MW 1007.2 Da, Purity >95%. Oxytocin, Reproductive hormone. Achieve your results faster with highly validated, pure and trusted compounds.
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- International journal of molecular sciences 24:2023Highly Specific Detection of Oxytocin in Saliva.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMuhit Rana,Nimet Yildirim,Nancy E Ward,Stephanie P Vega,Michael J Heffernan,Avni A ArgunPubMed 36902261
- Molecular and cellular endocrinology 514:1109032020The effects of oxytocin to rectify metabolic dysfunction in obese mice are associated with increased thermogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJin Yuan et. al.PubMed 32531419
- Neuroscience research 153:56-612019Oxytocin administration modulates rats' helping behavior depending on social context.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAtsuhito Yamagishi et. al.PubMed 30953682
- Molecular endocrinology (Baltimore, Md.) 26:1743-562012Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJason N A Pont et. al.PubMed 22902539
- Biochemical Society transactions 35:1252-72007Stimuli and consequences of dendritic release of oxytocin within the brain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesI D NeumannPubMed 17956324
- Seminars in reproductive medicine 25:52-92007Regulation of oxytocin receptors and oxytocin receptor signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndrew M Blanks,Anatoly Shmygol,Steven ThorntonPubMed 17205423
- Endocrine regulations 39:97-1052006Oxytocin--anatomy and functional assignments: a minireview.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexander Kiss,Jens D MikkelsenPubMed 16468232
Key facts
- CAS number
50-56-6
- Purity
> 95%
- Form
Solid
- Molecular weight
1007.2 Da
- Molecular formula
C43H66N12O12S2
- PubChem identifier
439302
- Nature
Synthetic
Alternative names
ADHR, AVP R2, AVPR 1, AVPR 1A, AVPR V1a, AVPR V1b, AVPR V2, AVPR V3, AVPR3, Antidiuretic hormone receptor, Antidiuretic hormone receptor 1a, Antidiuretic hormone receptor 1b, Antidiuretic hormone, receptor for, V1B, Arginine vasopressin receptor 1A, Arginine vasopressin receptor 1B, Arginine vasopressin receptor 2, Arginine vasopressin receptor 3, DI1, DIR, DIR 3, MGC126533, MGC138386, NDI, Nephrogenic diabetes insipidus, Pituitary vasopressin receptor 3, Renal-type arginine vasopressin receptor, SCCL vasopressin subtype 1a receptor, V1 vascular vasopressin receptor AVPR1A, V1AR_HUMAN, V1BR_HUMAN, V1a vasopressin receptor, V2 receptor, V2R_HUMAN, VPR3, Vascular/hepatic-type arginine vasopressin receptor, Vasopressin V1a receptor, Vasopressin V1b receptor, Vasopressin V2, Vasopressin V2 receptor, Vasopressin V3 receptor
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MW 1007.2 Da, Purity >95%. Oxytocin, Reproductive hormone. Achieve your results faster with highly validated, pure and trusted compounds.
Alternative names
ADHR, AVP R2, AVPR 1, AVPR 1A, AVPR V1a, AVPR V1b, AVPR V2, AVPR V3, AVPR3, Antidiuretic hormone receptor, Antidiuretic hormone receptor 1a, Antidiuretic hormone receptor 1b, Antidiuretic hormone, receptor for, V1B, Arginine vasopressin receptor 1A, Arginine vasopressin receptor 1B, Arginine vasopressin receptor 2, Arginine vasopressin receptor 3, DI1, DIR, DIR 3, MGC126533, MGC138386, NDI, Nephrogenic diabetes insipidus, Pituitary vasopressin receptor 3, Renal-type arginine vasopressin receptor, SCCL vasopressin subtype 1a receptor, V1 vascular vasopressin receptor AVPR1A, V1AR_HUMAN, V1BR_HUMAN, V1a vasopressin receptor, V2 receptor, V2R_HUMAN, VPR3, Vascular/hepatic-type arginine vasopressin receptor, Vasopressin V1a receptor, Vasopressin V1b receptor, Vasopressin V2, Vasopressin V2 receptor, Vasopressin V3 receptor
Key facts
- CAS number
50-56-6
- Purity
> 95%
- Form
Solid
- Molecular weight
1007.2 Da
- Molecular formula
C43H66N12O12S2
- PubChem identifier
439302
- Nature
Synthetic
- Solubility
In water, 1.2X10+4 mg/L at 25 °C (est).
- Biochemical name
Oxytocin
- Canonical SMILES
CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
- Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
- InChI
InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
- InChIKey
XNOPRXBHLZRZKH-DSZYJQQASA-N
- IUPAC name
(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The AVPR1B AVPR2 (also known as V2R) and AVPR1A (also known as V1aR) are all part of the vasopressin receptor family. These receptors are G protein-coupled receptors (GPCRs) activated by the peptide hormone arginine vasopressin. These receptors mediate a variety of vasopressin's physiological effects in the body. The AVPR1B mostly appears in the anterior pituitary where it influences stress responses by modulating the release of adrenocorticotropic hormone (ACTH). AVPR2 is mostly expressed in the kidney playing a critical role in osmoregulation and AVPR1A is widely distributed impacting social behavior and circulation. The molecular mass of each receptor varies with AVPR2 around 40 kDa.
- Biological function summary
These receptors transduce signals through the cyclic adenosine monophosphate (cAMP) pathway and phosphatidylinositol (PI) signaling. AVPR1B functions in the pituitary as part of the hypothalamic-pituitary-adrenal (HPA) axis. AVPR2 in the nephron facilitates the antidiuretic effect of vasopressin concentrating urine and maintaining water balance. Meanwhile AVPR1A influences cardiovascular functions and regulates blood pressure and volume. These receptors are independently functional not forming large protein complexes but they still coordinate important physiological processes in conjunction with vasopressin.
- Pathways
These receptors connect primarily within the pituitary-adrenal axis and renal water reabsorption pathways. The AVPR1B receptor contributes significantly to the stress pathway through modulation of corticotrophin release in conjunction with corticotrophin-releasing hormone (CRH). AVPR2 is integral to the renal collecting duct's response in the antidiuretic pathway where it partners with aquaporin-2 to facilitate water reabsorption. Through these pathways vasopressin receptors ensure maintenance of fluid homeostasis and stress adaptation by interacting with other proteins such as CRH and aquaporin-2.
- Associated diseases and disorders
These receptors are linked to conditions like central diabetes insipidus and social anxiety disorders. AVPR2 mutations are well-documented in nephrogenic diabetes insipidus a condition where the kidneys fail to concentrate urine resulting in excessive waste of water. Dysfunctional AVPR1A and AVPR1B have implications in mental health disorders influencing conditions such as stress-related social anxiety due to their impact on HPA axis regulation. These connections emphasize the therapeutic potential targeting these receptors might have in treating such disorders by modulating related proteins like CRH and ACTH.
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Chemical Structure - Oxytocin, Reproductive hormone (ab120186)
2D chemical structure image of ab120186, Oxytocin, Reproductive hormone
Functional Studies - Oxytocin, Reproductive hormone (ab120186)
ab87312 staining oxytocin receptor in MCF7 cells treated with oxytocin (ab120186), by ICC/IF. Increase of cytoplasmatic oxytocin receptor localization and correspondent decrease in nuclear oxytocin receptor correlates with increased concentration of oxytocin, as described in literature.
The cells were incubated at 37°C for 15 minutes in media containing different concentrations of ab120186 (oxytocin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab87312 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 donkey anti-goat polyclonal antibody (Donkey Anti-Goat IgG H&L (DyLight® 488) ab96931) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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