(±)-Palmitoylcarnitine chloride, Protein kinase C (PKC) inhibitor
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MW 436.1 Da, Purity >98%. Protein kinase C (PKC) inhibitor. Intermediate in long-chain fatty acid metabolism able to disrupt cell membranes. Also available in simple stock solutions (ab146730) - add 1 ml of water to get an exact, ready-to-use concentration.
View Alternative Names
BAR, Bile acid receptor, Cytosolic NADP-isocitrate dehydrogenase, DNA replication inhibitor, Epididymis luminal protein 216, Epididymis secretory protein Li 26, Farnesoid X-activated receptor, Farnesol receptor HRR-1, GEMI_HUMAN, GMNN, Geminin, Geminin DNA replication inhibitor, HEL-216, HEL-S-26, HRR 1, HS90A_HUMAN, HSP 84, HSP 86, HSP 90, HSP 90 b, HSP90A, HSP90AA1, HSP90AB1, HSPC1, HSPC2, HSPCAL1, HSPCAL4, Heat shock 86 kDa, Heat shock protein 90kDa alpha cytosolic class A member 1, Heat shock protein 90kDa alpha cytosolic class B member 1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, OTTHUMP00000039393, Oxalosuccinate decarboxylase, PICD, RIP 14, RP3 369A17.3, RXR-interacting protein 14, Renal carcinoma antigen NY-REN-38, Retinoid X receptor-interacting protein 14
- FuncS
Unknown
Functional Studies - (±)-Palmitoylcarnitine chloride, Protein kinase C (PKC) inhibitor (AB141122)
ab59720 staining ZO1 in Caco-2 cells treated with (±)-palmitoylcarnitine chloride (ab141122), by ICC/IF. Membranar ZO1 expression loss correlates with increased concentration of (±)-palmitoylcarnitine chloride, as described in literature.
The cells were incubated at 37°C for 1 hour in media containing different concentrations of ab141122 ((±)-palmitoylcarnitine chloride) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab59720 (0.5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
- Chemical Structure
Unknown
Chemical Structure - (±)-Palmitoylcarnitine chloride, Protein kinase C (PKC) inhibitor (AB141122)
2D chemical structure of ab141122, (±)-Palmitoylcarnitine chloride, Protein kinase C (PKC) inhibitor
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Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Handling instructions
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Hsp90 chaperones stabilize numerous signaling proteins contributing to essential cellular processes such as cell growth and apoptosis. It forms a complex with co-chaperones to facilitate the folding and activation of client proteins some of which are critical oncogenes. Geminin inhibits DNA replication by binding to Cdt1 preventing it from initiating re-replication within a single cell cycle. This regulation ensures genomic integrity during cell division. IDH1 participates in cellular metabolism by contributing to the citric acid cycle and plays a role in protecting cells from oxidative damage through the production of NADPH.
Pathways
Hsp90 is integral to the signal transduction and stress response pathways interacting with proteins like protein kinase C (PKC) and steroid hormone receptors. These pathways are critical for cellular response to external stimuli and stress as well as for regulating cell cycle progression. Geminin is part of the DNA replication and cell cycle pathways; it regulates the transition between G1 and S phases in conjunction with cyclins and CDKs. IDH1 contributes to metabolic pathways including the citric acid cycle and lipid biosynthesis by regulating energy production and reducing equivalents.
Product promise
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