MW 365.8 Da, Purity >99%. Potent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (Ki values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo.
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- Psychopharmacology 240:2403-24182023Continuous home cage monitoring of activity and sleep in mice during repeated paroxetine treatment and discontinuation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHelen M Collins,Raquel Pinacho,S K Eric Tam,Trevor Sharp,David M Bannerman,Stuart N PeirsonPubMed 37584734
- Journal of psychopharmacology (Oxford, England) 36:794-8052022Effect of selective serotonin reuptake inhibitor discontinuation on anxiety-like behaviours in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHelen M Collins,Raquel Pinacho,Dersu Ozdemir,David M Bannerman,Trevor SharpPubMed 35607713
- Journal of neurochemistry 115:438-4920105-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRaymond Mongeau,Cédric B P Martin,Caroline Chevarin,Rafael Maldonado,Michel Hamon,Patricia Robledo,Laurence LanfumeyPubMed 20796171
- The Journal of general physiology 135:333-532010P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEstelle Toulme et. al.PubMed 20231374
Key facts
- CAS number
- 78246-49-8
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 365.8 Da
- Molecular formula
- C19H21ClFNO3
- PubChem identifier
- 62878
- Nature
- Synthetic
Recommended products
MW 365.8 Da, Purity >99%. Potent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (Ki values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo.
Key facts
- CAS number
- 78246-49-8
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 365.8 Da
- Molecular formula
- C19H21ClFNO3
- PubChem identifier
- 62878
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM and in ethanol to 100 mM.
- Biochemical name
- Paroxetine hydrochloride
- Biological description
Potent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (Ki values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo.
- Canonical SMILES
- C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl
- Isomeric SMILES
- C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl
- InChI
- InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1
- InChIKey
- GELRVIPPMNMYGS-RVXRQPKJSA-N
- IUPAC name
- (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - Paroxetine hydrochloride, 5-HT uptake inhibitor (ab120069)
2D chemical structure image of ab120069, Paroxetine hydrochloride, 5-HT uptake inhibitor
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