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AB145146

PD 174265, EGFR tyrosine kinase inhibitor

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MW 371.24 g/mol, Purity >98%. Potent, selective, reversible EGFR tyrosine kinase inhibitor (IC50 = 0.45 nM). Antitumor agent. Cell permeable. Active in vivo and in vitro.

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Chemical Structure - PD 174265, EGFR tyrosine kinase inhibitor (AB145146)
  • Chemical Structure

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Chemical Structure - PD 174265, EGFR tyrosine kinase inhibitor (AB145146)

2D chemical structure image of ab145146, PD 174265, EGFR tyrosine kinase inhibitor

Key facts

CAS number

216163-53-0

Purity

>98%

Form

Solid

form

Molecular weight

371.24 g/mol

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>5</sub>BrN<sub>4</sub>O

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biological description

Potent, selective, reversible EGFR tyrosine kinase inhibitor (IC50 = 0.45 nM). Antitumor agent. Cell permeable. Active in vivo and in vitro.

See similar compounds

Canonical smiles

CCC(=O)NC1CCC2C(C1)C(NCN2)NC1CCCC(C1)BR

InChi

InChI=1S/C17H15BrN4O/c1-2-16(23)21-11-7-8-14-12(9-11)17(20-10-19-14)22-15-6-4-3-5-13(15)18/h3-10H,2H2,1H3,(H,21,23)(H,19,20,22)

InChiKey

FBZKDEWSVNSNMS-UHFFFAOYSA-N

IUPAC Name

N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]propanamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Biochemicals

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