)
  • FuncS

Unknown

Functional Studies - Oligomycin, ATP synthase inhibitor (AB141829)

Oligomycin inhibits ATP-dependent adipogenesis in 3T3-L1 cells. Cells were induced to undergo adipocyte differentiation (A-D) for 5 days. Different concentrations of Oligomycin (ab141829) were then added (B, 1 µg/ml; C, 2 µg/ml and D, 10 µg/ml). After 10 days, the cells were stained with Oil Red O and visualized under light microscopy.

Chemical Structure - Oligomycin, ATP synthase inhibitor (AB141829)
  • Chemical Structure

Lab

Chemical Structure - Oligomycin, ATP synthase inhibitor (AB141829)

2D chemical structure image of ab141829, Oligomycin, ATP synthase inhibitor

Key facts

CAS number

1404-19-9

Purity

>95%

Form

Solid

form

Molecular weight

791.06 Da

Molecular formula

C<sub>4</sub><sub>5</sub>H<sub>7</sub><sub>4</sub>O<sub>1</sub><sub>1</sub> (for Oligomycin A)

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 100 mM

Biological description

ATP synthase inhibitor. Blocks the proton channel (Fo subunit). Macrolide antibiotic.

style
left-column

Complementary Products

Biochemicals

AB120081

FCCP, mitochondrial oxidative phosphorylation uncoupler

Chemical Structure - FCCP, mitochondrial oxidative phosphorylation uncoupler (AB120081)

  • 4
  • 1
Biochemicals

AB143145

Rotenone, mitochondrial electron transport chain inhibitor

Chemical Structure - Rotenone, mitochondrial electron transport chain inhibitor (AB143145)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Atad5 also known as ELG1 or PCNA unloader is a protein involved in DNA replication and repair. Atad5 has a molecular mass of approximately 215 kDa. You can find Atad5 mainly in the nucleus where DNA replication and repair processes occur. It is expressed in different tissues showing its widespread importance in cellular functions. The protein consists of several domains important for binding other proteins important for its function in maintaining genome stability.
Biological function summary

Atad5 plays an important role in the regulation of replication fork stability and the unloading of PCNA (Proliferating Cell Nuclear Antigen) from DNA. It works as a part of a larger complex involved in DNA replication stress response. Atad5 coordinates protein biosynthesis pathways and ensures the proper completion of the DNA replication process. Oligomyosin domains in Atad5 assist in interacting with other proteins allowing it to perform its functions effectively within the cell's nuclear machinery.

Pathways

Atad5 operates in the DNA damage response and repair processes. It orchestrates the unloading of PCNA from chromatin which is important for DNA synthesis replication fork restart and repair. Atad5 associates with other proteins like RAD17 during these processes ensuring accurate DNA replication and maintaining genomic integrity. Atad5 also affects the ATR-Chk1 signaling pathway reflecting its significant role in cellular stress responses.

Atad5 is linked to chromosomal instability and cancer. Mutations or dysfunctions in Atad5 can lead to uncontrolled or faulty DNA replication contributing to tumorigenesis. Atad5 interacts with proteins such as CHK1 in response to DNA damage and its mutation can disrupt this interaction possibly leading to cancerous growth. Additionally altered Atad5 function is associated with DNA repair disorders leading to heightened sensitivity to DNA-damaging agents and increased risk of disease.
style
left-column
style
left-column

Product protocols

style
left-column

Publications (26)

Recent publications for all applications. Explore the full list and refine your search

PLoS biology 22:e3002941 PubMed39680501

2024

SLMO transfers phosphatidylserine between the outer and inner mitochondrial membrane in Drosophila.

Applications

Unspecified application

Species

Unspecified reactive species

Siwen Zhao,Xuguang Jiang,Ning Li,Tao Wang

Life science alliance 8: PubMed39658088

2024

Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Émilie Lavallée,Maëline Roulet-Matton,Viviane Giang,Roxana Cardona Hurtado,Dominic Chaput,Simon-Pierre Gravel

Journal of nanobiotechnology 22:540 PubMed39237942

2024

Enhanced osteogenic differentiation in 3D hydrogel scaffold via macrophage mitochondrial transfer.

Applications

Unspecified application

Species

Unspecified reactive species

Shui Qiu,Lili Cao,Dingding Xiang,Shu Wang,Di Wang,Yiyi Qian,Xiaohua Li,Xiaoshu Zhou

Scientific reports 14:19862 PubMed39191795

2024

Tensin-2 interactomics reveals interaction with GAPDH and a phosphorylation-mediated regulatory role in glycolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Paula Turkki,Iftekhar Chowdhury,Tiina Öhman,Latifeh Azizi,Markku Varjosalo,Vesa P Hytönen

Journal of animal science and biotechnology 15:108 PubMed39113148

2024

Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Wang,Jianfei Gong,Nuo Heng,Yingfan Hu,Rui Wang,Huan Wang,Wei He,Ni Zhu,Zhihui Hu,Haisheng Hao,Huabin Zhu,Shanjiang Zhao

Cell communication and signaling : CCS 22:283 PubMed38783346

2024

APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition.

Applications

Unspecified application

Species

Unspecified reactive species

Huihui Zhao,Xinxin Cheng,Liping Yan,Fang Mi,Wenqing Wang,Yuying Hu,Xingyang Liu,Yuyan Fan,Qingjie Min,Yan Wang,Weimin Zhang,Qingnan Wu,Qimin Zhan

Cell reports 43:114237 PubMed38753484

2024

Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Tang,Junru Wu,Xuejing Sun,Shasha Tan,Wenbo Li,Siyu Yin,Lun Liu,Yuanyuan Chen,Yuanyuan Liu,Qian Tan,Youxiang Jiang,Wenjing Yang,Wei Huang,Chunyan Weng,Qing Wu,Yao Lu,Hong Yuan,Qingzhong Xiao,Alex F Chen,Qingbo Xu,Timothy R Billiar,Jingjing Cai

Traffic (Copenhagen, Denmark) 25:e12933 PubMed38600522

2024

ATG7(2) Interacts With Metabolic Proteins and Regulates Central Energy Metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Kevin Ostacolo,Adrián López García de Lomana,Clémence Larat,Valgerdur Hjaltalin,Kristrun Yr Holm,Sigríður S Hlynsdóttir,Margaret Soucheray,Linda Sooman,Ottar Rolfsson,Nevan J Krogan,Eirikur Steingrimsson,Danielle L Swaney,Margret H Ogmundsdottir

Cell communication and signaling : CCS 22:210 PubMed38566195

2024

Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiyong Zhang,Pengfei Li,Ying Chen,Yuxi Chen,Xiuzhu Wang,Sunan Shen,Yue Zhao,Yanan Zhu,Tingting Wang

Bioactive materials 35:549-563 PubMed38434800

2024

Extracellular matrix stiffness as an energy metabolism regulator drives osteogenic differentiation in mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Na,Zhijie Yang,Qiusheng Shi,Chiyu Li,Yu Liu,Yaxin Song,Xinyang Li,Lisha Zheng,Yubo Fan
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com