PD 168393, EGFR inhibitor

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MW 369.2 Da, Purity >98%. Potent, irreversible, cell-permeable, selective EGFR inhibitor (IC₅₀ values are 0.7, 0.08, 5.7, 12 and 15 nM for EGF receptor tyrosine kinase, erbB1, erbB2, erbB4 and SK-BR-3, respectively). Binds to the catalytic domain. Inhibits cancer cell growth. Blocks reactive astrogliosis and shows neuroprotective effects in vivo. .

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4ICD, AGMX 1, ALS19, ASV, AT, ATK, AW259666, Agammaglobulinaemia tyrosine kinase, Avian erythroblastic leukemia viral (v erb b) oncogene homolog, Avian erythroblastic leukemia viral oncogene homolog 4, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4, Avian sarcoma virus, B lymphocyte kinase, B lymphoid tyrosine kinase, B-cell progenitor kinase, BLK nonreceptor tyrosine kinase, BLK_HUMAN, BMX non receptor tyrosine kinase, BMX_HUMAN, BONE MARROW KINASE, X-LINKED, BPK, BTK_HUMAN, Beta-interferon, Bone marrow tyrosine kinase gene in chromosome X protein, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, Bruton闂佺偨鍎查悰 Tyrosine Kinase, C SRC, C erb B2/neu protein, C syn protooncogene, CD340, CD340 antigen, CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, CerbB2, Cytoplasmic tyrosine-protein kinase BMX, E4ICD, EC 2.7.10.1, EC 2.7.10.2, EGFR_HUMAN, ERBB, ERBB1, ERBB2_HUMAN, ERBB4 intracellular domain, ERBB4_HUMAN, ETK, Epidermal growth factor receptor, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Epithelial and endothelial tyrosine kinase, Erb b2 receptor tyrosine kinase 2, ErbB-2 proto-oncogene, Errp, FYN oncogene related to SRC FGR YES, FYN_HUMAN, Fibroblast interferon, HER 2, HER 2/NEU, HER 3, HER 4, HER1, Herstatin, Human epidermal growth factor receptor 2, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, IMD 1, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, JAK L, JAK3 HUMAN, JAK3_HUMAN, Janus kinase 3, Janus kinase 3 (a protein tyrosine kinase, leukocyte), L-JAK, Leukocyte janus kinase, MDA BF 1, MGC 10442, MGC126261, MGC126262, MGC138404, MGC96956, MLN 19, MODY 11, Mer4, Metastatic lymph node gene 19 protein, NEU, NEU proto oncogene, NGL, NISBD2, NKT38, NTK 38, Neuro/glioblastoma derived oncogene homolog, Neuroblastoma/glioblastoma derived oncogene homolog, Neuronal CSRC tyrosine specific protein kinase, Neuronal SRC, Neuronal proto-oncogene tyrosine-protein kinase Src, OKT3 induced calcium influx regulator, OTTHUMP00000063593, OTTHUMP00000174476, OTTHUMP00000174477, Oncogen ERBB, Oncogene ERBB4, Oncogene SRC, PIG61, PSCTK 1, PSCTK 2, PSCTK 3, Protein tyrosine kinase BMX, Protein tyrosine kinase fyn, Protein tyrosine kinase leukocyte, Proto oncogene tyrosine protein kinase fyn, Proto-oncogene Neu, Proto-oncogene Syn, Proto-oncogene c-ErbB-1, Proto-oncogene c-ErbB-2, Proto-oncogene c-Fyn, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, Proto-oncogene-like protein c-ErbB-4, Protooncogene SRC, Protooncogene SRC Rous sarcoma, Receptor protein tyrosine kinase erbB 4 precursor, Receptor tyrosine protein kinase erbB 4, Receptor tyrosine-protein kinase ErbB-1, Receptor tyrosine-protein kinase erbB-2, SA7, SRC Oncogene, SRC proto oncogene non receptor tyrosine kinase, SRC_HUMAN, SYN, Species antigen 7, Src yes related novel gene, Src-like kinase, Src/yes related novel, TKR1, Tyrosine kinase B lymphocyte specific, Tyrosine kinase p59fyn T, Tyrosine kinase p59fyn(T), Tyrosine kinase pp60c src, Tyrosine kinase-type cell surface receptor HER2, Tyrosine kinase-type cell surface receptor HER3, Tyrosine kinase-type cell surface receptor HER4, Tyrosine protein kinase, Tyrosine protein kinase SRC 1, Tyrosine-protein kinase BLK, Tyrosine-protein kinase BTK, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase JAK3, Urogastrone, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog), V erb b2 avian erythroblastic leukemia viral oncogene homolog 3, V erb b2 avian erythroblastic leukemia viral oncoprotein 2, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian), V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4, VERBB2, Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived-oncogene homolog, Verba avian erythroblastic leukemia viral oncogene homolog like 4, Wa5, XLA, c erbB 3, dominant-negative kinase-deficient Brutons tyrosine kinase, erb-b2 receptor tyrosine kinase 1, erbB3 S, human epidermal growth factor receptor 4, mENA, oncogene ERBB3, p180 ErbB3, p180erbB4, p185erbB2, p45 sErbB3, p55-BLK, p59-Fyn, p60-Src, p60c-src, p85 sErbB3, pp60c-src, receptor tyrosine protein kinase ERB3 [precursor], s80HER4, truncated Bruton agammaglobulinemia tyrosine kinase, tyrosine-protein kinase BTK isoform (lacking exon 14, v erb a avian erythroblastic leukemia viral oncogene homolog like 4, v erb a erythroblastic leukemia viral oncogene homolog 4, v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog, v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), v-erb-b Avian erythroblastic leukemia viral oncogen homolog, wa2