AB120210

omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type)

Name: omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (CAS 145017-83-0) | Abcam
Brand: Abcam Limited
SKU: AB120210
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(8 Publications)

MW 5202 Da. Achieve your results faster with highly validated, pure and trusted compounds.

2 Images

Functional Studies - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

FuncS

PubMed

Functional Studies - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

Many VGCC subtypes contribute to calcium signalling in ganglion cell bodies.

Summary of Ca²⁺ imaging results in RGC somata showing the following changes in paired pulse Ca²⁺ signal in response to drugs (applied during the second K⁺ pulse) compared to their control paired K⁺ pulses (K) : 10 μM nifedipine (29%±7%; p = 0.0003; n = 20), 100 μM verapamil (VPM; 39%±5%; p<0.0001; n = 17), 400 nM ω-agatoxin IVA (AGT; 35%±14%; p = 0.0364; n = 9), 3 μM ω-conotoxin-GVIA (CTX; 23%±10%; p = 0.0423; n = 15), 3 μM mibefradil (MIB; 21%±6%; p = 0.0011; n = 16) and 200 nM TTX (40%±9%; p = 0.0004; n = 14).

(From Figure 7C of Sargoy et al).

Sargoy et al PLoS One. 2014; 9(1): e84507. Reproduced under the Creative Commons license https://creativecommons.org/publicdomain/zero/1.0/

Chemical Structure - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

Chemical Structure

Lab

Chemical Structure - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

2D chemical structure image of ab120210, omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type)

Key facts

CAS number

145017-83-0

Form

Solid

form

Molecular weight

5202 Da

Molecular formula

C217H360N68O60S10

PubChem

56841669

Nature

Synthetic

Solubility

Soluble in water to 1mg/ml

Biochemical name

omega-Agatoxin IVA

Canonical smiles

CCC(C)C1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(CSSCC3C(=O)NC4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(NC4=O)CCCNC(=N)N)CCCNC(=N)N)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N5CCCC5C(=O)N3)C(C)

Isomeric smiles

CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H]3C(=O)N[C@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC4=O)CCCNC(=N)N)CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N5CCC[C@H]5C(=O)N3)[C@@H](C)O)CC6=CNC7=CC=CC=C76)CCCCN)CCCNC(=N)N)CC8=CC=C(C=C8)O)CC(=O)O)CCCCN)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N)C(=O)N[C@@H](CCCCN)C(=O)N9CCC[C@H]9C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)[C@@H](C)CC)CCSC)[C@@H](C)O)CC(=O)N

InChi

InChI=1S/C217H360N68O60S10/c1-21-111(11)168-206(337)247-115(15)174(305)254-128(48-28-34-70-219)185(316)268-144(89-167(303)304)193(324)266-141(86-119-59-61-121(289)62-60-119)181(312)246-94-159(293)250-127(55-41-77-236-216(230)231)183(314)271-147-101-349-348-100-146-202(333)283-171(114(14)24-4)209(340)277-152-106-354-350-102-148(274-192(323)143(88-156(225)290)269-210(341)172(117(17)287)278-164(298)98-244-179(310)135(67-81-346-19)262-207(338)170(113(13)23-3)281-195(326)145(99-286)270-200(152)331)198(329)260-134(64-66-166(301)302)189(320)272-150(199(330)264-137(52-32-38-74-223)211(342)284-79-43-57-154(284)204(335)261-132(56-42-78-237-217(232)233)187(318)265-140(85-110(9)10)194(325)280-169(112(12)22-2)208(339)263-136(68-82-347-20)190(321)259-133(63-65-165(299)300)178(309)243-95-160(294)251-138(83-108(5)6)180(311)245-96-161(295)252-139(84-109(7)8)191(322)248-116(16)213(344)345)104-352-353-105-151(276-205(336)155-58-44-80-285(155)212(343)173(118(18)288)279-163(297)92-239-157(291)91-240-182(313)142(87-120-90-238-124-47-26-25-45-122(120)124)267-186(317)130(258-197(147)328)50-30-36-72-221)201(332)275-149(196(327)256-126(54-40-76-235-215(228)229)177(308)242-93-158(292)249-125(53-39-75-234-214(226)227)176(307)241-97-162(296)253-146)103-351-355-107-153(203(334)282-168)273-188(319)131(51-31-37-73-222)257-184(315)129(49-29-35-71-220)255-175(306)123(224)46-27-33-69-218/h25-26,45,47,59-62,90,108-118,123,125-155,168-173,238,286-289H,21-24,27-44,46,48-58,63-89,91-107,218-224H2,1-20H3,(H2,225,290)(H,239,291)(H,240,313)(H,241,307)(H,242,308)(H,243,309)(H,244,310)(H,245,311)(H,246,312)(H,247,337)(H,248,322)(H,249,292)(H,250,293)(H,251,294)(H,252,295)(H,253,296)(H,254,305)(H,255,306)(H,256,327)(H,257,315)(H,258,328)(H,259,321)(H,260,329)(H,261,335)(H,262,338)(H,263,339)(H,264,330)(H,265,318)(H,266,324)(H,267,317)(H,268,316)(H,269,341)(H,270,331)(H,271,314)(H,272,320)(H,273,319)(H,274,323)(H,275,332)(H,276,336)(H,277,340)(H,278,298)(H,279,297)(H,280,325)(H,281,326)(H,282,334)(H,283,333)(H,299,300)(H,301,302)(H,303,304)(H,344,345)(H4,226,227,234)(H4,228,229,235)(H4,230,231,236)(H4,232,233,237)/t111-,112-,113-,114-,115-,116-,117+,118+,123-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,168-,169-,170-,171-,172-,173-/m0/s1

InChiKey

NVVFOMZVLALQKT-JYRRICCISA-N

IUPAC Name

(4S)-4-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(1R,1aS,4S,7R,10S,13S,16S,22S,25S,28R,31S,34R,39R,42S,48S,57S,60S,63R,66S,72S,75S,78S,81S,84S,87R,92R,95S)-87-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-60,78-bis(4-aminobutyl)-25-(2-amino-2-oxoethyl)-4,13,84-tris[(2S)-butan-2-yl]-1a,66,95-tris(3-carbamimidamidopropyl)-31-(2-carboxyethyl)-75-(carboxymethyl)-22,48-bis[(1R)-1-hydroxyethyl]-10-(hydroxymethyl)-72-[(4-hydroxyphenyl)methyl]-57-(1H-indol-3-ylmethyl)-81-methyl-16-(2-methylsulfanylethyl)-2,2a,5,5a,8,11,12a,14,17,20,23,26,29,32,41,47,50,53,56,59,62,65,68,71,74,77,80,83,86,93,96,99-dotriacontaoxo-8a,9a,14a,15a,36,37,89,90-octathia-a,3,3a,6,6a,9,11a,12,15,18,21,24,27,30,33,40,46,49,52,55,58,61,64,67,70,73,76,79,82,85,94,97-dotriacontazapentacyclo[61.43.4.47,28.239,92.042,46]hexadecahectane-34-carbonyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[2-[[(2S)-1-[[2-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-5-oxopentanoic acid

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (8)

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NPJ Parkinson's disease 9:4 PubMed36646701

2023

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.

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Unspecified reactive species

Nagendran Ramalingam,Shan-Xue Jin,Tim E Moors,Luis Fonseca-Ornelas,Kazuma Shimanaka,Shi Lei,Hugh P Cam,Aurelia Hays Watson,Lisa Brontesi,Lai Ding,Dinc Yasat Hacibaloglu,Haiyang Jiang,Se Joon Choi,Ellen Kanter,Lei Liu,Tim Bartels,Silke Nuber,David Sulzer,Eugene V Mosharov,Weisheng V Chen,Shaomin Li,Dennis J Selkoe,Ulf Dettmer

Frontiers in oncology 12:978755 PubMed36091107

2022

Exosomal MiR-4261 mediates calcium overload in RBCs by downregulating the expression of ATP2B4 in multiple myeloma.

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Unspecified application

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Unspecified reactive species

Sicheng Bian,Xialin Zhang,Leilei Lin,Lili Sun,Zhibo Guo,Jie Pan,Jiangxia Cui,Hanbing Yao,Jing Xu,Zhuanghui Hao,Yuzhu Wang,Liguo Tong,Xingpeng Bu,Desheng Kong,Nianjiao Liu,Yinghua Li

Molecular biology of the cell 27:3329-3341 PubMed27605709

2016

Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters.

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Unspecified reactive species

Trine Lisberg Toft-Bertelsen,Iwona Ziomkiewicz,Sébastien Houy,Paulo S Pinheiro,Jakob B Sørensen

The Journal of neuroscience : the official journal of the Society for Neuroscience 36:7184-97 PubMed27383593

2016

M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina.

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Unspecified application

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Unspecified reactive species

Cameron L Prigge,Po-Ting Yeh,Nan-Fu Liou,Chi-Chan Lee,Shih-Feng You,Lei-Lei Liu,David S McNeill,Kylie S Chew,Samer Hattar,Shih-Kuo Chen,Dao-Qi Zhang

PloS one 9:e84507 PubMed24416240

2014

Differential calcium signaling mediated by voltage-gated calcium channels in rat retinal ganglion cells and their unmyelinated axons.

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Unspecified application

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Unspecified reactive species

Allison Sargoy,Xiaoping Sun,Steven Barnes,Nicholas C Brecha

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:18951-65 PubMed24285900

2013

Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor.

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Unspecified reactive species

Bruno Vilar,Jérôme Busserolles,Bing Ling,Sophie Laffray,Lauriane Ulmann,Fanny Malhaire,Eric Chapuy,Youssef Aissouni,Monique Etienne,Emmanuel Bourinet,Francine Acher,Jean-Philippe Pin,Alain Eschalier,Cyril Goudet

PloS one 7:e32256 PubMed22389692

2012

Nitric oxide signalling augments neuronal voltage-gated L-type (Ca(v)1) and P/q-type (Ca(v)2.1) channels in the mouse medial nucleus of the trapezoid body.

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Unspecified application

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Unspecified reactive species

Adam J B Tozer,Ian D Forsythe,Joern R Steinert

Journal of psychopharmacology (Oxford, England) 26:56-70 PubMed21890595

2011

Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation.

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Unspecified application

Species

Unspecified reactive species

Meina Wang,Matthew N Hill,Longhua Zhang,Boris B Gorzalka,Cecilia J Hillard,Bradley E Alger

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omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type)

Functional Studies - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

Chemical Structure - omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (AB120210)

Key facts

CAS number

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Canonical smiles

Isomeric smiles

InChi

InChiKey

IUPAC Name

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Properties and storage information

Shipped at conditions

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Storage information

Product protocols

Publications (8)

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