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MW 563.6 Da, Purity >98%. Potent, cell-permeable, O-GlcNAc transferase (OGT) inhibitor. Inhibits protein O-GlcNAcylation in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.

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Publications

Key facts

CAS number

1681056-61-0

Purity

> 98%

Form

Solid

Molecular weight

563.6 Da

Molecular formula

C28H25N3O6S2

PubChem identifier

118634407

Nature

Synthetic

Target data

Recommended products

MW 563.6 Da, Purity >98%. Potent, cell-permeable, O-GlcNAc transferase (OGT) inhibitor. Inhibits protein O-GlcNAcylation in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.

Key facts

Purity

> 98%

PubChem identifier

118634407

Solubility

DMSO ~20 mg/mL.

Biochemical name

(R)-N-(furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide

Biological description

Potent, cell-permeable, O-GlcNAc transferase (OGT) inhibitor. Inhibits protein O-GlcNAcylation in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.

Canonical SMILES

COC1=CC=CC=C1C(C(=O)N(CC2=CC=CO2)CC3=CC=CS3)NS(=O)(=O)C4=CC5=C(C=C4)NC(=O)C=C5

Isomeric SMILES

COC1=CC=CC=C1[C@H](C(=O)N(CC2=CC=CO2)CC3=CC=CS3)NS(=O)(=O)C4=CC5=C(C=C4)NC(=O)C=C5

InChI

InChI=1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1

InChIKey

IYIGLWQQAMROOF-HHHXNRCGSA-N

IUPAC name

(2R)-N-(furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-[(2-oxo-1H-quinolin-6-yl)sulfonylamino]-N-(thiophen-2-ylmethyl)acetamide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store in the dark, Store under desiccating conditions

Notes

This product is manufactured by BioVision, an Abcam company and was previously called B1916 OSMI-1. B1916-5 is the same size as the 5 mg size of ab235455.

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