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AB141464

PD 150606, Calpain inhibitor

5

(1 Review)

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(5 Publications)

MW 306.12 Da, Purity >98%. Potent, selective and cell-permeable Ca2+-dependent calpain inhibitor (Ki values are 210 and 370 nM for calpain-1 and calpain-2 respectively). Non-competitive and non-peptide. Irreversibly inhibits ICa through AMPA receptors. Anti-ischemic effects in vivo. .

View Alternative Names

CALP80, CAN1_HUMAN, CAN2_HUMAN, CANP, CANP 1, CANP 2, CANP L2, CANP small subunit, CANPL 1, CANPml, CAPN 1, CAPN 2, Ca2 activated neutral protease, Calcium activated neutral proteinase, Calcium-activated neutral protease 2, catalytic subunit, Calcium-activated neutral proteinase 1, Calcium-activated neutral proteinase 2, Calcium-activated neutral proteinase small subunit, Calcium-dependent protease small subunit, Calcium-dependent protease small subunit 1, Calpain 1, Calpain 1, (mu/I) large subunit, Calpain 2 (m/II) large subunit, Calpain 2 large catalytic subunit, Calpain 2, large [catalytic] subunit, Calpain M-type, Calpain large polypeptide L2, Calpain mu-type, Calpain regulatory subunit, Calpain small subunit 1, Calpain, large polypeptide L1, Calpain-1 catalytic subunit, Calpain-1 large subunit, Calpain-2 catalytic subunit, Calpain-2 large subunit, Calpain2, Capa2, Cell proliferation inducing protein 30, Cell proliferation-inducing gene 30 protein, FLJ39928, M calpin, M type, M-calpain, Micromolar-calpain, Millimolar-calpain, Mu Calpain, mCANP, muCANP, muCL

1 Images
Chemical Structure - PD 150606, Calpain inhibitor (AB141464)
  • Chemical Structure

Lab

Chemical Structure - PD 150606, Calpain inhibitor (AB141464)

2D chemical structure image of ab141464, PD 150606, Calpain inhibitor

Key facts

CAS number

179528-45-1

Purity

>98%

Form

Solid

form

Molecular weight

306.12 Da

Molecular formula

C<sub>9</sub>H<sub>7</sub>IO<sub>2</sub>S

PubChem

9839500

Nature

Synthetic

Solubility

Soluble in DMSO to 25 mM

Biochemical name

3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid

Biological description

Potent, selective and cell-permeable Ca2+-dependent calpain inhibitor (Ki values are 210 and 370 nM for calpain-1 and calpain-2 respectively). Non-competitive and non-peptide. Irreversibly inhibits ICa through AMPA receptors. Anti-ischemic effects in vivo.

Canonical smiles

C1=CC(=CC=C1C=C(C(=O)O)S)I

Isomeric smiles

C1=CC(=CC=C1/C=C(/C(=O)O)\S)I

InChi

InChI=1S/C9H7IO2S/c10-7-3-1-6(2-4-7)5-8(13)9(11)12/h1-5,13H,(H,11,12)/b8-5-

InChiKey

DJCVSFWGKYHMKH-YVMONPNESA-N

IUPAC Name

(Z)-3-(4-iodophenyl)-2-sulfanylprop-2-enoic acid

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1906 PD 150, 606. 1906-25 is the same size as the 25 mg size of ab141464.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Calpain 2 also known as m-calpain and Calpain 1 known as u-calpain are calcium-dependent non-lysosomal cysteine proteases. They have an approximate mass of 80 kDa for the large catalytic subunit. These proteins exist ubiquitously across various tissues in mammals. Mechanically Calpain 2 and Calpain 1 modulate a multitude of cellular processes by cleaving specific substrates in a calcium-dependent manner. Both require different calcium concentrations for activation with Calpain 2 needing higher levels compared to Calpain 1.
Biological function summary

These calpains play important roles in cytoskeletal remodeling signal transduction and cell cycle progression. They function independently and do not belong to any larger complex. Their ability to specifically cleave substrates means they finely tune cellular functions and contribute to the cell’s response to various stimuli. Misregulation of Calpain activity may lead to developmental abnormalities or disease states reflecting their importance in controlled proteolysis within cells.

Pathways

Calpain 1 and Calpain 2 integrate into the calcium signaling and apoptosis pathways. They can modulate proteins such as the caspase precursors preventing unnecessary cell death and ensuring proper cell cycle regulation. Furthermore Calpain involvement in the Wnt signaling pathway affects cellular processes related to proliferation and differentiation. These interactions demonstrate Calpains’ connections to key cellular processes and how they influence both cell survival and development.

Aberrant Calpain activity is linked to muscular dystrophies and Alzheimer's disease. Overactivation of Calpain can cause excessive proteolysis contributing to muscle tissue degradation in muscular dystrophies. Similarly they may disrupt neuronal stability affecting proteins like tau in Alzheimer's disease which further relates Calpain malfunction to amyloid-beta accumulation. Therefore understanding and potentially modulating Calpain activity are key strategies in the therapeutic targeting of these conditions.
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed36233068

2022

Selective Calpain Inhibition Improves Functional and Histopathological Outcomes in a Canine Spinal Cord Injury Model.

Applications

Unspecified application

Species

Unspecified reactive species

Elsayed Metwally,Hatim A Al-Abbadi,Mohamed A Hashem,Yasmina K Mahmoud,Eman A Ahmed,Ahmed I Maaty,Ibrahim E Helal,Mahmoud F Ahmed

Cell research 31:433-449 PubMed32848200

2020

Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium.

Applications

Unspecified application

Species

Unspecified reactive species

Elsayed Metwally,Guoli Zhao,Qifu Wang,Yong Q Zhang

Neuropharmacology 174:108175 PubMed32492450

2020

Calpain inhibition ameliorates depression-like behaviors by reducing inflammation and promoting synaptic protein expression in the hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Zhujin Song,Fengming Shen,Zhengrong Zhang,Shengbing Wu,Guoqi Zhu

The Journal of neuroscience : the official journal 39:2776-2791 PubMed30705102

2019

Calcium-Activated Calpain Specifically Cleaves Glutamate Receptor IIA But Not IIB at the Neuromuscular Junction.

Applications

Unspecified application

Species

Unspecified reactive species

Elsayed Metwally,Guoli Zhao,Wenhua Li,Qifu Wang,Yong Q Zhang

American journal of translational research 9:1402-1409 PubMed28386365

2017

Calpain 1 regulates TGF-β1-induced epithelial-mesenchymal transition in human lung epithelial cells via PI3K/Akt signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wei-Jun Tan,Qiu-Yue Tan,Ting Wang,Min Lian,Li Zhang,Zhen-Shun Cheng
View all publications
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