MW 482.19 g/mol, Purity >=98%. Selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.
391210-10-9
>= 98%
Liquid
482.19 g/mol
C16H14F3IN2O4
Synthetic
94 kDa B raf protein, AHR_HUMAN, Ah receptor, Aromatic hydrocarbon receptor, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, B Raf proto oncogene serine threonine protein kinase, B Raf proto oncogene, serine/threonine kinase, B raf 1, B-Raf proto-oncogene serine/threonine-protein kinase (p94), BRAF_HUMAN, CFC syndrome, CFC4, Cardiofaciocutaneous syndrome, Catabolin, Class E basic helix-loop-helix protein 76, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 2, Dual specificity mitogen-activated protein kinase kinase 5, EC 2.7.12.2, ERK activator kinase 1, ERK activator kinase 2, ERK-2, ERT1, Extracellular signal-regulated kinase 2, FLJ26075, FLJ95109, H1, HGNC:348, HsT17454, IFN beta inducing factor, IL 1, IL-1 beta, IL1B_HUMAN, IL1F2, Interleukin 1 beta precursor, Interleukin-1 beta, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAP kinase kinase 1, MAP kinase kinase 2, MAP kinase kinase 5, MAP kinase kinase MEK5b, MAP kinase/Erk kinase 1, MAP2K1, MAP2K2, MAP2K5, MAPK / ERK kinase 2, MAPK 1, MAPK/ERK kinase 1, MAPK/ERK kinase 5, MAPKK 1, MAPKK 2, MAPKK 5, MEK 1, MEK 2, MEKK 1, MGC126806, MGC138284, MK01_HUMAN, MKK 1, MKK 2, MKK5, MP2K1_HUMAN, MP2K2_HUMAN, MP2K5_HUMAN, Microtubule associated protein kinase kinase 2, Mitogen Activated Protein Kinase Kinase 1, Mitogen activated protein kinase kinase 2, Mitogen activated protein kinase kinase 2 p45, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, Murine sarcoma viral (v-raf) oncogene homolog B1, Murine sarcoma viral v raf oncogene homolog B1, NS7, OAF, OTTHUMP00000162031, OTTHUMP00000165826, OTTHUMP00000165827, Oncogen BRAF, Osteoclast activating factor, P38, P41, PRKM 2, PRKM1, PRKMK 1, PRKMK 2, PRKMK5, Preinterleukin 1 beta, Preinterleukin beta, Pro interleukin 1 beta, Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1), Protein kinase, mitogen-activated, kinase 5, Proto-oncogene B-Raf, Proto-oncogene c-Rmil, RAF, RAFB 1, RMIL, SAPKK5, SKK5, Serine/threonine-protein kinase B-raf, bHLHe76, cRmil, mitogen-activated protein kinase kinase 5, oncogene BRAF1, p42-MAPK, p94, protein kinase mitogen-activated kinase 1, protein kinase, mitogen-activated, 1, protein kinase, mitogen-activated, 2, protein tyrosine kinase ERK2, v raf murine sarcoma viral oncogene homolog B, v-Raf murine sarcoma viral oncogene homolog B1
MW 482.19 g/mol, Purity >=98%. Selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.
391210-10-9
>= 98%
Liquid
482.19 g/mol
C16H14F3IN2O4
Synthetic
Selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.
C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O
InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
SUDAHWBOROXANE-SECBINFHSA-N
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide
Blue Ice
-20°C
-20°C
This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
5mM sterile-filtered solution in DMSO
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