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AB142725

Patulin, fungal mycotoxin

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MW 154.12 Da, Purity >98%. Fungal mycotoxin, DNA damaging agent and induces ROS production. Apoptosis inducer via EGR-1 dependent ATF3 upregulation in vitro. Anti-bacterial, carcinogenic, mutagenic and anticancer agent. Active in vivo.

View Alternative Names

AI413597, AI838772, AW045860, AW493413, DDPAC, FLJ11090, FLJ31424, FTDP 17, G protein beta1/gamma2 subunit interacting factor 1, IMD42, MAPT, MAPTL, MGC104252, MGC112732, MGC129539, MGC134287, MGC138549, MGC156663, MSTD, MTBT1, MTBT2, Microtubule associated protein tau isoform 4, Microtubule-associated protein tau, Mtapt, NR1F3, Neurofibrillary tangle protein, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, PHF-tau, PPND, PPP1R103, Paired helical filament-tau, Protein phosphatase 1, regulatory subunit 103, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RNPTAU, RORG_HUMAN, RP24-311F12.2, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SCAN1, TAU_HUMAN, TOR, TYDP, TYDP1_HUMAN, Tauopathy and respiratory failure, Tauopathy and respiratory failure, included, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, pTau

1 Images
Chemical Structure - Patulin, fungal mycotoxin (AB142725)
  • Chemical Structure

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Chemical Structure - Patulin, fungal mycotoxin (AB142725)

2D chemical structure image of ab142725, Patulin, fungal mycotoxin

Key facts

CAS number

149-29-1

Purity

>98%

Form

Solid

form

Molecular weight

154.12 Da

Molecular formula

C<sub>7</sub>H<sub>6</sub>O<sub>4</sub>

PubChem

4696

Nature

Synthetic

Solubility

Soluble in the water and in ethanol

Biochemical name

Patulin

Biological description

Fungal mycotoxin, DNA damaging agent and induces ROS production. Apoptosis inducer via EGR-1 dependent ATF3 upregulation in vitro. Anti-bacterial, carcinogenic, mutagenic and anticancer agent. Active in vivo.

Canonical smiles

C1C=C2C(=CC(=O)O2)C(O1)O

InChi

InChI=1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2

InChiKey

ZRWPUFFVAOMMNM-UHFFFAOYSA-N

IUPAC Name

4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tau is a microtubule-associated protein also known as MAPT with a mass ranging from 45 to 65 kDa depending on its isoforms. It mainly expresses in neurons of the central nervous system where it stabilizes microtubules. TDP1 or tyrosyl-DNA phosphodiesterase 1 is a DNA repair enzyme found in many tissues with a molecular weight of approximately 68 kDa. ROR gamma retinoic acid-related orphan receptor gamma is a nuclear receptor with a mass of about 58 kDa expressed in immune cells like Th17 cells and involved in transcriptional regulation.
Biological function summary

Tau supports neuronal structure and function by binding to microtubules but it can accumulate pathologically to form neurofibrillary tangles. TDP1 participates in the repair of topoisomerase I-mediated DNA damage and functions as part of the DNA repair complex. Meanwhile ROR gamma regulates the transcription of genes important for immune responses impacting the differentiation of Th17 cells and influencing inflammation.

Pathways

Tau is strongly tied to the MAP kinase signaling pathway modulating neuronal responses through its regulation of microtubule stability. TDP1 plays a vital role in the nucleotide excision repair pathway where it interacts with key proteins involved in DNA repair such as topoisomerase I. ROR gamma partakes in the regulation of the IL-17 signaling pathway interacting with other nuclear receptors to modulate immune responses.

Tau is closely linked to Alzheimer's disease and other tauopathies where Tau aggregation disrupts microtubule function. TDP1 mutations associate with neurodegenerative disorders like SCAN1 as impaired DNA repair can lead to neuronal degeneration. ROR gamma is implicated in autoimmune diseases such as rheumatoid arthritis due to its role in the differentiation of pro-inflammatory Th17 cells.
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Product protocols

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