MW 314.1 Da, Purity >99%. Potent chemopreventive agent. Inhibits tumorigenesisandcarcinogen-induced DNA methylation in vivo. Orally active.
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- Cancers 13:2021Targeting the IL-6/STAT3 Signalling Cascade to Reverse Tamoxifen Resistance in Estrogen Receptor Positive Breast Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHo Tsoi,Ellen P S Man,Ka Man Chau,Ui-Soon KhooPubMed 33806019
- International journal of molecular sciences 20:2019Extracellular Albumin Covalently Sequesters Selenocompounds and Determines Cytotoxicity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWenyi Zheng,Roberto Boada,Rui He,Tingting Xiao,Fei Ye,Laura Simonelli,Manuel Valiente,Ying Zhao,Moustapha HassanPubMed 31554226
Key facts
- CAS number
- 85539-83-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 314.1 Da
- Molecular formula
- C10H8N2Se2
- PubChem identifier
- 5708
- Nature
- Synthetic
Alternative names
AHH, Aryl hydrocarbon hydroxylase, CP 12, CP11, CP1A1_HUMAN, CP1A2_HUMAN, CP1B, CP1B1_HUMAN, CYP 1, CYP1A2, CYPIA1, CYPIA2, CYPIB1, Cytochrome P(3)450, Cytochrome P1 450 dioxin inducible, Cytochrome P1-450, Cytochrome P450 1A1, Cytochrome P450 1A2, Cytochrome P450 1B1, Cytochrome P450 4, Cytochrome P450 family 1 polypeptide 2, Cytochrome P450 family 1 subfamily A polypeptide 1, Cytochrome P450 family 1 subfamily A polypeptide 2, Cytochrome P450 family 1 subfamily B polypeptide 1, Cytochrome P450 form 6, Cytochrome P450 subfamily I (aromatic compound inducible) polypeptide 1, Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile), Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2, Cytochrome P450-C, Cytochrome P450-P1, Cytochrome P450-P3, Dioxin inducable P3 450, GLC3A, Microsomal monooxygenase, P(3)450, P1 450, P3 450, P450 4, P450 C, P450 P1, P450 P3, P450 form 4, P450 form 6, P450(PA), P4501B1, P450DX, Xenobiotic monooxygenase, flavoprotein-linked monooxygenase
Recommended products
MW 314.1 Da, Purity >99%. Potent chemopreventive agent. Inhibits tumorigenesisandcarcinogen-induced DNA methylation in vivo. Orally active.
Key facts
- CAS number
- 85539-83-9
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 314.1 Da
- Molecular formula
- C10H8N2Se2
- PubChem identifier
- 5708
- Nature
- Synthetic
- Solubility
Soluble in DMSO.
- Biochemical name
- 1,4-Phenylenebis(methylene)selenocyanate
- Biological description
Potent chemopreventive agent. Inhibits tumorigenesisandcarcinogen-induced DNA methylation in vivo. Orally active.
- Canonical SMILES
- C1=CC(=CC=C1C[Se]C#N)C[Se]C#N
- InChI
- InChI=1S/C10H8N2Se2/c11-7-13-5-9-1-2-10(4-3-9)6-14-8-12/h1-4H,5-6H2
- InChIKey
- QFTBWTJGZHUOAW-UHFFFAOYSA-N
- IUPAC name
- [4-(selenocyanatomethyl)phenyl]methyl selenocyanate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Cytochrome P450 family members CYP1A1 CYP1A2 and CYP1B1 serve as important enzymes in the metabolism of various xenobiotics and endogenous compounds. They are commonly known as part of the Cytochrome P450 superfamily and each exhibits different substrate specificities. The molecular weight of CYP1B1 for instance is approximately 60 kDa. These enzymes are mainly expressed in the liver but one can also find them in extrahepatic tissues such as the lungs and kidneys.
- Biological function summary
These enzymes are involved in the metabolism of carcinogens and drugs playing a role in their activation and detoxification. CYP1A1 CYP1A2 and CYP1B1 help convert procarcinogens into carcinogenic compounds. They do not function in a complex but interact with NADPH-Cytochrome P450 reductase for electron transfer needed in their enzymatic activity.
- Pathways
These enzymes are key players in the aryl hydrocarbon receptor (AhR) signaling pathway. They contribute to the metabolic activation of polycyclic aromatic hydrocarbons. CYP1B1 is particularly associated with the estrogen metabolism pathway wherein it catalyzes hydroxylation reactions. These pathways also include interactions with enzymes like glutathione S-transferases which further process the metabolites produced by CYP1A1 CYP1A2 and CYP1B1.
- Associated diseases and disorders
Dysregulation of CYP1A1 CYP1A2 and CYP1B1 enzyme activity relates to cancer and cardiovascular diseases. Overexpression or altered activity of these enzymes has correlations with lung cancer due to their role in activating tobacco-related carcinogens. In terms of cardiovascular conditions changes in estrogen metabolism involving CYP1B1 can have implications linking them with vascular diseases. CYP1B1 inhibitors are explored for their potential in chemopreventive strategies targeting these pathways and related protein interactions.
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1 product image
Chemical Structure - p-Xyleneselenocyanate (1,4-Phenylenebis(methylene)selenocyanate), chemopreventive agent (ab142600)
2D chemical structure image of ab142600, p-Xyleneselenocyanate (1,4-Phenylenebis(methylene)selenocyanate), chemopreventive agent
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