MW 365.8 Da, Purity >99%. Potent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (Ki values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo.
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- Psychopharmacology 240:2403-24182023Continuous home cage monitoring of activity and sleep in mice during repeated paroxetine treatment and discontinuation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHelen M Collins,Raquel Pinacho,S K Eric Tam,Trevor Sharp,David M Bannerman,Stuart N PeirsonPubMed 37584734
- Journal of psychopharmacology (Oxford, England) 36:794-8052022Effect of selective serotonin reuptake inhibitor discontinuation on anxiety-like behaviours in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHelen M Collins,Raquel Pinacho,Dersu Ozdemir,David M Bannerman,Trevor SharpPubMed 35607713
- Journal of neurochemistry 115:438-4920105-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRaymond Mongeau,Cédric B P Martin,Caroline Chevarin,Rafael Maldonado,Michel Hamon,Patricia Robledo,Laurence LanfumeyPubMed 20796171
- The Journal of general physiology 135:333-532010P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEstelle Toulme et. al.PubMed 20231374
- CNS drug reviews 7:25-472001Paroxetine: a review.Applications:Unspecified applicationReactive species:Unspecified reactive speciesM Bourin,P Chue,Y GuillonPubMed 11420571
- The Journal of pharmacology and experimental therapeutics 283:1305-221998Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.Applications:Unspecified applicationReactive species:Unspecified reactive speciesM J Owens,W N Morgan,S J Plott,C B NemeroffPubMed 9400006
- Psychopharmacology 93:193-2001987Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesD R Thomas,D R Nelson,A M JohnsonPubMed 2962217
Key facts
- CAS number
78246-49-8
- Purity
> 99%
- Form
Solid
- Molecular weight
365.8 Da
- Molecular formula
C19H21ClFNO3
- PubChem identifier
62878
- Nature
Synthetic
Recommended products
MW 365.8 Da, Purity >99%. Potent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (Ki values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo.
Key facts
- CAS number
78246-49-8
- Purity
> 99%
- Form
Solid
- Molecular weight
365.8 Da
- Molecular formula
C19H21ClFNO3
- PubChem identifier
62878
- Nature
Synthetic
- Biochemical name
Paroxetine hydrochloride
- Biological description
Potent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (Ki values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo.
- Canonical SMILES
C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl
- Isomeric SMILES
C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl
- InChI
InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1
- InChIKey
GELRVIPPMNMYGS-RVXRQPKJSA-N
- IUPAC name
(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
+4°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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Chemical Structure - Paroxetine hydrochloride, 5-HT uptake inhibitor (ab120069)
2D chemical structure image of ab120069, Paroxetine hydrochloride, 5-HT uptake inhibitor
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