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AB142600

p-Xyleneselenocyanate (1,4-Phenylenebis(methylene)selenocyanate), chemopreventive agent

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(2 Publications)

MW 314.1 Da, Purity >99%. Potent chemopreventive agent. Inhibits tumorigenesis and carcinogen-induced DNA methylation in vivo. Orally active.

View Alternative Names

AHH, Aryl hydrocarbon hydroxylase, CP 12, CP11, CP1A1_HUMAN, CP1A2_HUMAN, CP1B, CP1B1_HUMAN, CYP 1, CYP1A2, CYPIA1, CYPIA2, CYPIB1, Cytochrome P(3)450, Cytochrome P1 450 dioxin inducible, Cytochrome P1-450, Cytochrome P450 1A1, Cytochrome P450 1A2, Cytochrome P450 1B1, Cytochrome P450 4, Cytochrome P450 family 1 polypeptide 2, Cytochrome P450 family 1 subfamily A polypeptide 1, Cytochrome P450 family 1 subfamily A polypeptide 2, Cytochrome P450 family 1 subfamily B polypeptide 1, Cytochrome P450 form 6, Cytochrome P450 subfamily I (aromatic compound inducible) polypeptide 1, Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile), Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2, Cytochrome P450-C, Cytochrome P450-P1, Cytochrome P450-P3, Dioxin inducable P3 450, GLC3A, Microsomal monooxygenase, P(3)450, P1 450, P3 450, P450 4, P450 C, P450 P1, P450 P3, P450 form 4, P450 form 6, P450(PA), P4501B1, P450DX, Xenobiotic monooxygenase, flavoprotein-linked monooxygenase

1 Images
Chemical Structure - p-Xyleneselenocyanate (1,4-Phenylenebis(methylene)selenocyanate), chemopreventive agent (AB142600)
  • Chemical Structure

Lab

Chemical Structure - p-Xyleneselenocyanate (1,4-Phenylenebis(methylene)selenocyanate), chemopreventive agent (AB142600)

2D chemical structure image of ab142600, p-Xyleneselenocyanate (1,4-Phenylenebis(methylene)selenocyanate), chemopreventive agent

Key facts

CAS number

85539-83-9

Purity

>99%

Form

Solid

form

Molecular weight

314.1 Da

Molecular formula

C<sub>1</sub><sub>0</sub>H<sub>8</sub>N<sub>2</sub>Se<sub>2</sub>

PubChem

5708

Nature

Synthetic

Solubility

Soluble in DMSO

Biochemical name

1,4-Phenylenebis(methylene)selenocyanate

Biological description

Potent chemopreventive agent. Inhibits tumorigenesis and carcinogen-induced DNA methylation in vivo. Orally active.

Canonical smiles

C1=CC(=CC=C1C[Se]C#N)C[Se]C#N

InChi

InChI=1S/C10H8N2Se2/c11-7-13-5-9-1-2-10(4-3-9)6-14-8-12/h1-4H,5-6H2

InChiKey

QFTBWTJGZHUOAW-UHFFFAOYSA-N

IUPAC Name

[4-(selenocyanatomethyl)phenyl]methyl selenocyanate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Cytochrome P450 family members CYP1A1 CYP1A2 and CYP1B1 serve as important enzymes in the metabolism of various xenobiotics and endogenous compounds. They are commonly known as part of the Cytochrome P450 superfamily and each exhibits different substrate specificities. The molecular weight of CYP1B1 for instance is approximately 60 kDa. These enzymes are mainly expressed in the liver but one can also find them in extrahepatic tissues such as the lungs and kidneys.
Biological function summary

These enzymes are involved in the metabolism of carcinogens and drugs playing a role in their activation and detoxification. CYP1A1 CYP1A2 and CYP1B1 help convert procarcinogens into carcinogenic compounds. They do not function in a complex but interact with NADPH-Cytochrome P450 reductase for electron transfer needed in their enzymatic activity.

Pathways

These enzymes are key players in the aryl hydrocarbon receptor (AhR) signaling pathway. They contribute to the metabolic activation of polycyclic aromatic hydrocarbons. CYP1B1 is particularly associated with the estrogen metabolism pathway wherein it catalyzes hydroxylation reactions. These pathways also include interactions with enzymes like glutathione S-transferases which further process the metabolites produced by CYP1A1 CYP1A2 and CYP1B1.

Dysregulation of CYP1A1 CYP1A2 and CYP1B1 enzyme activity relates to cancer and cardiovascular diseases. Overexpression or altered activity of these enzymes has correlations with lung cancer due to their role in activating tobacco-related carcinogens. In terms of cardiovascular conditions changes in estrogen metabolism involving CYP1B1 can have implications linking them with vascular diseases. CYP1B1 inhibitors are explored for their potential in chemopreventive strategies targeting these pathways and related protein interactions.
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancers 13: PubMed33806019

2021

Targeting the IL-6/STAT3 Signalling Cascade to Reverse Tamoxifen Resistance in Estrogen Receptor Positive Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ho Tsoi,Ellen P S Man,Ka Man Chau,Ui-Soon Khoo

International journal of molecular sciences 20: PubMed31554226

2019

Extracellular Albumin Covalently Sequesters Selenocompounds and Determines Cytotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Wenyi Zheng,Roberto Boada,Rui He,Tingting Xiao,Fei Ye,Laura Simonelli,Manuel Valiente,Ying Zhao,Moustapha Hassan
View all publications
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