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AB120186

Oxytocin, Reproductive hormone

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(5 Publications)

MW 1007.2 Da, Purity >95%. Achieve your results faster with highly validated, pure and trusted compounds.
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Functional Studies - Oxytocin, Reproductive hormone (AB120186)
  • FuncS

Unknown

Functional Studies - Oxytocin, Reproductive hormone (AB120186)

ab87312 staining oxytocin receptor in MCF7 cells treated with oxytocin (ab120186), by ICC/IF. Increase of cytoplasmatic oxytocin receptor localization and correspondent decrease in nuclear oxytocin receptor correlates with increased concentration of oxytocin, as described in literature.
The cells were incubated at 37°C for 15 minutes in media containing different concentrations of ab120186 (oxytocin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab87312 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 donkey anti-goat polyclonal antibody (ab96931) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Oxytocin, Reproductive hormone (AB120186)
  • Chemical Structure

Lab

Chemical Structure - Oxytocin, Reproductive hormone (AB120186)

2D chemical structure image of ab120186, Oxytocin, Reproductive hormone

Key facts

CAS number

50-56-6

Purity

>95%

Form

Solid

form

Molecular weight

1007.2 Da

Molecular formula

C<sub>4</sub><sub>3</sub>H<sub>6</sub><sub>6</sub>N<sub>1</sub><sub>2</sub>O<sub>1</sub><sub>2</sub>S<sub>2</sub>

PubChem

439302

Nature

Synthetic

Solubility

Soluble in water

Biochemical name

Oxytocin

Canonical smiles

CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N

Isomeric smiles

CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N

InChi

InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1

InChiKey

XNOPRXBHLZRZKH-DSZYJQQASA-N

IUPAC Name

(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

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Complementary Products

Assay Kits

AB242248

Human Oxytocin-neurophysin 1 Prepropeptide ELISA Kit

Recombinant|SimpleStep

ELISA - Human Oxytocin-neurophysin 1 Prepropeptide ELISA Kit (AB242248)

  • 0
  • 0
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104
Primary Antibodies

AB97959

Anti-SOX2 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOX2 antibody (AB97959)

  • 4
  • 75
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The AVPR1B AVPR2 (also known as V2R) and AVPR1A (also known as V1aR) are all part of the vasopressin receptor family. These receptors are G protein-coupled receptors (GPCRs) activated by the peptide hormone arginine vasopressin. These receptors mediate a variety of vasopressin's physiological effects in the body. The AVPR1B mostly appears in the anterior pituitary where it influences stress responses by modulating the release of adrenocorticotropic hormone (ACTH). AVPR2 is mostly expressed in the kidney playing a critical role in osmoregulation and AVPR1A is widely distributed impacting social behavior and circulation. The molecular mass of each receptor varies with AVPR2 around 40 kDa.
Biological function summary

These receptors transduce signals through the cyclic adenosine monophosphate (cAMP) pathway and phosphatidylinositol (PI) signaling. AVPR1B functions in the pituitary as part of the hypothalamic-pituitary-adrenal (HPA) axis. AVPR2 in the nephron facilitates the antidiuretic effect of vasopressin concentrating urine and maintaining water balance. Meanwhile AVPR1A influences cardiovascular functions and regulates blood pressure and volume. These receptors are independently functional not forming large protein complexes but they still coordinate important physiological processes in conjunction with vasopressin.

Pathways

These receptors connect primarily within the pituitary-adrenal axis and renal water reabsorption pathways. The AVPR1B receptor contributes significantly to the stress pathway through modulation of corticotrophin release in conjunction with corticotrophin-releasing hormone (CRH). AVPR2 is integral to the renal collecting duct's response in the antidiuretic pathway where it partners with aquaporin-2 to facilitate water reabsorption. Through these pathways vasopressin receptors ensure maintenance of fluid homeostasis and stress adaptation by interacting with other proteins such as CRH and aquaporin-2.

These receptors are linked to conditions like central diabetes insipidus and social anxiety disorders. AVPR2 mutations are well-documented in nephrogenic diabetes insipidus a condition where the kidneys fail to concentrate urine resulting in excessive waste of water. Dysfunctional AVPR1A and AVPR1B have implications in mental health disorders influencing conditions such as stress-related social anxiety due to their impact on HPA axis regulation. These connections emphasize the therapeutic potential targeting these receptors might have in treating such disorders by modulating related proteins like CRH and ACTH.
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 43:114380 PubMed38935503

2024

Cell-specific regulation of the circadian clock by BMAL1 in the paraventricular nucleus: Implications for regulation of systemic biological rhythms.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel Van Drunen,Yulin Dai,Haichao Wei,Baharan Fekry,Sina Noori,Samay Shivshankar,Rafael Bravo,Zhongming Zhao,Seung-Hee Yoo,Nicholas Justice,Jia Qian Wu,Qingchun Tong,Kristin Eckel-Mahan

Neuron 111:1795-1811.e7 PubMed37023755

2023

Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain.

Applications

Unspecified application

Species

Unspecified reactive species

Yaling Liu,Anna Li,Chloe Bair-Marshall,Helen Xu,Hyun Jung Jee,Elaine Zhu,Mengqi Sun,Qiaosheng Zhang,Arthur Lefevre,Zhe Sage Chen,Valery Grinevich,Robert C Froemke,Jing Wang

International journal of molecular sciences 24: PubMed36902261

2023

Highly Specific Detection of Oxytocin in Saliva.

Applications

Unspecified application

Species

Unspecified reactive species

Muhit Rana,Nimet Yildirim,Nancy E Ward,Stephanie P Vega,Michael J Heffernan,Avni A Argun

Molecular and cellular endocrinology 514:110903 PubMed32531419

2020

The effects of oxytocin to rectify metabolic dysfunction in obese mice are associated with increased thermogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Yuan,Rongping Zhang,Runze Wu,Yunjuan Gu,Yibing Lu

Neuroscience research 153:56-61 PubMed30953682

2019

Oxytocin administration modulates rats' helping behavior depending on social context.

Applications

Unspecified application

Species

Unspecified reactive species

Atsuhito Yamagishi,Maya Okada,Masatoshi Masuda,Nobuya Sato
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