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AB141054

Oxaliplatin, Platinum anticancer agent

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(5 Publications)

MW 397.29 g/mol, Purity >99%. Diaminocyclohexane platinum anticancer agent. Induces DNA cross-linking and blocks DNA synthesis. Induces apoptosis and cell cycle arrest.
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Chemical Structure - Oxaliplatin, Platinum anticancer agent (AB141054)
  • Chemical Structure

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Chemical Structure - Oxaliplatin, Platinum anticancer agent (AB141054)

2D chemical structure image of ab141054, Oxaliplatin, Platinum anticancer agent

Key facts

CAS number

61825-94-3

Purity

>99%

Form

Solid

form

Molecular weight

397.29 g/mol

Molecular formula

C<sub>8</sub>H<sub>1</sub><sub>4</sub>N<sub>2</sub>O<sub>4</sub>Pt

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Diaminocyclohexane platinum anticancer agent. Induces DNA cross-linking and blocks DNA synthesis. Induces apoptosis and cell cycle arrest.

IUPAC Name

(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN1,kN2][ethanedioato(2-)-kO1,kO2]-platinum

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:5024 PubMed37596278

2023

An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos Fernández Moro,Natalie Geyer,Sara Harrizi,Yousra Hamidi,Sara Söderqvist,Danyil Kuznyecov,Evelina Tidholm Qvist,Media Salmonson Schaad,Laura Hermann,Amanda Lindberg,Rainer L Heuchel,Alfonso Martín-Bernabé,Soniya Dhanjal,Anna C Navis,Christina Villard,Andrea C Del Valle,Lorand Bozóky,Ernesto Sparrelid,Luc Dirix,Carina Strell,Arne Östman,Bernhard Schmierer,Peter B Vermeulen,Jennie Engstrand,Béla Bozóky,Marco Gerling

Aging 12: PubMed33495407

2021

Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS.

Applications

Unspecified application

Species

Unspecified reactive species

Dongfang Li,Yuying Kou,Yuan Gao,Shanshan Liu,Panpan Yang,Tomoka Hasegawa,Rongjian Su,Jie Guo,Minqi Li

International journal of molecular sciences 20: PubMed31671668

2019

PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Siyuan Yan,Nan Zhou,Deru Zhang,Kaile Zhang,Wenao Zheng,Yonghua Bao,Wancai Yang

Molecular biology of the cell 30:42-55 PubMed30379607

2018

Environmental stresses induce karyotypic instability in colorectal cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zhihao Tan,Yong Jie Andrew Chan,Ying Jie Karen Chua,Samuel D Rutledge,Norman Pavelka,Daniela Cimini,Giulia Rancati

Scientific reports 8:3593 PubMed29483523

2018

Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs.

Applications

Unspecified application

Species

Unspecified reactive species

Jorge Vallecillo-Hernández,Maria Dolores Barrachina,Dolores Ortiz-Masiá,Sandra Coll,Juan Vicente Esplugues,Sara Calatayud,Carlos Hernández
View all publications
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