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AB145872

p38 MAP Kinase Inhibitor, p38 MAPK inhibitor

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(1 Publication)

MW 365.79 g/mol, Purity >98%. Potent p38 MAPK inhibitor (IC50 = 35 nM).

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Chemical Structure - p38 MAP Kinase Inhibitor, p38 MAPK inhibitor (AB145872)
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Chemical Structure - p38 MAP Kinase Inhibitor, p38 MAPK inhibitor (AB145872)

2D chemical structure image of ab145872, p38 MAP Kinase Inhibitor, p38 MAPK inhibitor

Key facts

CAS number

219138-24-6

Purity

>98%

Form

Solid

form

Molecular weight

365.79 g/mol

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>1</sub><sub>3</sub>ClFN<sub>3</sub>O

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biological description

Potent p38 MAPK inhibitor (IC50 = 35 nM).

See similar compounds

Canonical smiles

C1=CC(=CC=C1C2=C(NN(C2=O)C3=CC=C(C=C3)CL)C4=CC=NC=C4)F

InChi

InChI=1S/C20H13ClFN3O/c21-15-3-7-17(8-4-15)25-20(26)18(13-1-5-16(22)6-2-13)19(24-25)14-9-11-23-12-10-14/h1-12,24H

InChiKey

DZFBYHUKZSRPHU-UHFFFAOYSA-N

IUPAC Name

2-(4-Chlorophenyl)-4-(4-fluorophenyl)-1,2-dihydro-5-(4-pyridinyl)-3H-pyrazol-3-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Antioxidants (Basel, Switzerland) 13: PubMed39456453

2024

NADPH Oxidase 5 (NOX5) Upregulates MMP-10 Production and Cell Migration in Human Endothelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Javier Marqués,Elena Ainzúa,Josune Orbe,María Martínez-Azcona,José Martínez-González,Guillermo Zalba
View all publications
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