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AB145523

PD 151746, Calpain inhibitor

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MW 237.25 g/mol, Purity >96%. Cell permeable, selective, non-peptidic calpain inhibitor (Ki values are 0.3 and 5 μM for calpain 1 and calpain 2, respectively). Stimulates phagocyte function via hFPR/hFPRL1 activation. Interacts with the Ca2+ calpain sites. Shows antiapoptotic effects.
1 Images
Chemical Structure - PD 151746, Calpain inhibitor (AB145523)
  • Chemical Structure

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Chemical Structure - PD 151746, Calpain inhibitor (AB145523)

2D chemical structure image of ab145523, PD 151746, Calpain inhibitor

Key facts

CAS number

179461-52-0

Purity

>96%

Form

Solid

form

Molecular weight

237.25 g/mol

Molecular formula

C<sub>1</sub><sub>1</sub>H<sub>8</sub>FNO<sub>2</sub>S

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Cell permeable, selective, non-peptidic calpain inhibitor (Ki values are 0.3 and 5 μM for calpain 1 and calpain 2, respectively). Stimulates phagocyte function via hFPR/hFPRL1 activation. Interacts with the Ca2+ calpain sites. Shows antiapoptotic effects.

Canonical smiles

C1=CC2=C(C=C1F)C(=CN2)C=C(C(=O)O)S

InChi

InChI=1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-

InChiKey

HWMQHECFXSVZGN-KMKOMSMNSA-N

IUPAC Name

3-(5-Fluoro-1H-indol-3-yl)-2-mercapto-2-propenoic acid

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Biochemicals

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Chemical Structure - PD 150606, Calpain inhibitor (AB141464)

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Biochemicals

AB145601

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Chemical Structure - MDL 28170 (Calpain Inhibitor III), calpain and cathepsin B inhibitor (AB145601)

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Biochemicals

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Assay Kits

AB65308

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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