ONC212

Key facts

CAS number

1807861-48-8

Purity

99%

Form

Solid

form

Molecular weight

440.5 Da

Molecular formula

C₂₄H₂₃F₃N₄O

PubChem

124085867

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM (need ultrasonication)

Biochemical name

2,4,6,7,8,9-Hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one

Biological description

ONC212 is a fluorinated imipridone analogue of ONC201. It is an activator of GPCR GPR132 and Gαq signaling, which functions as a tumor suppressor. It induces apoptosis in HPAF-II and AsPC1 cell lines at 20 μM and potently prevents colony formation at 5 μM in HPAF-II cells. It inhibits acute myeloid leukemia growth in vivo and improves overall survival in xenografted mice.

Canonical smiles

C1CN(CC2=C1N3CCN=C3N(C2=O)CC4=CC=C(C=C4)C(F)(F)F)CC5=CC=CC=C5

InChi

InChI=1S/C24H23F3N4O/c25-24(26,27)19-8-6-18(7-9-19)15-31-22(32)20-16-29(14-17-4-2-1-3-5-17)12-10-21(20)30-13-11-28-23(30)31/h1-9H,10-16H2

InChiKey

DFULPGUTXZTYKA-UHFFFAOYSA-N

IUPAC Name

11-benzyl-7-[[4-(trifluoromethyl)phenyl]methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one