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AB145873

p-Nitropifithrin-alpha, p53 inhibitor

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MW 398.3 Da, Purity >98%. Cell-permeable p53 inhibitor. Pifithrin-α (ab120478) analog and prodrug. Shows more potent antiapoptotic effects than pifithrin-α. Shows antiobesogenic and hepatoprotective effects in vivo. .
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Chemical Structure - p-Nitropifithrin-alpha, p53 inhibitor (AB145873)
  • Chemical Structure

Lab

Chemical Structure - p-Nitropifithrin-alpha, p53 inhibitor (AB145873)

2D chemical structure image of ab145873, p-Nitropifithrin-alpha, p53 inhibitor

Key facts

CAS number

389850-21-9

Purity

>98%

Form

Solid

form

Molecular weight

398.3 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>6</sub>BrN<sub>3</sub>O<sub>3</sub>S

PubChem

11553038

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

p-nitro-Pifithrin-alpha

Biological description

Cell-permeable p53 inhibitor. Pifithrin-α (ab120478) analog and prodrug. Shows more potent antiapoptotic effects than pifithrin-α. Shows antiobesogenic and hepatoprotective effects in vivo.

Canonical smiles

C1CCC2=C(C1)N(C(=N)S2)CC(=O)C3=CC=C(C=C3)[N+](=O)[O-].Br

InChi

InChI=1S/C15H15N3O3S.BrH/c16-15-17(12-3-1-2-4-14(12)22-15)9-13(19)10-5-7-11(8-6-10)18(20)21;/h5-8,16H,1-4,9H2;1H

InChiKey

NXPCMOGORSWOLH-UHFFFAOYSA-N

IUPAC Name

2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-nitrophenyl)ethanone;hydrobromide

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Product details

It is important to note that this product has been reported to be unstable under a variety of conditions. In addition to being unstable to light and air after extended periods of time, this product is extremely unstable in polar solvents such as DMSO. Within 6 hours a DMSO solution had been found to be completely converted into the tricyclic material. We therefore recommend this material is only stored as the solid form at -20°C (or below), with the exclusion of light and air, and any solutions are made up fresh and used immediately.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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Complementary Products

Biochemicals

AB120478

Pifithrin-alpha-HBr, p53 Inhibitor

Chemical Structure - Pifithrin-alpha-HBr, p53 Inhibitor (AB120478)

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Primary Antibodies

AB109199

Anti-p21 antibody [EPR3993]

KO Validated|RabMAb|Recombinant|Lab Essentials

Western blot - Anti-p21 antibody [EPR3993] (AB109199)

  • 4
  • 12
Primary Antibodies

AB26

Anti-p53 antibody [PAb 240]

KO Validated|Lab Essentials

Western blot - Anti-p53 antibody [PAb 240] (AB26)

  • 4
  • 56
Primary Antibodies

AB223847

Anti-CENPF antibody [EPR20406]

RabMAb|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-CENPF antibody [EPR20406] (AB223847)

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