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MW 392.5 Da, Purity >95%. Potent caspase-3 activator (IC50 = 220 nM). Also activates caspase-7 (IC50 = 4.5 μM). Proapoptotic in vitro. Anticancer activity in vivo. Orally active.
- CAS number
315183-21-2
- Purity
> 95%
- Form
Solid
- Molecular weight
392.5 Da
- Molecular formula
C23H28N4O2
- PubChem identifier
6851947
- Nature
Synthetic
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MW 392.5 Da, Purity >95%. Potent caspase-3 activator (IC50 = 220 nM). Also activates caspase-7 (IC50 = 4.5 μM). Proapoptotic in vitro. Anticancer activity in vivo. Orally active.
Key facts
- CAS number
315183-21-2
- Purity
> 95%
- Form
Solid
- Molecular weight
392.5 Da
- Molecular formula
C23H28N4O2
- PubChem identifier
6851947
- Nature
Synthetic
- Biochemical name
CID 6851947
- Biological description
Potent caspase-3 activator (IC50 = 220 nM). Also activates caspase-7 (IC50 = 4.5 μM). Proapoptotic in vitro. Anticancer activity in vivo. Orally active.
- Canonical SMILES
C=CCC1=CC=CC(=CNNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)C1=O
- Isomeric SMILES
C=CCC1=CC=C/C(=C/NNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)/C1=O
- InChI
InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,24H,1,7,12-15,17-18H2,(H,25,28)/b21-16-
- InChIKey
XSGXRYNZNGUGEJ-PGMHBOJBSA-N
- IUPAC name
2-(4-benzylpiperazin-1-yl)-N'-[(Z)-(6-oxo-5-prop-2-enylcyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
+4°C
- Storage information
The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 1654 PAC-1. 1654-10 is the same size as the 10 mg size of ab142074.
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