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MW 791.06 Da, Purity >95%. ATP synthase inhibitor. Blocks the proton channel (Fo subunit). Macrolide antibiotic.

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Images

Chemical Structure - Oligomycin, ATP synthase inhibitor (AB141829), expandable thumbnail
  • Functional Studies - Oligomycin, ATP synthase inhibitor (AB141829), expandable thumbnail

Publications

Key facts

CAS number

1404-19-9

Purity

> 95%

Form

Solid

Molecular weight

791.06 Da

Molecular formula

C45H74O11forOligomycinA

Nature

Synthetic

Recommended products

MW 791.06 Da, Purity >95%. ATP synthase inhibitor. Blocks the proton channel (Fo subunit). Macrolide antibiotic.

Key facts

Purity

> 95%

Solubility

Soluble in ethanol to 10 mM. Soluble in DMSO to 100 mM.

Biological description

ATP synthase inhibitor. Blocks the proton channel (Fo subunit). Macrolide antibiotic.

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Atad5 also known as ELG1 or PCNA unloader is a protein involved in DNA replication and repair. Atad5 has a molecular mass of approximately 215 kDa. You can find Atad5 mainly in the nucleus where DNA replication and repair processes occur. It is expressed in different tissues showing its widespread importance in cellular functions. The protein consists of several domains important for binding other proteins important for its function in maintaining genome stability.

Biological function summary

Atad5 plays an important role in the regulation of replication fork stability and the unloading of PCNA (Proliferating Cell Nuclear Antigen) from DNA. It works as a part of a larger complex involved in DNA replication stress response. Atad5 coordinates protein biosynthesis pathways and ensures the proper completion of the DNA replication process. Oligomyosin domains in Atad5 assist in interacting with other proteins allowing it to perform its functions effectively within the cell's nuclear machinery.

Pathways

Atad5 operates in the DNA damage response and repair processes. It orchestrates the unloading of PCNA from chromatin which is important for DNA synthesis replication fork restart and repair. Atad5 associates with other proteins like RAD17 during these processes ensuring accurate DNA replication and maintaining genomic integrity. Atad5 also affects the ATR-Chk1 signaling pathway reflecting its significant role in cellular stress responses.

Associated diseases and disorders

Atad5 is linked to chromosomal instability and cancer. Mutations or dysfunctions in Atad5 can lead to uncontrolled or faulty DNA replication contributing to tumorigenesis. Atad5 interacts with proteins such as CHK1 in response to DNA damage and its mutation can disrupt this interaction possibly leading to cancerous growth. Additionally altered Atad5 function is associated with DNA repair disorders leading to heightened sensitivity to DNA-damaging agents and increased risk of disease.

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2 product images

  • Chemical Structure - Oligomycin, ATP synthase inhibitor (ab141829), expandable thumbnail

    Chemical Structure - Oligomycin, ATP synthase inhibitor (ab141829)

    2D chemical structure image of ab141829, Oligomycin, ATP synthase inhibitor

  • Functional Studies - Oligomycin, ATP synthase inhibitor (ab141829), expandable thumbnail

    Functional Studies - Oligomycin, ATP synthase inhibitor (ab141829)

    Oligomycin inhibits ATP-dependent adipogenesis in 3T3-L1 cells. Cells were induced to undergo adipocyte differentiation (A-D) for 5 days. Different concentrations of Oligomycin (ab141829) were then added (B, 1 µg/ml; C, 2 µg/ml and D, 10 µg/ml). After 10 days, the cells were stained with Oil Red O and visualized under light microscopy.

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