Olomoucine II, CDK/cyclin inhibitor

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MW 370.4 Da, Purity >98%. CDK/cyclin inhibitor (IC₅₀ values are 7.6 (CDK1/cyclin B), 0.1 (CDK2/cyclin E), 19.8 (CDK4/cyclin D1), 0.45 (CDK7/cyclin H) and 0.06 (CDK9/cyclin T) μM). Shows an IC₅₀ of >100 μM for 10 other kinases. Antiproliferative and anticancer activity in vitro.

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39 kDa protein kinase, 6430598J10Rik, CAK, CAK 1, CCNB, CCNB1_HUMAN, CCNB2_HUMAN, CCNE, CCNE1_HUMAN, CCNT, CCNT1_HUMAN, CD5R1_HUMAN, CDC2-related protein kinase 6, CDC28A, CDK-activating kinase, CDK-activating kinase 1, CDK11, CDK14_HUMAN, CDK16_HUMAN, CDK17_HUMAN, CDK18_HUMAN, CDK19_HUMAN, CDK1_HUMAN, CDK5 activator 1, CDK5P35, CDK5R, CDK5R1, CDK6_HUMAN, CDK7_HUMAN, CDK8 like cyclin dependent kinase, CDK8 protein kinase, CDK8_HUMAN, CDK9 associated C type protein, CDKN1, CDKN2, CDKN5, CDKN7, CELL CYCLE CONTROLLER CDC2, Cdc 2, Cell Division Kinase 8, Cell Divsion Cycle 2 Protein, Cell division control protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2 to M, Cell division cycle 2 like 6 (CDK8 like), Cell division cycle 2-like protein kinase 6, Cell division protein kinase 1, Cell division protein kinase 14, Cell division protein kinase 16, Cell division protein kinase 17, Cell division protein kinase 18, Cell division protein kinase 19, Cell division protein kinase 2, Cell division protein kinase 3, Cell division protein kinase 4, Cell division protein kinase 5, Cell division protein kinase 6, Cell division protein kinase 7, Cell division protein kinase 8, Cell division protein kinase 9, Crk 2, Cyc T1, CycB2, Cyclin B1, Cyclin B2, Cyclin C related protein, Cyclin E1, Cyclin Es, Cyclin Et, Cyclin T1b, Cyclin dependent kinase (CDC2 like) 11, Cyclin dependent kinase 19 variant 2, Cyclin-T, Cyclin-T1, Cyclin-dependent kinase 1, Cyclin-dependent kinase 11, Cyclin-dependent kinase 14, Cyclin-dependent kinase 16, Cyclin-dependent kinase 17, Cyclin-dependent kinase 18, Cyclin-dependent kinase 19, Cyclin-dependent kinase 2, Cyclin-dependent kinase 3, Cyclin-dependent kinase 4, Cyclin-dependent kinase 5, Cyclin-dependent kinase 5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, Cyclin-dependent kinase 6, Cyclin-dependent kinase 7, Cyclin-dependent kinase 8, Cyclin-dependent kinase 9, Cyclin-dependent-like kinase 5, CyclinE, DKFZp686L20222, Death-preventing kinase, EC 2.7.1.37, G1/S specific cyclin E, G1/S-specific cyclin-E1, G2 mitotic specific cyclin B1, G2 mitotic specific cyclin B2, G2/mitotic specific cyclin B3, G2/mitotic-specific cyclin-B1, G2/mitotic-specific cyclin-B2, HCAK, HIVE1, Homolog of Xenopus MO15 Cdk activating kinase, HsT17299, Human immunodeficiency virus 1 expression, Human immunodeficiency virus type 1 (HIV 1) expression (elevated) 1, K35, KIAA0834, KIAA1028, Kinase subunit of CAK, LIS7, MCPH12, MGC108931, MGC111195, MGC140694, MGC25109, MGC59692, MO15, MO15, Xenopus, homolog of, Mediator complex subunit cdk8, Mediator of RNA polymerase II transcription subunit cdk8, NCK 5A, Neuronal CDK5 activator, P23, P34CDC2, P35, P39 Mo15, PCTAIRE, PCTAIRE 3, PCTAIRE protein kinase 1, PCTAIRE protein kinase 3, PCTAIRE-motif protein kinase 1, PCTAIRE-motif protein kinase 2, PCTAIRE-motif protein kinase 3, PCTGAIRE, PCTK 3, PCTK1, PCTK2, PFTAIRE protein kinase 1, PFTAIRE1, PFTK1, PLSTIRE, PSSALRE, Protein kinase K35, Protein kinase cdc2-related PCTAIRE-2, RP11 805H4.3, Regulatory partner for CDK5 kinase, STK-1, STQTL11, Serine threonine kinase Stk1, Serine/threonine protein kinase 1, Serine/threonine protein kinase MO15, Serine/threonine-protein kinase PCTAIRE-1, Serine/threonine-protein kinase PCTAIRE-2, Serine/threonine-protein kinase PCTAIRE-3, Serine/threonine-protein kinase PFTAIRE-1, Serine/threonine-protein kinase PLSTIRE, Serine/threonine-protein kinase PSSALRE, Subunit of positive elongation transcription factor b, TFIIH basal transcription factor complex kinase subunit, TPKII catalytic subunit, TPKII regulatory subunit, Tau protein kinase II 23 kDa subunit, Tau protein kinase II catalytic subunit, bA346C16.3, cyclin E variant ex5del, cyclin E variant ex7del, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase), hPFTAIRE1, mKIAA0834, p25, p33 protein kinase, p33(CDK2), p34 Cdk1, p34 protein kinase, pTEFb subunit