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AB144849

OM173-alphaA, DNMT3B and FTase inhibitor

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MW 316.3 Da, Purity >95%. Potent, selective DNA (cytosine-5)-methyltransferase 3B (DNMT3B) inhibitor (IC50 = 500nM). Farnesyltransferase (FTase) inhibitor (IC50 = 3.2μM). Antibiotic and antimycoplasmal agent. Nanaomycin A methyl ester.
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Chemical Structure - OM173-alphaA, DNMT3B and FTase inhibitor (AB144849)
  • Chemical Structure

Lab

Chemical Structure - OM173-alphaA, DNMT3B and FTase inhibitor (AB144849)

2D chemical structure image of ab144849, OM173-alphaA, DNMT3B and FTase inhibitor

Key facts

CAS number

58286-56-9

Purity

>95%

Form

Solid

form

Source

Streptomyces sp.

Molecular weight

316.3 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>6</sub>O<sub>6</sub>

PubChem

12803368

Nature

Native

Solubility

Soluble in DMSO

Soluble in ethanol

Biochemical name

OM173-alphaA

Biological description

Potent, selective DNA (cytosine-5)-methyltransferase 3B (DNMT3B) inhibitor (IC50 = 500nM). Farnesyltransferase (FTase) inhibitor (IC50 = 3.2μM). Antibiotic and antimycoplasmal agent. Nanaomycin A methyl ester.

Canonical smiles

CC1C2=C(CC(O1)CC(=O)OC)C(=O)C3=C(C2=O)C(=CC=C3)O

Isomeric smiles

C[C@H]1C2=C(C[C@@H](O1)CC(=O)OC)C(=O)C3=C(C2=O)C(=CC=C3)O

InChi

InChI=1S/C17H16O6/c1-8-14-11(6-9(23-8)7-13(19)22-2)16(20)10-4-3-5-12(18)15(10)17(14)21/h3-5,8-9,18H,6-7H2,1-2H3/t8-,9+/m0/s1

InChiKey

FMEUWIKCSICJBO-DTWKUNHWSA-N

IUPAC Name

methyl 2-[(1S,3R)-9-hydroxy-1-methyl-5,10-dioxo-3,4-dihydro-1H-benzo[g]isochromen-3-yl]acetate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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