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AB144602

P5091, USP-7 inhibitor

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MW 348.2 Da, Purity >98%. Potent, selective and cell-permeable USP-7 inhibitor (EC50 = 4.2 μM). Induces apoptosis in cancer cells in vitro. Antiangiogenic and antitumor agent. Active in vitro and in vivo.
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Chemical Structure - P5091, USP-7 inhibitor (AB144602)
  • Chemical Structure

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Chemical Structure - P5091, USP-7 inhibitor (AB144602)

2D chemical structure image of ab144602, P5091, USP-7 inhibitor

Key facts

CAS number

882257-11-6

Purity

>98%

Form

Solid

form

Molecular weight

348.2 Da

Molecular formula

C<sub>1</sub><sub>2</sub>H<sub>7</sub>Cl<sub>2</sub>NO<sub>3</sub>S<sub>2</sub>

PubChem

2819993

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM (with warming)

Soluble in ethanol to 100 mM (with warming)

Biochemical name

1-(5-(2,3-Dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone

Biological description

Potent, selective and cell-permeable USP-7 inhibitor (EC50 = 4.2 μM). Induces apoptosis in cancer cells in vitro. Antiangiogenic and antitumor agent. Active in vitro and in vivo.

Canonical smiles

CC(=O)C1=CC(=C(S1)SC2=C(C(=CC=C2)Cl)Cl)[N+](=O)[O-]

InChi

InChI=1S/C12H7Cl2NO3S2/c1-6(16)10-5-8(15(17)18)12(20-10)19-9-4-2-3-7(13)11(9)14/h2-5H,1H3

InChiKey

LKZLGMAAKNEGCH-UHFFFAOYSA-N

IUPAC Name

1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitrothiophen-2-yl]ethanone

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Toxic, refer to SDS for further information.

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Product protocols

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Product promise

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