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MW 237.25 g/mol, Purity >96%. Cell permeable, selective, non-peptidic calpain inhibitor (Ki values are 0.3 and 5 μM for calpain 1 and calpain 2, respectively). Stimulates phagocyte function via hFPR/hFPRL1 activation. Interacts with the Ca2+ calpain sites. Shows antiapoptotic effects.

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Images

Chemical Structure - PD 151746, Calpain inhibitor (AB145523), expandable thumbnail

Key facts

CAS number
179461-52-0
Purity
> 96%
Form
Solid
Molecular weight
237.25 g/mol
Molecular formula
C11H8FNO2S
Nature
Synthetic

Target data

Recommended products

MW 237.25 g/mol, Purity >96%. Cell permeable, selective, non-peptidic calpain inhibitor (Ki values are 0.3 and 5 μM for calpain 1 and calpain 2, respectively). Stimulates phagocyte function via hFPR/hFPRL1 activation. Interacts with the Ca2+ calpain sites. Shows antiapoptotic effects.

Key facts

Purity
> 96%
Solubility

Soluble in DMSO to 100 mM.

Biological description

Cell permeable, selective, non-peptidic calpain inhibitor (Ki values are 0.3 and 5 μM for calpain 1 and calpain 2, respectively). Stimulates phagocyte function via hFPR/hFPRL1 activation. Interacts with the Ca2+ calpain sites. Shows antiapoptotic effects.

Canonical SMILES
C1=CC2=C(C=C1F)C(=CN2)C=C(C(=O)O)S
InChI
InChI=1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
InChIKey
HWMQHECFXSVZGN-KMKOMSMNSA-N
IUPAC name
3-(5-Fluoro-1H-indol-3-yl)-2-mercapto-2-propenoic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

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1 product image

  • Chemical Structure - PD 151746, Calpain inhibitor (ab145523), expandable thumbnail

    Chemical Structure - PD 151746, Calpain inhibitor (ab145523)

    2D chemical structure image of ab145523, PD 151746, Calpain inhibitor

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Product protocols

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