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AB289849

PD-0325901, Sterile-Filtered

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PD-0325901 (ab289849) is a selective and ATP non-competitive MEK1/2 inhibitor that suppresses phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.

Key facts

CAS number

391210-10-9

Purity

>98%

Form

Liquid

form

Molecular weight

482.19 g/mol

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>4</sub>F<sub>3</sub>IN<sub>2</sub>O<sub>4</sub>

Nature

Synthetic

Biological description

Selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.

Canonical smiles

C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O

InChi

InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1

InChiKey

SUDAHWBOROXANE-SECBINFHSA-N

IUPAC Name

N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide

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Complementary Products

Biochemicals

AB291107

CHIR99021, Sterile-Filtered

  • 0
  • 0
Biochemicals

AB120962

SB 415286, GSK3 inhibitor

Chemical Structure - SB 415286, GSK3 inhibitor (AB120962)

  • 0
  • 0
Biochemicals

AB120129

Y-27632 dihydrochloride, Rho kinase inhibitor

Functional Studies - Y-27632 dihydrochloride, Rho kinase inhibitor (AB120129)

  • 5
  • 2
Primary Antibodies

AB62341

Anti-RFP antibody

Lab Essentials

Western blot - Anti-RFP antibody (AB62341)

  • 4
  • 23
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Product details

5mM sterile-filtered solution in DMSO.

Check out our range of MEK inhibitor biochemicals here
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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