MW 293.4 Da, Purity >98%. Highly potent and selective 5-HT3 antagonist. Potent antiemetic *in vivo*. Achieve your results faster with highly validated, pure and trusted compounds.
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1,8-cineole 2-exo-monooxygenase, 5 HT 2B receptor, 5 HT receptor, 5 HT(2B), 5 HT1DB, 5 HT2 receptor, 5 HT3 receptor, 5 HT3A receptor, 5 HT3RA, 5 HTR3B, 5 Hydroxytryptamine 2C receptor, 5 Hydroxytryptamine Serotonin Receptor 3a, 5 hydroxytryptamine (serotonin) receptor 1B, 5 hydroxytryptamine (serotonin) receptor 1D G protein coupled, 5 hydroxytryptamine (serotonin) receptor 2B, 5 hydroxytryptamine (serotonin) receptor 2B G protein coupled, 5 hydroxytryptamine (serotonin) receptor 3, family member C, 5 hydroxytryptamine (serotonin) receptor 3A, 5 hydroxytryptamine (serotonin) receptor 3C ionotropic, 5 hydroxytryptamine (serotonin) receptor 4, G protein coupled, 5 hydroxytryptamine 1B receptor (5 HT 1B) (Serotonin receptor) (5 HT 1D beta) (Serotonin 1D beta receptor) (S12), 5 hydroxytryptamine 2B receptor, 5 hydroxytryptamine 3 receptor, 5 hydroxytryptamine 3 receptor B subunit, 5 hydroxytryptamine 4 receptor, 5 hydroxytryptamine receptor 3 subunit C, 5 hydroxytryptamine receptor 3C, 5 hydroxytryptamine receptor 4, 5 hydroxytryptamine serotonin receptor 3B, 5 hydroxytryptamine serotonin receptor 4, 5-HT-1C, 5-HT-1D-alpha, 5-HT-1D-beta, 5-HT-2, 5-HT-3, 5-HT-4, 5-HT3 receptor subunit E splice variant HTR3Ea, 5-HT3E, 5-HT3R, 5-HT3c1, 5-HTR2C, 5-ht-1c receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine (serotonin) receptor 3 family member E, 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1C, 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 3, 5-hydroxytryptamine receptor 3 subunit E, 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine receptor 3B, 5-hydroxytryptamine receptor 3E, 5H4, 5HT1B_HUMAN, 5HT1D_HUMAN, 5HT2A_HUMAN, 5HT2B_HUMAN, 5HT2C_HUMAN, 5HT2F, 5HT3 serotonin receptor, 5HT3A_HUMAN, 5HT3B_HUMAN, 5HT3E, 5ht4 receptor, ACEE, ACES_HUMAN, AChR, ARACHE, AW061132, Acetylcholinesterase, Albendazole monooxygenase, Albendazole sulfoxidase, Apoptosis related acetylcholinesterase, B230208N19Rik, CAE 2, CCK B, CCK-B receptor, CCK-BR, CCK2 receptor, CCK2-R, CCKR Type B, CCKRB, CHRM1, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cardiac 5 HT4 receptor, Cholecystokinin B receptor, Cholecystokinin-2 receptor, Cholinergic receptor muscarinic 1, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, ECA 2, ECA4, ECA5, EIEE19, EJM, EJM5, Eag-related protein 1, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, FLJ10847, GAA 5, GABA, GABA A, GABA A Receptor alpha 3, GABA A Receptor alpha 6 polypeptide, GABA A receptor alpha 6, GABA A receptor subunit alpha 6, GABA alpha receptor beta-2 subunit, GABA subunit A receptor alpha 6, GABA(A) receptor, GABA(A) receptor beta 1, GABA(A) receptor beta 2, GABA(A) receptor gamma 2, GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-3, GABA(A) receptor subunit alpha-4, GABA(A) receptor subunit alpha-5, GABA(A) receptor subunit alpha-6, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit beta-2, GABA(A) receptor subunit beta-3, GABA(A) receptor subunit delta, GABA(A) receptor subunit gamma-1, GABA(A) receptor subunit gamma-2, GABA(A) receptor subunit gamma-3, GABA(A) receptor subunit pi, GABA(A) receptor, alpha 1, GABA-A receptor, beta-1 polypeptide, GABA-A receptor, beta-2 polypeptide, GABAA receptor beta 3 subunit, GABAA receptor subunit beta 3, GABR A3, GABR B3, GABR G3, GABRA 1, GABRA 5, GABRA 6, GABRB2, GABRG 1, GABRG 2, GABRP, GARB1, GASR_HUMAN, GBRA1_HUMAN, GBRA3_HUMAN, GBRA4_HUMAN, GBRA5_HUMAN, GBRA6_HUMAN, GBRB1_HUMAN, GBRB2_HUMAN, GBRB3_HUMAN, GBRD_HUMAN, GBRG1_HUMAN, GBRG2_HUMAN, GBRG3_HUMAN, GBRP_HUMAN, GC138184, GEFSP 3, Gaba receptor alpha 1 polypeptide, GabaA/BZ, Gamma Aminobutyric Acid A Receptor Beta 1, Gamma Aminobutyric Acid Receptor , beta-1, Gamma aminobutyric acid (GABA A) receptor subunit gamma 1, Gamma aminobutyric acid (GABA) A receptor alpha 1, Gamma aminobutyric acid (GABA) A receptor alpha 3, Gamma aminobutyric acid (GABA) A receptor alpha 4, Gamma aminobutyric acid (GABA) A receptor beta 1, Gamma aminobutyric acid (GABA) A receptor beta 3, Gamma aminobutyric acid (GABA) A receptor gamma 2, Gamma aminobutyric acid (GABA) A receptor gamma 3, Gamma aminobutyric acid (GABA) A receptor pi, Gamma aminobutyric acid (GABA) A receptor, beta 2, Gamma aminobutyric acid A receptor alpha 1, Gamma aminobutyric acid A receptor alpha 3, Gamma aminobutyric acid A receptor alpha 4, Gamma aminobutyric acid A receptor alpha 6, Gamma aminobutyric acid A receptor beta 2, Gamma aminobutyric acid A receptor gamma 2, Gamma aminobutyric acid A receptor gamma 3, Gamma aminobutyric acid A receptor pi, Gamma aminobutyric acid A receptor, gamma 1, Gamma aminobutyric acid GABA A receptor alpha 5, Gamma aminobutyric acid GABA A receptor alpha 5 precursor, Gamma aminobutyric acid GABA A receptor alpha 6, Gamma aminobutyric acid GABA A receptor delta, Gamma aminobutyric acid receptor alpha 4 subunit, Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor, Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor, Gamma aminobutyric acid receptor gamma 2 subunit, Gamma aminobutyric acid receptor pi subunit, Gamma aminobutyric acid type A receptor alpha1 subunit, Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-3, Gamma-aminobutyric acid receptor subunit alpha-4, Gamma-aminobutyric acid receptor subunit alpha-5, Gamma-aminobutyric acid receptor subunit alpha-6, Gamma-aminobutyric acid receptor subunit beta-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit delta, Gamma-aminobutyric acid receptor subunit gamma-1, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit gamma-3, Gamma-aminobutyric acid receptor subunit pi, Gamma-aminobutyric-acid receptor subunit beta-2, Gastrin receptor, Gastrin/cholecystokinin type B receptor, Gastrin\cholecystokinin brain receptor, Glucocorticoid inducible P450, H(+)/organic cation antiporter kidney-specific, H+/organic cation antiporter, H-ERG, HLP, HM1, HT1DA, HTR 2, HTR 2A, HTR 4, HTR1D, HTR1D2, HTR1DA, HTR1DB, HTR2, formerly, HTR2C, HTR3, HTRL, Htr 2b, Htr1b, Htr1c, Htr3a, Htr3b, KCNH2_HUMAN, Kidney-specific H(+)/organic cation antiporter, Kv11.1, LMOR, LQT 2, M-OR-1, MATE-1, MATE-2, MATE2 B, MATE2 K, MGC116903, MGC116904, MGC120035, MGC120036, MGC120037, MGC126386, MGC126387, MGC126680, MGC33793, MGC45284, MGC6482, MGC9051, MOR, Mu opiate receptor, Mu opioid receptor, Mu-type opioid receptor, Multidrug and toxin extrusion 2, Multidrug and toxin extrusion protein 1, Multidrug and toxin extrusion protein 2, Muscarinic acetylcholine receptor M1, N-ACHE, NF 25, NP75 protein, Nifedipine oxidase, OPRM1, OPRM_HUMAN, Opioid receptor mu 1, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Quinine 3-monooxygenase, RDC4, S47A1_HUMAN, S47A2_HUMAN, SEROTONIN 5-HT-3E RECEPTOR, SEROTONIN 5HT2B RECEPTOR, SLC47A1, SLC47A2, SQT1, Serotonin 1D alpha receptor, Serotonin 1D beta receptor, Serotonin 5-HT-2C receptor, Serotonin gated ion channel subunit, Serotonin receptor 1B, Serotonin receptor 1D, Serotonin receptor 2A, Serotonin receptor 2B, Serotonin receptor 2C, Serotonin receptor 3A, Serotonin receptor 3B, Serotonin receptor 3C, Serotonin receptor 3E, Serotonin receptor 4, Serotonin-gated ion channel receptor, Serotonin-gated ion channel receptor 3a, Solute carrier family 47 member 1, Solute carrier family 47 member 2, Stomach fundus serotonin receptor, Taurochenodeoxycholate 6-alpha-hydroxylase, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, YT, YT blood group, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, eag homolog, hERG-1, hMATE-1, hMATE-2, hMOP, multidrug and toxin extrusion 1, serotonin 1c receptor, serotonin 2c receptor, serotonin 4 receptor, serotonin 5-HT-2 receptor, formerly, serotonin 5-HT-2A receptor, serotonin 5-ht-4 receptor, serotonin 5-ht-4a, serotonin receptor 3 subunit E
- Chemical Structure
Lab
Chemical Structure - Ondansetron, 5-HT3antagonist (AB120134)
2D chemical structure image of ab120134, Ondansetron, 5-HT3antagonist
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Proteins like AChE maintain neurotransmitter balance by degrading acetylcholine ensuring proper nerve signal termination. The GABA A receptors including subunits like GABRB2 GABRA3 and GABRG2 are integral to chloride channel function promoting inhibitory signaling within neuron complexes. CYP3A4 is part of the cytochrome P450 family and contributes to xenobiotic metabolism affecting drug processing. These proteins can be part of larger complexes that facilitate neurotransmission influencing synaptic plasticity and signal transduction.
Pathways
Several of these targets take part in critical signaling cascades. AChE functions in the acetylcholine pathways directly impacting neuromuscular and central nervous system nodes. Similarly the GABA A receptor subunit family including GABRA4 and GABRB1 figures prominently in GABAergic signaling pathways that regulate neuronal excitability. CYP3A4 is pivotal in the drug metabolism and xenobiotic pathways interacting with proteins like Mu Opioid Receptor (MOR) which are relevant for drug efficacy and detoxification processes.
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