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AB144322

Paprotrain, MKLP-2 inhibitor

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MW 245.28 Da, Purity >98%. Selective cell-permeable MKLP-2 inhibitor. Reversible ATP-noncompetitive ATPase inhibitor (IC50 values are 1.35 and 0.83 μM for basal and microtubule-stimulated activity respectively). Inhibits Aurora B. Induces cell cycle arrest at early metaphase I.

View Alternative Names

AA415432, FLJ21151, GG10 2, GG10_2, KI20A_HUMAN, Kinesin-like protein 174, Kinesin-like protein KIF20A, MKLP 2, Mitotic kinesin-like protein 2, OTTHUMP00000159481, RAB6 KIFL, RAB6 interacting, kinesin like (rabkinesin6), RAB6-INTERACTING PROTEIN, KINESIN-LIKE, Rab6-interacting kinesin-like protein, Rabkinesin-6, kinesin family member 20A

1 Images
Chemical Structure - Paprotrain, MKLP-2 inhibitor (AB144322)
  • Chemical Structure

Lab

Chemical Structure - Paprotrain, MKLP-2 inhibitor (AB144322)

2D chemical structure image of ab144322, Paprotrain, MKLP-2 inhibitor

Key facts

CAS number

57046-73-8

Purity

>98%

Form

Solid

form

Molecular weight

245.28 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>1</sub>N<sub>3</sub>

PubChem

12248889

Nature

Synthetic

Solubility

Soluble in DMSO to 5 mM

Biochemical name

Paprotrain

Biological description

Selective cell-permeable MKLP-2 inhibitor. Reversible ATP-noncompetitive ATPase inhibitor (IC50 values are 1.35 and 0.83 μM for basal and microtubule-stimulated activity respectively). Inhibits Aurora B. Induces cell cycle arrest at early metaphase I.

Canonical smiles

C1=CC=C2C(=C1)C(=CN2)C(=CC3=CN=CC=C3)C#N

Isomeric smiles

C1=CC=C2C(=C1)C(=CN2)/C(=C/C3=CN=CC=C3)/C#N

InChi

InChI=1S/C16H11N3/c17-9-13(8-12-4-3-7-18-10-12)15-11-19-16-6-2-1-5-14(15)16/h1-8,10-11,19H/b13-8+

InChiKey

YMYYQRZCCKBFBE-MDWZMJQESA-N

IUPAC Name

(Z)-2-(1H-indol-3-yl)-3-pyridin-3-ylprop-2-enenitrile

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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