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AB120748

Ouabain octahydrate, Na+/K+ ATPase inhibitor

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(2 Publications)

MW 728.78 g/mol, Purity >97%. Na+/K+ ATPase inhibitor (Ki = 30 μM). Cardiac glycoside. Stimulates activity at low nanomolar concentrations in rats. Improves cardiac function in myocardial infarction rats. Centrally active following oral administration.
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Chemical Structure - Ouabain octahydrate, Na+/K+ ATPase inhibitor (AB120748)
  • Chemical Structure

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Chemical Structure - Ouabain octahydrate, Na+/K+ ATPase inhibitor (AB120748)

2D chemical structure image of ab120748, Ouabain octahydrate, Na+/K+ ATPase inhibitor

Key facts

CAS number

11018-89-6

Purity

>97%

Form

Solid

form

Source

ripe seeds of African plants Strophanthus gratus and the bark of Acokanthera ouabaio

Molecular weight

728.78 g/mol

Nature

Native

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 10 mM

Soluble in water to 10 mM

Biological description

Na+/K+ ATPase inhibitor (Ki = 30 μM). Cardiac glycoside. Stimulates activity at low nanomolar concentrations in rats. Improves cardiac function in myocardial infarction rats. Centrally active following oral administration.

IUPAC Name

(1β,3β,5β,11α)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide

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Product details

It has been reported that an aqueous solution of this material stored overnight in a borosilicate glass vial leads to the formation of ouabain-borate complexes.
It is therefore recommended that this material is stored in a plastic vial and any contact with borosilicate glass is minimised.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 15:1433137 PubMed39295937

2024

PFKFB3 deprivation attenuates the cisplatin resistance via blocking its autophagic elimination in colorectal cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Qianqian Li,Jianxing Ma,Yaqin Zhang,Fengyao Sun,Wen Li,Wenzhi Shen,Zhiying Ai,Changli Li,Shanshan Wang,Xiaonan Wei,Siyuan Yan

Nature communications 13:7136 PubMed36414629

2022

Activated astrocytes attenuate neocortical seizures in rodent models through driving Na-K-ATPase.

Applications

Unspecified application

Species

Unspecified reactive species

Junli Zhao,Jinyi Sun,Yang Zheng,Yanrong Zheng,Yuying Shao,Yulan Li,Fan Fei,Cenglin Xu,Xiuxiu Liu,Shuang Wang,Yeping Ruan,Jinggen Liu,Shumin Duan,Zhong Chen,Yi Wang
View all publications
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