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AB142074

PAC-1, caspase-3 activator

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(1 Publication)

MW 392.5 Da, Purity >95%. Potent caspase-3 activator (IC50 = 220 nM). Also activates caspase-7 (IC50 = 4.5 μM). Proapoptotic in vitro. Anticancer activity in vivo. Orally active.
1 Images
Chemical Structure - PAC-1, caspase-3 activator (AB142074)
  • Chemical Structure

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Chemical Structure - PAC-1, caspase-3 activator (AB142074)

2D chemical structure image of ab142074, PAC-1, caspase-3 activator

Key facts

CAS number

315183-21-2

Purity

>95%

Form

Solid

form

Molecular weight

392.5 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>8</sub>N<sub>4</sub>O<sub>2</sub>

PubChem

6851947

Nature

Synthetic

Solubility

Soluble in water to 5 mM

Soluble in DMSO to 25 mM

Biochemical name

CID 6851947

Biological description

Potent caspase-3 activator (IC50 = 220 nM). Also activates caspase-7 (IC50 = 4.5 μM). Proapoptotic in vitro. Anticancer activity in vivo. Orally active.

Canonical smiles

C=CCC1=CC=CC(=CNNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)C1=O

Isomeric smiles

C=CCC1=CC=C/C(=C/NNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)/C1=O

InChi

InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,24H,1,7,12-15,17-18H2,(H,25,28)/b21-16-

InChiKey

XSGXRYNZNGUGEJ-PGMHBOJBSA-N

IUPAC Name

2-(4-benzylpiperazin-1-yl)-N'-[(Z)-(6-oxo-5-prop-2-enylcyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1654 PAC-1. 1654-10 is the same size as the 10 mg size of ab142074.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of 112:E5246-52 PubMed26372956

2015

Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah A Dick,Natasha C Chang,Nicolas A Dumont,Ryan A V Bell,Charis Putinski,Yoichi Kawabe,David W Litchfield,Michael A Rudnicki,Lynn A Megeney
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