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AB138910

p-Nitrobenzyl mesylate, Alkylation reagent

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(84 Publications)

p-Nitrobenzyl mesylate (PNMM)(CAS: 39628-94-9)(ab138910) is an alkylation reagent for the identification of direct kinase substrates. Used with ab92570 rabbit monoclonal anti-thiophosphate ester antibody and ab138911 ATP-gamma-S. MW 231.23, Purity >98%.

- Thiol-specific alkylating reagent
- Larger volume format available upon request

Key facts

CAS number

39628-94-9

Purity

>98%

Form

Solid

form

Molecular weight

231.23 Da

Molecular formula

C<sub>8</sub>H<sub>9</sub>NO<sub>5</sub>S

PubChem

18924794

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

4-Nitrobenzyl methanesulfonate

Biological description

An alkylation reagent to be used with ab92570 rabbit monoclonal anti-thiophosphate ester antibody and ab138911 ATP-gamma-S for the identification of direct kinase substrates.

Prepare a 50 mM PNBM (12 mg/ml) stock by dissolving PNBM in DMSO and vortexing.

One time use DMSO aliquots may be stored at -20°C.

Canonical smiles

CS(=O)(=O)OCC1=CC=C(C=C1)[N+](=O)[O-]

InChi

InChI=1S/C8H9NO5S/c1-15(12,13)14-6-7-2-4-8(5-3-7)9(10)11/h2-5H,6H2,1H3

InChiKey

QZIYKAFPHRTIAI-UHFFFAOYSA-N

IUPAC Name

(4-nitrophenyl)methyl methanesulfonate

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Complementary Products

Biochemicals

AB138911

ATP-gamma-S, Kinase substrate

Chemical Structure - ATP-gamma-S, Kinase substrate (AB138911)

  • 0
  • 0
Primary Antibodies

AB92570

Anti-Thiophosphate ester antibody [51-8]

RabMAb|Recombinant

Western blot - Anti-Thiophosphate ester antibody [51-8] (AB92570)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
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Product details

Check out our Alkylation reagents here
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (84)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 11:266 PubMed40467571

2025

ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis to sustain glioblastoma survival under glucose deprivation.

Applications

Unspecified application

Species

Unspecified reactive species

Yingping Li,Fenna Zhang,Fumin Hu,Rui Tong,Yueqi Wen,Guokai Fu,Xueli Bian

Frontiers in cell and developmental biology 13:1554958 PubMed40365021

2025

Omic AI reveals new autophagy regulators from the Atg1 interactome in .

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Han,Shanshan Fu,Dachao Tang,Yuting Chen,Dan Liu,Zihao Feng,Yujie Gou,Chi Zhang,Weizhi Zhang,Leming Xiao,Jiayi Zhang,Cong Yi,Yu Xue,Di Peng

Cell communication and signaling : CCS 23:194 PubMed40269955

2025

CDO1 phosphorylation is required for IL-6-induced tumor cell proliferation through governing cysteine availability.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Li,Zhe Zhao,Hongping Ye,Dan Li,Xiaoke Huang,Jong-Ho Lee,Rui Liu

Theranostics 15:2814-2833 PubMed40083925

2025

FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Siming Chen,Kangping Xiong,Jianmin Liu,Shijie Yao,Mingxing Li,Jingtian Yu,Gang Wang,Sheng Tu,Wan Jin,Jiageng Shi,Yu Xiao,Yi Zhang,Kaiyu Qian,Lingao Ju,Xinghuan Wang

Nature communications 16:2454 PubMed40074748

2025

Salt stress activates the CDK8-AHL10-SUVH2/9 module to dynamically regulate salt tolerance in Arabidopsis.

Applications

Unspecified application

Species

Unspecified reactive species

Pengcheng Guo,Leelyn Chong,Zhixin Jiao,Rui Xu,Qingfeng Niu,Yingfang Zhu

Science advances 11:eadt4548 PubMed40073115

2025

MLX phosphorylation stabilizes the ChREBP-MLX heterotetramer on tandem E-boxes to control carbohydrate and lipid metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Carla E Cadena Del Castillo,Onur Deniz,Femke van Geest,Lore Rosseels,Ingrid Stockmans,Marius Robciuc,Sebastien Carpentier,Bettina K Wölnerhanssen,Anne Christin Meyer-Gerspach,Ralph Peterli,Ville Hietakangas,Mitsugu Shimobayashi

Nature communications 16:1738 PubMed39966410

2025

Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK.

Applications

Unspecified application

Species

Unspecified reactive species

Chang Peng,Haowen Jiang,Liya Jing,Wenhua Yang,Xiaotong Guan,Hanlin Wang,Sike Yu,Yutang Cao,Min Wang,Huan Ma,Zan Lv,Hongyu Gu,Chunmei Xia,Xiaozhen Guo,Bin Sun,Aili Wang,Cen Xie,Wenbiao Wu,Luyiyi Lu,Jiayi Song,Saifei Lei,Rui Wu,Yi Zang,Erjiang Tang,Jia Li

mBio 16:e0292224 PubMed39817743

2025

Autoinducer-2 enhances the defense of against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system.

Applications

Unspecified application

Species

Unspecified reactive species

Heng Zhang,Wenjin Zhao,Wenguang Yang,Huimin Zhang,Xinyu Qian,Kai Sun,Qiao Yang,Xihui Shen,Lei Zhang

Nature communications 15:10782 PubMed39737931

2024

Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth M Black,Carlos Andrés Ramírez Parrado,Isabelle Trier,Wenxue Li,Yoon Ki Joo,Jennifer Pichurin,Yansheng Liu,Lilian Kabeche

Nature communications 15:10106 PubMed39572544

2024

Functional annotation of the Hippo pathway somatic mutations in human cancers.

Applications

Unspecified application

Species

Unspecified reactive species

Han Han,Zhen Huang,Congsheng Xu,Gayoung Seo,Jeongmin An,Bing Yang,Yuhan Liu,Tian Lan,Jiachen Yan,Shanshan Ren,Yue Xu,Di Xiao,Jonathan K Yan,Claire Ahn,Dmitry A Fishman,Zhipeng Meng,Kun-Liang Guan,Ruxi Qi,Ray Luo,Wenqi Wang
View all publications
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